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| 1 | Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion显示文摘Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during penetration.This ensures that the cargo is released at the predetermined place and time.Therefore,the ability of MN patches to sufficiently pierce the skin is a crucial requirement.In the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared.This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice.Factors that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research. | Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly | 2021 | Nano-Micro Letters2021，13，6： | 5 |
| 2 | Parasagiattal meningomas: follow-up review显示文摘 | Colli BO Carlotti CG Jr Assirati JA Jr | 2013 | Surg Neurol2013，66，3： | 1 |
| 3 | The new ICP minimallyinvasive method shows that the Monro-Kellie doctrine is not valid显示文摘 | Mascarenhas S Vilela GH Carlotti C | 2012 | Acta Neurochir Suppl2012，114，： | 1 |
| 4 | Vitamin A and vitamin A palmitate stability over time and under UVA and UVB radiation 显示文摘 | Carlotti ME Rossatto V Gallarate M | 2002 | Int J Pharm2002，240，12： | 1 |
| 5 | Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome显示文摘 | Maruani A Machet MC Carlotti A | 2008 | Am J Clin Pathol2008，130，3： | 1 |
| 6 | Glucocorticoid receptors,in vitro steroid sensitivity,and cytokine secretion in idiopathic nephrotic syndrome显示文摘 | Carlotti AP Franco PB Eliasl L | | 0，，02： | 1 |
| 7 | Preparation of griseofulvin nanoparticles from water-dilutable microemulsions显示文摘 | Trotta M Gallarate M Carlotti M E | 2003 | Int J Pharm2003，254，2： | 1 |
| 8 | Ras controls tumor necrosis factor receptor-associated factor ( TRAF ) 6-dependent induction of nuclear factor-kappa B, selective regulation through receptor signaling components 显示文摘 | Caunt CJ Kiss-Toth E Carlotti F | 2001 | J Biol Chem2001，276，9： | 1 |
| 9 | Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study显示文摘 | Fabiano P. Saggioro Luciano Neder Jo?o Norberto Stávale Aline Nazareth P. Paix?o-Becker Suzana M.F. Malheiros Fernando A. Soares José Eymard H. Pittella Caio César M.S. Matias Benedicto O. Colli Carlos Gilberto Carlotti Marcello Franco | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 10 | Management of keratosseborrhoeic disorders显示文摘 | Carlotti D N Bensignor E | 2002 | Eur J Comp Anita Praet2002，12，： | 1 |
| 11 | A method to estimate urinary electrolyte excretion in patients at risk for developing cerebral salt wasting显示文摘 | Carlotti AP Bohn D Rutka JT | 2001 | Neurosurg2001，95，3： | 1 |
| 12 | Partial sequencing of the cytochrcme oxydase-b subunit gene I: A tool for the identification of European species of blow flies for postmortem interval estimation 显示文摘 | Vincent S Vian JM Carlotti MP | 2000 | J Forensic Sci2000，45，： | 1 |
| 13 | Surgicat management of axis'traumatic spondylolisthesis(Hangman's fracture)显示文摘 | Colli BO Carlotti CG Jr | 2004 | Arq Neuropsiquiatr2004，62，3： | 1 |
| 14 | Parasagiattal meningomas:follow-up review 显示文摘 | Colli BO Carlotti CG Jr Assirati JA Jr | 2006 | Surg Neurol2006，66，3： | 1 |
| 15 | Preparation of griseofulvin nanoparticles from water-dilutable microemulsions显示文摘 | TROTTA M GALLARATE M CARLOTTI ME | 2003 | Int J Pharm2003，254，2： | 1 |
| 16 | Positively changed microemulsions for topical application 显示文摘 | Peira E Carlotti M E Trotta C | 2008 | Int J Pharm2008，346，12： | 1 |
| 17 | Making brand portfolios work显示文摘 | CARLOTTI S J COE M E PERREY J | 2004 | The McKinsey Quarterly2004，40，4： | 1 |
| 18 | Complexes of tetracyclines with divalent metal cations investigated by stationary and femtosecond- pulsed techniques 显示文摘 | CARLOTTI B CESARETTI A ELISEI F | 2012 | Physical Chemistry Chemical Physics2012，14，2： | 1 |
| 19 | Therapy, control and prevention of flea allergy dermatitis in dogs and cats显示文摘 | Carlotti D N Jacobs D E | 2002 | Vet Dermatol2002，11，： | 1 |
| 20 | Surgical management of axis' traumatic spondylolisthesis (Hangman' s fracture) 显示文摘 | Boullosa JL Colli BO Carlotti CG Jr | 2004 | Arq Neuropsiquiatr2004，62，： | 1 |
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