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| 1 | 红景天对阿尔茨海默病APP-C100转基因小鼠的影响显示文摘目的 探讨红景天对 AD转基因小鼠行为的影响和抗氧化应激反应的神经保护作用。方法 用 APP- C1 0 0转基因小鼠和健康(NTg)鼠模型来观察单剂红景天 8w抗氧化效果。Open field活动用来评估转基因鼠和健康鼠的移动、探索能力及焦虑状态。 Western印迹法定量分析转基因鼠血清及大脑 Cn/ Zn SOD1、APP及 Aβ蛋白含量。免疫组织化学法观察转基因鼠大脑皮层和海马的病理改变。结果 与 NTg鼠比较 ,转基因鼠通过格子次数 (grid cross)和排泄物 (粪尿 )均显著增加 (P<0 .0 5)。通过 Western印迹法及密度定量测定 ,红景天治疗组的转基因鼠 Cn/ ZnSOD1蛋白含量在血清及大脑中较对照组明显减少 (P<0 .0 5)。大脑 APP、βCTF及 Aβ蛋白含量无变化 ,免疫组化在大脑皮层和海马未见 Aβ沉积。结论 红景天可通过减少 SOD1氧化蛋白的含量 。 | 朱爱琴 Qiao-xin Li 张鑫生 滕长青 楮以德 Colin L Masters Amee George Tian Cardamong Genevieve Evin | 2004 | 中国老年学杂志2004，24，6： | 8 |
| 2 | Clinicopathological features and outcomes of patients with gastric cancer:A single-center experience显示文摘AIM:To evaluate the location,histopathology,stages,and treatment of gastric cancer and to conduct survival analysis on prognostic factors.METHODS:Patients diagnosed with of stomach cancer in our clinic between 2000 and 2011,with follow-up or a treatment decision,were evaluated retrospectively.They were followed up by no treatment,adjuvant therapy,or metastatic therapy.We excluded from the study any patients whose laboratory records lacked the operating parameters.The type of surgery in patients diagnosed with gastric cancer was total gastrectomy,subtotal gastrectomy or palliative surgery.Patients with indications for adjuvant treatment were treated with adjuvant and/or radio-chemotherapy.Prognostic evaluation was made based on the parameters of the patient,tumor and treatment.RESULTS:In this study,outpatient clinic records of patients with gastric cancer diagnosis were analyzed retrospectively.A total of 796 patients were evaluated(552male,244 female).The median age was 58 years(22-90 years).The median follow-up period was 12 mo(1-276 mo),and median survival time was 12 mo(11.5-12.4 mo).Increased T stage and N stage resulted in a decrease in survival.Other prognostic factors related to the disease were positive surgical margins,lymphovascular invasion,perineural invasion,cardio-esophageal settlement,and the levels of tumor markers in metastatic disease.No prognostic significance of the patient's age,sex or tumor histopathology was detected.CONCLUSION:The prognostic factors identified in all groups and the proposed treatments according to stage should be applied,and innovations in the new targeted therapies should be followed. | Fatih Selcukbiricik Evin Buyukunal Deniz Tural Mustafa Ozguroglu Fuat Demirelli Suheyla Serdengecti | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 3 | Platelets and Alzheimer's disease:Potential of APP as a biomarker显示文摘Platelets are the first peripheral source of amyloid precursor protein(APP). They possess the proteolytic machinery to produce Aβ and fragments similar to those produced in neurons, and thus offer an ex-vivo model to study APP processing and changes associated with Alzheimer's disease(AD). Platelet process APP mostly through the α-secretase pathway to release soluble APP(s APP). They produce small amounts of Aβ, predominantly Aβ40 over Aβ42. s APP and Aβ are stored inα-granules and are released upon platelet activation by thrombin and collagen, and agents inducing platelet degranulation. A small proportion of full-length APP is present at the platelet surface and this increases by 3-fold upon platelet activation. Immunoblotting of platelet lysates detects APP as isoforms of 130 kD a and106-110 kD a. The ratio of these of APP isoforms is significantly lower in patients with AD and mild cognitive impairment(MCI) than in healthy controls. This ratio follows a decrease that parallels cognitive decline andcan predict conversion from MCI to AD. Alterations in the levels of α-secretase ADAM10 and in the enzymatic activities of α- and β-secretase observed in platelets of patients with AD are consistent with increased processing through the amyloidogenic pathway. β-APP cleaving enzyme activity is increased by 24% in platelet membranes of patients with MCI and by 17% in those with AD. Reports of changes in platelet APP expression with MCI and AD have been promising so far and merit further investigation as the search for blood biomarkers in AD, in particular at the prodromal stage, remains a priority and a challenge. | Geneviève Evin Qiao-Xin Li | 2012 | World Journal of Psychiatry2012，2，6： | 4 |
| 4 | Geochemical constraints on the origin and tectonic setting of the serpentinized peridotites from the Paleoproterozoic Nyong series,Eseka area,SW Cameroon显示文摘Serpentinized rocks closely associated with Paleoproterozoic eclogitic metabasites were recently discovered at Eseka area in the northwestern edge of the Congo craton in southern Cameroon.Here,we present new field data,petrography,and first comprehensible wholerock geochemistry data and discuss the protolith and tectonic significance of these serpentinites in the region.The studied rock samples are characterized by pseudomorphic textures,including mesh microstructure formed by serpentine intergrowths with cores of olivine,bastites after pyroxene.Antigorite constitutes almost the whole bulk of the rocks and is associated(to the less amount)with tremolite,talc,spinel,and magnetite.Whole-rock chemistry of the Eseka serpentinites led to the distinction of two types.Type 1 has high MgO(>40 wt%)content and high Mg#values(88.80)whereas Type 2 serpentinite samples display relatively low MgO concentration and Mg#values(<40 and 82.88 wt%,respectively).Both types have low Al/Si and high Mg/Si ratios than the primitive mantle,reflecting a refractory abyssal mantle peridotite protolith.Partial melting modeling indicates that these rocks were derived from melting of spinel peridotite before serpentinization.Bulk rock high-Ti content is similar to the values of subducted serpentinites(>50 ppm).This similarity,associated with the high Cr contents,spinel-peridotite protolith compositions and Mg/Si and Al/Si ratios imply that the studied serpentinites were formed in a subductionrelated environment.The U-shaped chondrite normalizedREE patterns of serpentinized peridotites,coupled with similar enrichments in LREE and HFSE,suggest the refertilized nature due to melt/rock interaction prior to serpentinization.Based on the results,we suggest that the Eseka serpentinized peridotites are mantle residues that suffered a high degree of partial melting in a subductionrelated environment,especially in Supra Subduction Zone setting.These new findings suggest that the Nyong series in Cameroon represents an uncontested Paleoproterozoic suture zone between the Congo craton and the Sao Francisco craton in Brazil. | Philomene Nga Essomba Tsoungui Sylvestre Ganno Evine Laure Tanko Njiosseu Jean Lavenir Ndema Mbongue Brice Kamguia Woguia Landry Soh Tamehe Jonas Didero Takodjou Wambo Jean Paul Nzenti | 2020 | Acta Geochimica2020，39，3： | 3 |
| 5 | Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices显示文摘 | Evin Gultepe Dattatri Nagesha Srinivas Sridhar Mansoor Amiji | 2009 | Advanced Drug Delivery Reviews2009，，3： | 2 |
| 6 | Myc oncogenes: the genimatic family 显示文摘 | evin MR George DB | 1996 | J Biochem1996，314，： | 1 |
| 7 | Medical morbidity and mortality in schizophrenia: guidalines for psychiatrists 显示文摘 | Goff DC Cather C Evins E | 2005 | Clitt Psychiatry2005，66，： | 1 |
| 8 | A dynamic distribution model for combat logistics computers显示文摘 | evin R Gue | 2003 | Operations Research2003，，30： | 1 |
| 9 | The role of arbuscular mycorrhizal fungi and glomalin in soil aggregation: comparing effects of five plant species显示文摘 | Rillig MC Wright SF Eviner VT | 2002 | Plant and Soil2002，238，2： | 1 |
| 10 | Seasonal variations in plant species effects on soil N and P dynamics显示文摘 | EVINER V T CHAPIN F S VAUGHN C E | 2006 | Ecology2006，87，： | 1 |
| 11 | Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists显示文摘 | Goff D C Cather C Evins E | 2005 | J Clin Psychiatry2005，66，： | 1 |
| 12 | OXIDANT AND ANTIOXIDANT SYSTEMS IN NIDDM PATIENTS: INFLUENCE OF VITAMIN E SUPPLEMENTATION显示文摘 | Cahide G?kkus?u S?ükrü Palanduz Evin Ademo?lu S?ule Tamer | 2001 | Endocrine Research2001，，3： | 1 |
| 13 | Consequences of changing biodiversity 显示文摘 | CHAPIN F S ZAVALETA E S EVINER V T | 2000 | Nature2000，4，： | 1 |
| 14 | Understanding the long-term effects of speciesinvasions 显示文摘 | Strayer D L Eviner V T Jeschke J M | 2006 | Trends in Ecology & Evolution2006，21，11： | 1 |
| 15 | Experimental and clinical performance of porous tantalum in orthopedic surgery显示文摘 | Evine BR Sporer S Poggie RA | 2006 | Biomaterials2006，27，27： | 1 |
| 16 | Facilitating tacit knowledge exchange 显示文摘 | Evin C Desouza E | 2003 | Communications of the ACM2003，46，1： | 1 |
| 17 | Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease显示文摘 | Altan Onat Günay Can Ender ?rnek Servet Altay Murat Yüksel Evin Ademo?lu | 2013 | Clinical Rheumatology2013，，： | 1 |
| 18 | The role of arbuscular myeorrhizal fungi and glomalin in soil aggregation:Comparing effects of five plant species 显示文摘 | Rillig M C Wright S F Eviner V T | 2002 | Plant and Soil2002，238，2： | 1 |
| 19 | The Investigation of Contact Performance of Oxide Reinforced Copper Composite Via Mechanical Alloying显示文摘 | Omer Guler Ertan Evin | 2009 | Journal of Materials Processing Technology2009，209，： | 1 |
| 20 | Financial development and economic growth: views and agenda显示文摘 | I EVINE R | 1997 | Journal of Economic Literature1997，35，2： | 1 |
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