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| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Multiple forms of hydroxycinnamate:CoA ligase in etiolated pea seedling显示文摘 | RHODES M J C | 1977 | Phytochemistry1977，16，： | 1 |
| 3 | Thalassiolins A-C: new marine-derived inhibitors of HIV eDNA integrase显示文摘 | Rowley D C Hansen M S T Rhodes D | 2002 | Bioorg Med Chen2002，10，： | 1 |
| 4 | Animal and temporal effects on ovarian follicular dynamics in Brahman heifers显示文摘 | Rhodes J M de Ath G Entwisfle K W | 1995 | Anita Reprod Sci1995，38，： | 1 |
| 5 | Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contraction 显示文摘 | BATTERBURY M TEBBS CA RHODES JM | 2002 | Experimental Eye Research2002，4，3： | 1 |
| 6 | Content - Centered Collaboration Spaces in the Cloud 显示文摘 | ERICKSON J S SPENCE S RHODES M | 2009 | IEEE Internet Computing2009，13，5： | 1 |
| 7 | Post-failure behaviour of box section beams under pure bending (an experimental study) 显示文摘 | KOTELKO M LIM T H RHODES J | 2000 | Thin-walled Structures2000，38，2： | 1 |
| 8 | Laparoscopic exploration of the common bile duct: lessons learnes from 129 consecutive cases显示文摘 | Rhodes M Nathanson L Orourk N | 1995 | Brit J Surg1995，82，6： | 1 |
| 9 | High levels of endemicity of 3-chlorobenzoate-degrating soil bacteria显示文摘 | FULTHORPE R R RHODES A N TIEDJE J M | 1998 | Applied and Environmental Microbiology1998，64，5： | 1 |
| 10 | Free radicals,metals and antioxidants in oxidative stress-induced cancer显示文摘 | Valko M Rhodes C J Moncol J | 2006 | Chem Biol Interact2006，160，1： | 1 |
| 11 | Towards T-tube free laparoscopic bile duct exploration: methodologic evolution during 300 consecutive procedures 显示文摘 | Martin IJ Bailey IS Rhodes M | 1998 | Ann Surg1998，228，1： | 1 |
| 12 | Seasonal and habitat dependence of fleas parasitic on small mammals in Tanzania 显示文摘 | Anne L Herwig L Rhodes M | 2009 | Integrative Zool2009，4，5： | 1 |
| 13 | Impact of air staging on the fate of NO and N2O in a circulating fluidized-bed combustor 显示文摘 | Wang X S Gibbs B M Rhodes M J | 1994 | Combustion and Flame1994，99，34： | 1 |
| 14 | Headgroup effect on silane structures at buried polymer/silane and polymer/polymer interfaces and their relations to adhesion显示文摘 | Zhang C Shephard N E Rhodes S M | 2012 | Langmuir2012，28，14： | 1 |
| 15 | Analysis of the major flavonol glycoside present in four varieties of onion and changes in composition resulting from autolysis 显示文摘 | Price K R Rhodes M J C | 1997 | J Sci Food Ag- rlc1997，74，： | 1 |
| 16 | Study of Geldart's Group A behaviour using the discrete element method simulation 显示文摘 | Pandit J K Wang X S Rhodes M J | 2005 | Powder Technology2005，160，1： | 1 |
| 17 | Properties of friction-stir-welded 7075 T651 aluminum 显示文摘 | MAHONEY M W RHODES C G FLINTOFF J G SPURLING R A BINGEL W H | 1998 | Metallurgical and Materials Transactions A1998，29，： | 1 |
| 18 | Internal spatial modes in glass microring resonators显示文摘 | Goldberg B B Unlu M S Chu S T Little B | 2000 | IEEE Journal on Selected Topics in Quantum Electronics2000，，： | 1 |
| 19 | Towards T-tube free laparoscopic bile dust exploration: a methodologic evolution during 300 consecutive procedures显示文摘 | MARTIN IJ PAILEY IS RHODES M | 1998 | Ann Surg1998，228，： | 1 |
| 20 | Effect of friction stir welding on microstructure of 7075 aluminum 显示文摘 | Rhodes C G Mahoney M W Bingel W H | 1997 | Seripta Materialia1997，36，1： | 1 |
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