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| 1 | Protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning显示文摘AIM: To explore if ischemic preconditioning(IPC) can enhance the survival of retinal ganglion cells(RGCs) after optic nerve axotomy. METHODS: Twenty-four hours prior to retinal ischemia 60 min or axotomy, IPC was applied for ten minutes in groups of(n=72) animals. The survival of RGCs, the cellular expression of heat shock protein 27(HSP27) and heat shock protein 70(HSP70) and the numbers of retinal microglia in the different groups were quantified at 7 and 14 d post-injury. The cellular expression of HSP27 and HSP70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IPC. RESULTS: Ten minutes of IPC promoted RGC survival in both the optic nerve injury(IPC-ONT) and the retinal ischemia 60min(IPC-IR60) groups, examined at 7d and 14 d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IPC on the rescue of RGCs. The number of HSP27-positive RGCs was significantly higher in the IPC-ONT group than in the sham IPC-ONT group, although the percentage of HSP27-positive RGCs did not significantly differ between groups. For the IPC-IR60 group, neither the number nor the percentage of the HSP27-positive RGCs differed significantly between the IPC and the sham-operated groups. The number of HSP70-positive RGCs was significantly higher for both the IPC-ONT and the IPC-IR60 experimental groups, but the percentages did not differ. CONCLUSION: The induction of IPC enhances the survival of RGCs against both axotomy and retinal ischemia. | Xia Liu Jiu-Ping Liang Ou Sha Song-Juan Wang Heng-Guo Li Eric Y.P.Cho | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 2 |
| 2 | Low moisture permeation measurement through polymer substrates for organic light emitting devices 显示文摘 | Kumar R S Auch Mark Ou Eric | 2002 | Thin Solid Films2002，417，12： | 1 |
| 3 | In vitro human digestion models for food applications显示文摘 | Sun Jin Hur Beong Ou Lim Eric A. Decker D. Julian McClements | 2010 | Food Chemistry2010，，1： | 1 |
| 4 | In vitro human digestion models for food applications显示文摘 | Sun Jin Hur Beong Ou Lim Eric A Decker | 2011 | Food Chemistry2011，121，1： | 1 |
| 5 | Mechanistic aspects of the interaction between selenium and arsenic显示文摘 | Zeng H Eric OU Gerald FC | 2005 | J Inorg Biochem2005，99，： | 1 |
| 6 | Factors Associated With Positive Findings From Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding显示文摘 | Neal C. Shahidi George Ou Sigrid Svarta Joanna K. Law Ricky Kwok Jessica Tong Eric C. Lam Robert Enns | 2012 | Clinical Gastroenterology and Hepatology2012，，12： | 1 |
| 7 | Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy:Canadian tertiary center experience显示文摘AIM To develop a prediction model aimed at identifying patients that may require higher than usual sedation doses during colonoscopy.METHODS A retrospective chart review on 5000 patients who underwent an outpatient colonoscopy at St.Paul's Hospital from 2009 to 2010 was conducted in order to develop a model for identifying patients who will require increased doses of sedatives.Potential predictor variables including age,gender,endoscopy indication,high sedation requirements during previous endoscopies,difficulty of the procedure,bowel preparation quality,interventions,findings as well as current use of benzodiazepines,opioids and alcohol were analyzed.The outcome of study was the use ofhigh dose of sedation agents for the procedure.In particular,the high dose of sedation was defined as fentanyl greater than 50 mcg and midazolam greater than 3 mg.RESULTS Analysis of 5282 patients(mean age 57 ± 12,49% female) was performed.Most common indication for the procedure was screening colonoscopy(57%).Almost half of our patients received doses exceeding Fentanyl 50 mcg and Midazolam 3 mg.Logistic regression models identified the following variables associated with high sedation:Younger age(OR=0.95 95%CI:0.94-0.95;P < 0.0001);abdominal pain(OR=1.45,95%CI:1.08-1.96);P=0.01) and Inflammatory Bowel Disease(OR=1.45,95%CI:1.04-2.03;P=0.02) as indications for the procedure;difficult procedure as defined by gastroenterologist(OR=1.73,95%CI:1.48-2.03;P < 0.0001);past history of abdominal surgery(OR=1.33,95%CI:1.17-1.52;P <0.0001) and previous colonoscopy(OR=1.39,95%CI:1.21-1.60;P=0.0001) and alcohol use(OR=1.26,95%CI:1.03-1.54;P=0.02).Age and gender adjusted analysis yielded inflammatory bowel disease as an indication(OR=3.17,95%CI:1.58-6.37;P=0.002);difficult procedure as defined by an endoscopist(OR=5.13 95%CI:2.97-8.85;P=0.0001) and current use of opioids,benzodiazepines or antidepressants(OR=2.88,95%CI:1.74-4.77;P=0.001) having the highest predictive value of high sedation requirements.Our prediction model using the following pre-procedural variables including age,indication for the procedure,medication/substance use,previous surgeries yielded an area under the curve of 0.76 for Fentanyl ≥ 100 mcg and Midazolam ≥ 3 mg.CONCLUSION Pre-procedural planning is the key in conducting successful,efficient colonoscopy.Logistic regression analysis of 5000 patients who underwent out-patient colonoscopy revealed the following factors associated with increased sedation requirement:Younger age,female gender,difficult endoscopy,specific indications as well as cardiopulmonary complications and current use of opioids/benzodiazepines.Age and gender adjusted analysis yielded similar results.These patients are more likely to need a longer recovery periods post-endoscopy,which could result in additional time and personnel requirements.The final predictive model has good predictive ability for Fentanyl ≥ 100 mcg and Midazolam ≥ 3 mg and fair predictive ability for Fentanyl ≥ 50 mcg and Midazolam ≥ 2 mg.The external validity of this model is planned to be tested in another center. | Alexandra Shingina George Ou Oliver Takach Sigrid Svarta Ricky Kwok Jessica Tong Kieran Donaldson Eric Lam Robert Enns | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 1 |
| 8 | Body mass index as a determinant of carotid intima-media thickness in Nigerian adults with primary hypertension显示文摘 | Eric OU Atinuke MA Abiodun OA | 2014 | Ann Afr Med2014，13，4： | 1 |
| 9 | DNA Methylation, Cancer susceptibility, and nutrient interactions 显示文摘 | Cindy DD Eric OU | 2004 | Exp Biol Med2004，229，： | 1 |
| 10 | Mechanistic aspects of the interaction between selenium and arsenic显示文摘 | Zeng H Eric OU Gerald FC Jr | 2005 | J Inorg Biochem2005，99，： | 1 |
| 11 | 大众绅士 优雅朗仕——LANSE朗仕P-588扬声器评析显示文摘LANAE朗仕P-588为三路四单元全平衡式设计,1.3m高的箱体分三个独立声腔,以最大限度地减少驻波及串扰。箱体前障板和背板用15mm厚度的高密度纤维板(HDF)制造,这种合成木料具有高硬度及理想的阻尼特性,在前障板上再镶入一15mm PU烤漆面板。 | Eric Ou | 2002 | 家庭影院技术2002，，6： | 0 |
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