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| 1 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 2 | Oxidation of lipid and protein in horse mackerel ( Trachurus trachurus ) mince and washed minces during processing and storage显示文摘 | Sylvie Eymard Caroline P. Baron Charlotte Jacobsen | 2008 | Food Chemistry2008，，1： | 3 |
| 3 | Oxidation of lipid and protein inhorse mackerel (trachurus trachurus) mince and washed minces during processing and storage 显示文摘 | EYMARD S BARON CP JACOBSEN C | 2009 | Food Chemistry2009，114，1： | 1 |
| 4 | Modeling anaerobic bioreactor landfills in methanogenic phase: long term and short term behaviors显示文摘 | GHOLAMIFARD S EYMARD R DUQUENNOI C | 2008 | Water Research2008，42，1011： | 1 |
| 5 | Randomized phase Ⅱ study of docetaxel plus estramustine and single-agent docetaxel in patients with metastatic hormone-refractory prostate cancer显示文摘 | Eymard JC Priou F Zannetti A | 2007 | Ann Oncol2007，18，6： | 1 |
| 6 | Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip 显示文摘 | THIRLWELL C EYMARD M FEBER A | 2010 | Methods2010，52，3： | 1 |
| 7 | Chronic progressive external ophthalmoplegia with ragged-red fibers: clinical, morphological and genetic investigations in 43 patients 显示文摘 | Laforet P Lombes A Eymard B | 1995 | Neuromuscul Disord1995，5，： | 1 |
| 8 | Diagnostic and clinical classification of autoimmune myasthenia gravis显示文摘 | Berrih-Aknin S Frenkian-Cuvelier M Eymard B | 2014 | J Autoimmun2014，，4849： | 1 |
| 9 | Isokinetic muscle testing for weak patients suffering from neuromuscular disorders: a reliability study显示文摘 | Tiffreau V Ledoux I Eymard B | 2007 | Neuromuscul Disord2007，17，7： | 1 |
| 10 | Anti-titin antibodies in myasthenia gravis:tight association with thymoma and heterogeneity of nonthymoma patients显示文摘 | Yamamoto A M Gajdos P Eymard B | 2001 | Arch Neurol2001，58，： | 1 |
| 11 | Cardiac involvement in genetically confirmed facioscapulohumeral muscular dystrophy显示文摘 | Laforet P de Toma C Eymard B | 1998 | Neurology1998，51，： | 1 |
| 12 | Microwave Land Emissivity Calculations Using AMSU Measurements 显示文摘 | Karbou F Prigent C Eymard L | 2005 | IEEE Trans Geosci Remote Sens2005，43，5： | 1 |
| 13 | Anti-Titin Antibodies in Myasthenia Gravis Tight association with thymoma and heterogeneity of nonthymoma patients显示文摘 | Yamamoto AM Gajdos P Eymard B | 2001 | Arch Neuro2001，58，6： | 1 |
| 14 | Paramyotonia congenita:genotype to phenotype correlations in two families and report of a new mutation in the sodium channel gene显示文摘 | Plassart E Eymard B Maurs L | 1996 | J Neurol Sci1996，142，： | 1 |
| 15 | Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study显示文摘 | Fabiano P. Saggioro Luciano Neder Jo?o Norberto Stávale Aline Nazareth P. Paix?o-Becker Suzana M.F. Malheiros Fernando A. Soares José Eymard H. Pittella Caio César M.S. Matias Benedicto O. Colli Carlos Gilberto Carlotti Marcello Franco | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 16 | Numerical Computation of Temperature Distribution in a Wellbore While Drilling 显示文摘 | Eymard R | | SPE0，，： | 1 |
| 17 | Osteoarthritis, inflammation and obesity显示文摘 | Berenbaum F Eymard F Houard X | 2013 | Curr Opin Rheumatol2013，25，1： | 1 |
| 18 | CREDIT CONSTRAINTS AND THE CYCLICALITY OF R&D INVESTMENT: EVIDENCE FROM FRANCE显示文摘 | Philippe Aghion Philippe Askenazy Nicolas Berman Gilbert Cette Laurent Eymard | 2012 | Journal of the European Economic Association2012，，5： | 1 |
| 19 | Aggregate sizes and stability in cultivated south dakota prairie ustolls and usterts显示文摘 | EYMARD A SCHUMACHER T E LINDSTROM M J | 2004 | Soil Sci Soc Am J2004，68，： | 1 |
| 20 | Metronomic oral cy- clophosphamide prednisolone chemotherapy is an effective treat- ment for metastatic hormone-refractory prostate cancer after doc- etaxel failure显示文摘 | Ladoire S Eymard J C Zanetta S | 2010 | Anticancer Res2010，30，10： | 1 |
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