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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | Endoscopic pancreatic sphincterotomy:indications,outcome,and a safe stentless technique显示文摘Endoscopicpancreaticsphincterotomy:indications,outcome,andasafestentlesstechniquericElton,MD,DouglasA.Howel,MD,WilisG.Parsons... | Eric Elton, MD, Douglas A. Howell, MD, Willis G. Parsons, MD, Tahir Qaseem, MD, Brian L. Hanson, MDPortland, MaineDivision of Gastroenterology, Maine Medical Center, Portland, Maine | 1998 | World Journal of Gastroenterology1998，4，3： | 16 |
| 3 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 4 | Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy显示文摘 | Gauri R. Varadhachary MD Eric P. Tamm MD James L. Abbruzzese MD Henry Q. Xiong MD Christopher H. Crane MD Huamin Wang MD Jeffrey E. Lee MD Peter W. T. Pisters MD Douglas B. Evans MD Robert A. Wolff MD | 2006 | Annals of Surgical Oncology2006，，8： | 4 |
| 5 | Surgical Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus显示文摘 | Jie Shi MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Nan Li MD Wei-Xing Guo MD Jie Xue MD Wan Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD | 2010 | Annals of Surgical Oncology2010，，8： | 2 |
| 6 | A Comparative Study of Antiviral Therapy After Resection of Hepatocellular Carcinoma in the Immune-Active Phase of Hepatitis B Virus Infection显示文摘 | Nan Li MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Jie Shi MD Wei-Xing Guo MD Jie Xue MD Bing Huang MD Wan-Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD | 2010 | Annals of Surgical Oncology2010，，1： | 2 |
| 7 | Spleen-preserving Distal Pancreatectomy with Excision of Splenic Artery and Vein: A Case-matched Comparison with Conventional Distal Pancreatectomy with Splenectomy显示文摘 | Nicolas Carrère MD Skander Abid MD Charles Henri Julio MD Eric Bloom MD Bernard Pradère MD | 2007 | World Journal of Surgery2007，，2： | 2 |
| 8 | A randomized trial of late reperfusion therapy for acute myocardial infarction显示文摘 | Eric J Topol MD Robert M | 1992 | Circulation1992，85，6： | 1 |
| 9 | Construction and expression in tumor cells of a recombinant vaccinia virus encoding human interleukin-1β显示文摘 | Gary R. Peplinski MD Kangla Tsung PhD Eric D. Whitman MD Jennifer B. Meko MD Dr. Jeffrey A. Norton MD | 1995 | Annals of Surgical Oncology1995，，2： | 1 |
| 10 | Comparison of Lateral Release Versus Lateral Release With Medial Soft-Tissue Realignment for the Treatment of Recurrent Patellar Instability:A Systematic Re-view显示文摘 | Eric T Ricchetti MD Samir Mehta MD | | 0，，： | 1 |
| 11 | Paclitaxel (Taxol) 显示文摘 | Eric K Rowinsky MD Ross C | 1995 | N Engl J Med1995，332，15： | 1 |
| 12 | Spirometry testing Standards in Spinal Cord Injury显示文摘 | Kelley A Eric BS Garshick MD | 2003 | Chest2003，123，： | 1 |
| 13 | Small-dose bupivacaine-sufentanil prevents cardiac output modifications after spinal anesthesia显示文摘 | Karim Asehnoune MD Eric Larousse MD Jean Marc Tadié MD | 2005 | Anesth Analg2005，101，5： | 1 |
| 14 | Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin for Peritoneal Carcinomatosis Arising from Appendix: Preliminary Results of a Survival Analysis显示文摘 | Eric Marcotte MD Lucas Sideris MD FRCSC Pierre Drolet MD FRCPC Andrew Mitchell MD Suzanne Frenette BPharm MSc BCOP Guy Leblanc MD FRCSC Yves E. Leclerc MD FRCSC FACS Pierre Dubé MD MSc FRCSC FACS | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 15 | Spleen-preserving Distal Pancreatectomy with Excision of Splenic Artery and Vein: A Case-matched Comparison with Conventional Distal Pancreatectomy with Splenectomy显示文摘 | Nicolas Carrère MD Skander Abid MD Charles Henri Julio MD Eric Bloom MD Bernard Pradère MD | 2007 | World Journal of Surgery2007，，2： | 1 |
| 16 | Montelukast for respiratory syncytial virus bronchiolitis显示文摘 | Stanley J Szefler MD Eric AF | 2003 | Respir Crit care Med2003，167，3： | 1 |
| 17 | Montelukast for respiratory syncytial virus bronchiolitis显示文摘 | Stanley J Szefler MD Eric AF | 2003 | Respir Crit Care Med2003，167，3： | 1 |
| 18 | Intravenous cyclosporine in attacks of ulcerative colitis显示文摘 | Dr. Franck Carbonnel MD Arnaud Boruchowicz MD Bernard Duclos MD Jean Claude Soulé MD Eric Lerebours MD Marc Lémann MD Jean Bela?che MD Jean Frédéric Colombel MD Jacques Cosnes MD Jean Pierre Gendre MD | 1996 | Digestive Diseases and Sciences1996，，12： | 1 |
| 19 | Remodeling of the temporomandibular joint following mandibular distraction osteogenesis in the transverse dimension 显示文摘 | Stelnicki MD Susan U | 2001 | Plast Reconstr Surg2001，107，： | 1 |
| 20 | Practical guidelines for initiation of beat-adrenergic blockade in patients with chronic heart failure显示文摘 | Eric J Eichhorn MD Michael R | 1997 | Am J Cardiol1997，70，5： | 1 |
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