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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | ACCF/SCAI/SVMB/SIR/ASITN 2007年颈动脉支架置入术临床专家共识文件——美国心脏病学会基金会特别工作组关于临床专家共识文件的报告(ACCF/SCAI/SVMB/SIR/ASITN颈动脉支架置入术临床专家共识文件委员会):与美国介入与治疗神经放射学学会、心血管造影和介入治疗学会、血管医学和生物学学会、介入放射学学会联合发布显示文摘序言
本文件在美国心血管造影和介入治疗学会(Society for Cardiovascular Angiography and Interventions,SCAI)、血管医学和生物学学会(Society for Vascular Medicine and Biology,SVMB)、介入放射学学会(Society of Interventional Radiology,SIR)、美国介入与治疗神经放射学学会(American Society of Interventional & Therapeutic Neuroradiology,ASITN)共同倡导下, | Bates ER Babb JD Casey DE Jr Cates CU Duckwiler GR Feldman TE Gray WA Ouriel K Peterson ED Rosenfield K Rundback JH Safian RD Sloan MA White CJ 刘慧慧(译) 吴延华(译) 靳勇(译) 曹勇军(译) 刘春风(译) | 2007 | 国际脑血管病杂志2007，15，5： | 52 |
| 3 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 4 | Is nasopharyngeal cancer really a “Cantonese cancer”?显示文摘Nasopharyngeal cancer(NPC) is endemic in Southern China,with Guandong province and Hong Kong reporting some of the highest incidences in the world.The journal Science has called it a 'Cantonese cancer'.We propose that in fact NPC is a cancer that originated in the Bai-Yue('proto-Tai-Kadai' or 'proto-Austronesian' or 'proto-Zhuang') peoples and was transmitted to the Han Chinese in southern China through intermarriage.However,the work by John Ho raised the profile of NPC,and because of the high incidence of NPC in Hong Kong and Guangzhou,NPC became known as a Cantonese cancer.We searched historical articles,articles cited in PubMed,Google,monographs,books and Internet articles relating to genetics of the peoples with high populations of NPC.The migration history of these various peoples was extensively researched,and where possible,their genetic fingerprint identified to corroborate with historical accounts.Genetic and anthropological evidence suggest there are a lot of similarities between the Bai-Yue and the aboriginal peoples of Borneo and Northeast India;between Inuit of Greenland,Austronesian Mayalo-Polynesians of Southeast Asia and Polynesians of Oceania,suggesting some common ancestry.Genetic studies also suggest the present Cantonese,Minnans and Hakkas are probably an admixture of northern Han and southern Bai-Yue.All these populations have a high incidence of NPC.Very early contact between southern Chinese and peoples of East Africa and Arabia can also account for the intermediate incidence of NPC in these regions. | Joseph Tien Seng Wee Tam Cam Ha Susan Li Er Loong Chao-Nan Qian | 2010 | Chinese Journal of Cancer2010，29，5： | 37 |
| 5 | siRNA therapeutics:a clinical reality显示文摘Since the revolutionary discovery of RNA interference(RNAi),a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)therapeutics.Despite its tremendous potential benefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of siRNA.Twenty years after the discovery of RNAi,siRNA therapeutics finally charts its way into clinics.As we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease treatments.Herein,we highlight the breakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical trials.Lastly,we present some challenges and multiple barriers that are yet to be fully overcome in siRNA therapeutics. | Phei Er Saw Er-Wei Song | 2020 | Science China(Life Sciences)2020，63，4： | 26 |
| 6 | Non-coding RNAs:the new central dogma of cancer biology显示文摘The central dogma of molecular biology states that the functions of RNA revolve around protein translation.Until the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed RNAs.Recent discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being'junk'transcriptional products to'yet to be elucidated'—and potentially monumentally important—RNAs.Most ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and fates.In major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ncRNAs.Herein,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics. | Phei Er Saw Xiaoding Xu Jianing Chen Er-Wei Song | 2021 | Science China(Life Sciences)2021，64，1： | 21 |
| 7 | Sliding Mode Controller Design for Position and Speed Control of Flight Simulator Servo System with Large Friction显示文摘Flight simulator is an important device and a typical high-performance position and speed servo system used in the hardware-in-the-loop simulation of flight control system. Friction is the main nonlinear resistance in the flight simulator servo system, especially in a low-speed state. Based on the description of dynamic and static models of a nonlinear Stribeck friction model, this paper puts forward sliding mode controller to overcome the friction, whose stability is proved. Simulation example indicates that the controller can guarantee a high robust performance and have a high precision of position tracking and speed tracking for a flight simulator servo system. | Liu Jinkun & Er LianjieAutomatic Control Department, Beijing University of Aeronautics and Astronautics, Beijing 100083, P. R. China | 2003 | Journal of Systems Engineering and Electronics2003，14，3： | 21 |
| 8 | Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia显示文摘 | Yue - Ping Yu Qiu - Qin Xu Qi Zhang Wei - Ping Zhang Li - Hui Zhang Er - Qing Wei | 2005 | 中国药理通讯2005，22，4： | 20 |
| 9 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 10 | Cirrhotic cardiomyopathy:A cardiologist's perspective显示文摘Cardiac dysfunction is frequently observed in patients with cirrhosis, and has long been linked to the direct toxic effect of alcohol. Cirrhotic cardiomyopathy(CCM) has recently been identified as an entity regardless of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation is a pathophysiological hallmark of the disease. The underlying mechanisms involved in pathogenesis of CCM are complex and involve various neurohumoral and cellular pathways, including the impaired β-receptor and calcium signaling, altered cardiomyocyte membrane physiology, elevated sympathetic nervous tone and increased activity of vasodilatory pathways predominantly through the actions of nitric oxide, carbon monoxide and endocannabinoids. The main clinical features of CCM include attenuated systolic contractility in response to physiologic or pharmacologic strain, diastolic dysfunction, electrical conductance abnormalities and chronotropic incompetence. Particularly the diastolic dysfunction with impaired ventricularrelaxation and ventricular filling is a prominent feature of CCM.The underlying mechanism of diastolic dysfunction in cirrhosis is likely due to the increased myocardial wall stiffness caused by myocardial hypertrophy,fibrosis and subendothelial edema,subsequently resulting in high filling pressures of the left ventricle and atrium.Currently,no specific treatment exists for CCM.The liver transplantation is the only established effective therapy for patients with end-stage liver disease and associated cardiac failure.Liver transplantation has been shown to reverse systolic and diastolic dysfunction and the prolonged QT interval after transplantation.Here,we review the pathophysiological basis and clinical features of cirrhotic cardiomyopathy,and discuss currently available limited therapeutic options. | Natig Gassanov Evren Caglayan Nasser Semmo Gero Massenkeil Fikret Er | 2014 | World Journal of Gastroenterology2014，20，42： | 18 |
| 11 | 聚乙烯磨损颗粒的大小对人工关节松动的影响显示文摘目的 探讨超高分子聚乙烯磨损颗粒 (UHMWPE)的大小对人工关节松动的影响。方法 从翻修髋关节术所获得组织中提取超高分子聚乙烯磨损颗粒 (平均直径 9.41、5 .96、0 .5 6、0 .3 3 μm ) ,将其与Ceridust 3 615 R○ 颗粒 (模型颗粒 ) (平均直径 14 .2 7、6.3 9、1.74、1.0 1、0 .5 4和 0 .2 8μm)分别刺激人单核 /巨噬细胞 ,并检测培养上清液中的骨溶解介质。 结果 随着UHMWPE颗粒直径的减少 ,其刺激单核 /巨噬细胞分泌白细胞介素 1β ,白细胞介素 6和细胞坏死因子α的作用明显增强 ,而Ceridust 3 615 R○ 颗粒的大小对单核 /巨噬细胞的刺激作用影响不明显。结论 单核 /巨噬细胞对UHMWPE磨损颗粒与Ceridust 3 615 R○ 颗粒的反应明显不同 ,运用模型颗粒研究人工关节松动的机制仍须谨慎。 | 丁悦 Bertram Barden 刘尚礼 黄东生 Franz Ler | 2004 | 中华实验外科杂志2004，21，3： | 17 |
| 12 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 13 | Triptolide Inhibits Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Human Colon Cancer and Leukemia Cells显示文摘Triptolide ( TP ),繁体中文药,被报导了在在几人的肿瘤 celllines.This 研究的肿瘤的活动调查的自体免疫的疾病和施加的反的治疗有效在人的结肠癌房间( SW114 )的 TP 的反肿瘤效果 andmyelocytic 白血病( K562 ),并且阐明可能的分子的机制 involved.SW114 和 K562cells 与 TP ( 0,5,10,20 ,或 50 ng/ml )的不同剂量被对待。房间生存能力被 3- 估计[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物(MTT ) 。结果证明 TP 以一种剂量依赖者方式禁止了两根肿瘤房间线的增长。为了推进,调查它的机制,产品前列腺素 E2 (PGE2 ) 和氮的氧化物(没有) 被连接酶的免疫吸着剂试金(ELISA ) 测量。我们的数据证明 TP 强烈禁止了生产没有并且有这些的 PGE2.Consistent 结果,表示可诱导合酶(i NOS ) 和 cyclooxygenase-2 (COX-2 ) 都不在 mRNA 水平和蛋白质表示水平两个都是起来调整的由即时 RT-PCR 并且西方的弄污出现。这些结果显示煽动性的因素 COX-2 和 i NOS 活动的抑制能涉及 TP 的 antitumormechanisms。 | Xiangmin TONG~# Shui’er ZHENG~# Jie JIN Lifen ZHU Yinjun LOU and Hangping YAO Institute of Hematologic Disease,Department of Hematology,First Affiliated Hospital,Medical School,Zhejiang University,Hangzhou 310003,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 12 |
| 14 | Meiofauna distributions at the oxygen minimum zone in Changjiang (Yangtze) River Estuary waters显示文摘A quantitative study on meiofauna was carried out along a transect throughout the Changjiang Estuary’s oxygen minimum zone (OMZ) in the East China Sea. There exist two distinct station groups in the OMZ: the fine-grained hypoxic area and the more fine-grained anoxic area. Meiofauna abundance ranged from (101.5±31.0) ind./cm2 (hypoxic area) to (369.9±123.9) ind./cm2 (anoxic area) along the transect. Free-living marine nematodes were the numerically dominant meiofauna at every station. The anoxic area differed significantly in meiofauna abundance and vertical distribution pattern from the hypoxic area. Within the anoxic area, nematodes abundance increased and amounted to over 90% of the total meiofauna; about 50% of nematodes were found in the 25 and 58 cm layers. At hypoxic stations, about over 85% were restricted to the top 2 cm. Benthic copepod abundance and dominance decreased consistently with the oxygen gradient. The pattern of meiofauna biomass was similar to that of abundance. The correlation analysis of the meiofauna numbers and environmental parameters indicated that abundance and biomass of total meiofauna and nematodes had significant or highly significant (P<0.05 or P<0.01) correlations with Chl a and Pha a, but no significant (P>0.05) correlations with bottom-water oxygen (BWO2). On the other hand, there was a highly significant positive correlation between benthic copepod abundance and bottom-water oxygen (P<0.05). The investigation on the nematode community structure indicated that two different nematode communities existed in hypoxic and anoxic areas. In certain way, the shift in nematode species composition distinguishes the anoxia to hypoxia. Nematode diversity was generally lower within the anoxic stations than the hypoxic ones, but the difference was not significant. Indices of the nematode community structure varied in relation to the bottom-water oxygen together with bottom-water temperature, Chl a concentration and median grain size of sediment. | HUA Er ZHANG Zhinan ZHANG Yan | 2006 | Acta Oceanologica Sinica2006，25，5： | 11 |
| 15 | 磨损颗粒刺激巨噬细胞引起人工关节松动的作用机制显示文摘目的探讨来源于人外周血的单核/巨噬细胞对直径1μm以下超高分子聚乙烯(UHMWPE)磨损颗粒的反应及其机制。方法从因无菌性人工髋关节松动而需要行翻修手术的患者假体周围组织中提取UHMWPE磨损颗粒。从10名健康志愿者分别抽取50ml外周血,梯度离心获得外周血中的单核/巨噬细胞。将细胞分为6组:A:单核/巨噬细胞+UHMWPE磨损颗粒;B:单核/巨噬细胞+UHMWPE磨损颗粒+100μMRote-none;C:单核/巨噬细胞+UHMWPE磨损颗粒+10μMU0126;D:单核/巨噬细胞+UHMWPE磨损颗粒+10ng/mlCerivastatin;E:单核/巨噬细胞;F:单核/巨噬细胞+脂多糖(LPS)。检测各组细胞的TNFα表达。结果UHMWPE磨损颗粒明显刺激单核/巨噬细胞分泌TNFα。Rotenone、U0126和Cerivastatin均可抑制UHMWPE磨损颗粒刺激单核/巨噬细胞分泌TNFα,且以U0126明显(P<0.01)。结论UHMWPE磨损颗粒刺激单核/巨噬细胞产生TNFα可通过NF-κB和MAPK通路,但以MAPK通路为主。 | 丁悦 秦础强 马若凡 许杰 刘尚礼 Barden Bertram Ler Franz | 2008 | 中华关节外科杂志(电子版)2008，2，4： | 11 |
| 16 | Phage display screening of therapeutic peptide for cancer targeting and therapy显示文摘Recently,phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018.Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on phage in a combinatorial library and could be further enriched through the biopanning process;proving to be a powerful technique in the screening of peptide with high affinity and selectivity.In this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands by in situ,in vitro,in vivo,and ex vivo screening methods.We will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display screening.We will also discuss the current challenges and future outlook for targeting peptidebased therapeutics in the clinics. | Phei Er Saw Er-Wei Song | 2019 | Protein & Cell2019，10，11： | 11 |
| 17 | Anycast service model and its QoS routing algorithm显示文摘In the Internet, a group of replicated servers is commonly used in order to improve the scalability of network service. Anycast service is a new network service that can improve network load distribution and simplify certain applications. In this paper, the authors described a simple anycast service model in the Internet without significant affecting the routing and protocol processing infrastructure that was already in place, and proposed an anycast QoS routing algorithm for this model. The algorithm used randomized method to balance network load and improve its performance. Several new techniques are proposed in the algorithm, first, theminimum hops for each node are used in the algorithm, which are used as metric for computing the probability of possible out links. The metric is pre computed for each node in the network, which can simplify the network complexity and provide the routing process with useful information. Second, randomness is used at the link level and depends dynamically on the routing configuration. This provides great flexibility for the routing process, prevents the routing process from overusing certain fixed routing paths, and adequately balances the delay of the routing path. the authors assess the quality of QoS algorithm in terms of the acceptance ratio on anycast QoS requests, and the simulation results on a variety of network topologies and on various parameters show that the algorithm has good performances and can balance network load effectively. | WANG Jian xin, CHEN Song qiao, CHEN Jian er (College of Information Science and Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 11 |
| 18 | Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices显示文摘 | Lu - Ying Liu Er - Qing Wei Yan- Min Zhao Fang - Xue Chen Meng - Ling Wang Wei - Ping Zhang Zhong Chen | 2005 | 中国药理通讯2005，22，4： | 11 |
| 19 | Study on bed load transport for uniform sediment in laminar flow显示文摘Previous studies focused on the bed load transport rate for the condition of turbulent flow,while the knowledge of sediment transport in laminar flow is very limited.As an extreme case to reflect the viscous effect on sediment transport,sediment transport in laminar flow is considered in this paper.There are at least two factors affecting the transport rate of sediment under laminar flow conditions: (1) fluid forces;(2) particle to particle interactions.Together,these two factors represent the physical transport system.First,an exposure degree Probability Density Function (PDF) is developed to explore how the transport rate can be associated with characteristics of laminar flow and this factor reflects the particle to particle interactions,and the pickup probability equation in the absence of turbulence is developed based on the stochastic approach which reflects the exposure degree influence.Then,the formulas to calculate the critical shear stress of incipient motion and the bed load transport rate of fine uniform sediment are established.The derivation is made mainly based on Einstein’s bed load theory;we choose Einstein’s equation to model this system because we believe that the probabilistic approach taken is an appropriate way to account for the spatial and temporal variations in the forces causing sediment transport.These formulas have been tested against a wide range of existing laboratory data and compared with other existing empirical or semiempirical methods.The predictions by these newly proposed formulas are very good. | YANG FengGuang,LIU XingNian,CAO ShuYou,YANG KeJun & HUANG Er State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu 610065,China | 2010 | Science China(Technological Sciences)2010，53，9： | 9 |
| 20 | Changes in Temporal Concentration Property of Summer Precipitation in China during 1961–2010 Based on a New Index显示文摘Based on the property of entropy,a new index Q was defined to measure the temporal concentration property of summertime daily rainfall in China,based on daily precipitation data collected at 553 observation stations in China during 1961–2010.Furthermore,changes in the temporal concentration property of summer precipitation in China were investigated.The results indicate that the regions with larger Q values were located in most parts of Northwest China and the north of the Yellow River,where daily precipitation tended to become temporally concentrated during the study period.On the contrary,smaller Q values were found in eastern Tibetan Plateau,southeastern Northwest China,and most parts of Southwest and South China.The most obvious increasing trend of Q index was found in South China and most parts of Southwest China,where precipitation showed a temporal concentration trend.However,a decreasing trend of Q index was found in Northwest China,the Tibetan Plateau,and the north of the Huaihe River.Variations of the Q index and the summer rainfall total during 1961–2010 in China both exhibited an increasing trend,implying larger temporal variability in rainfall attributes.It is illustrated that the summer precipitation in general became more temporally concentrated with more intense rainfall events and wetter days. | Hui LI Panmao ZHAI Er LU Wei ZHAO Yang CHEN Huan WANG | 2017 | Journal of Meteorological Research2017，31，2： | 9 |
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