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| 1 | Could the burden of pancreatic cancer originate in childhood?显示文摘The presence of pancreatic cancer during childhood is extremely rare,and physicians may be tempted to overlook this diagnosis based on age criteria.However,there are primary malignant pancreatic tumors encountered in pediatric patients,such as pancreatoblastoma,and tumors considered benign in general but may present a malignant potential,such as the solid pseudo-papillary tumor,insulinoma,gastrinoma,and vasoactive intestinal peptide secreting tumor.Their early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these conditions.Many pediatric cancers may present pancreatic metastases,such as renal cell carcinoma,which may evolve with pancreatic metastatic disease even after two or more decades.Several childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood;hence,there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult healthcare.Nevertheless,genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic cancer.This review aims to report the main pancreatic cancers diagnosed during childhood,the most important childhood diseases predisposing to the development of pancreatic malignancies,and the gene mutations associates with pancreatic malignant tumors. | Smaranda Diaconescu Georgiana Emmanuela Gîlcă-Blanariu Silvia Poamaneagra Otilia Marginean Gabriela Paduraru Gabriela Stefanescu | 2021 | World Journal of Gastroenterology2021，27，32： | 3 |
| 2 | Split-dose or hybrid nonsteroidal anti-inflammatory drugs and Nacetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis显示文摘BACKGROUND Despite significant technical and training improvements, the incidence of postendoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g. nonsteroidal anti-inflammatory drugs, octreotide,antioxidants, administered via various dosages, routes(oral, intrarectal or parenteral), and schedules(before or after the procedure), the results have been conflicting.AIM To evaluate efficacy of three pharmacologic prophylactic methods for prevention of PEP.METHODS In this prospective, single-center randomized trial, patients who underwent firsttime ERCP for choledocholithiasis were randomly assigned to three groups. The first group received 600 mg N-acetylcysteine 15 min prior to ERCP, and perrectum administration of 50 mg indomethacin both prior to and after completion of the ERCP. The second group was administered only the 50 mg indomethacin per-rectum both prior to and after the ERCP. The third group was administeredper-rectum 100 mg indomethacin only after the ERCP, representing the control group given the guideline-recommended regimen. The primary end-point was PEP prevention.RESULTS Among the total 211 patients evaluated during the study, 186 fulfilled the inclusion criteria and completed the protocol. The percentages of patients who developed PEP in each of the three groups were not significantly different(χ2 =2.793, P = 0.247). Among the acute PEP cases, for all groups, 14 patients developed mild pancreatitis(77.77%) and 4 moderate. No severe cases of PEP occurred, and in all PEP cases the resolution was favorable. No adverse events related to the medications(digestive hemorrhage, rectal irritation, or allergies)occurred.CONCLUSION The efficacies of split-dose indomethacin and combined administration(Nacetylcysteine with indomethacin) for preventing PEP were similar to that of the standard regimen. | Laura Pavel Gheorghe Gh Balan Alexandra Nicorescu Georgiana Emmanuela Gilca-Blanariu Catalin Sfarti Stefan Chiriac Smaranda Diaconescu Vasile Liviu Drug Gheorghe Balan Gabriela Stefanescu | 2019 | World Journal of Clinical Cases2019，7，3： | 3 |
| 3 | Psychological Distress of Patients With Advanced Cancer: Influence and Contribution of Pain Severity and Pain Interference显示文摘 | Kyriaki Mystakidou Eleni Tsilika Efi Parpa Emmanuela Katsouda Antonis Galanos Lambros Vlahos | 2006 | Cancer Nursing2006，，： | 1 |
| 4 | Effectiveness of diabetes and hypertension management by rural primary health - care workers ( Behvars workers) in Irma: a nationally representative observational study 显示文摘 | Farshad Farzadfar Christopher J L Murray Emmanuela Gakidou | 2012 | Lancet2012，，7： | 1 |
| 5 | Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy显示文摘 | Barry J. Maron Paolo Spirito Michael J. Ackerman Susan A. Casey Christopher Semsarian N.A. Mark Estes Kevin M. Shannon Euan A. Ashley Sharlene M. Day Giuseppe Pacileo Francesco Formisano Emmanuela Devoto Aristidis Anastasakis J. Martijn Bos Anna Woo Camil | 2013 | Journal of the American College of Cardiology2013，，14： | 1 |
| 6 | Heats of combustion and formation of new energetic thermoplastic elastomers based on GAP,PolyNIMMO and PolyGLYN显示文摘 | Emmanuela Diaz Patrick Brousseau Guy Ampleman | 2003 | Propellants Explosives Pyrotechnics2003，28，3： | 1 |
| 7 | China’s health system performance显示文摘 | Yuanli Liu Keqin Rao Jing Wu Emmanuela Gakidou | 2008 | The Lancet2008，，9653： | 1 |
| 8 | Investigation of the flow field in a three-dimensional confined impinging jets reactor by means of microPIV and DNS显示文摘 | lcardi Matteo Gavi Emmanuela Marchisio Daniele L | 2011 | Chemical Engineering Journal2011，166，： | 1 |
| 9 | Measuring total health inequality= adding individual variation to group-level differences 显示文摘 | Emmanuela G Gary K | 2002 | Int J Equ Health2002，1，3： | 1 |
| 10 | Prevention of cardiowascular disease in high-risk individuals in low- income and middle-income countries : health eft cts and costs 显示文摘 | Stephen S Lim Thomas A Gaziano Emmanuela Gakidou | 2007 | Lancet2007，32，370： | 1 |
| 11 | Assessing the effect of the 2001–06 Mexican health reform: an interim report card显示文摘 | Emmanuela Gakidou Rafael Lozano Eduardo González-Pier Jesse Abbott-Klafter Jeremy T Barofsky Chloe Bryson-Cahn Dennis M Feehan Diana K Lee Hector Hernández-Llamas Christopher JL Murray | 2006 | The Lancet2006，，9550： | 1 |
| 12 | Benchmarking of performance of Mexican states with effective coverage显示文摘 | Rafael Lozano Patricia Soliz Emmanuela Gakidou Jesse Abbott-Klafter Dennis M Feehan Cecilia Vidal Juan Pablo Ortiz Christopher JL Murray | 2006 | The Lancet2006，，9548： | 1 |
| 13 | Effectiveness of diabetes and hypertensionmanagement by rural primary health - care workers (Behvarz workers) in Iran: a nationally representative observational study 显示文摘 | Farshad Farzadfar Christopher J L Murry Emmanuela Gakidou | 2012 | lancet2012，，7： | 1 |
| 14 | Randomized, open label, prospective study on the effect of zoledronic acid on the prevention of bone metastases in patients with recurrent solid tumors that did not present with bone metastases at baseline显示文摘 | Kyriaki Mystakidou Emmanuela Katsouda Efi Parpa Alexis Kelekis Antonis Galanos Lambros Vlahos | 2005 | Medical Oncology2005，，： | 1 |
| 15 | Increased Educational Attainment and Its Effect on Child Mortality in 175 Countries between 1970 and 2009: A Systematic Analysis 显示文摘 | Emmanuela Gakidou Krycia Cowling Rafael Lozano Christopher J L | 2010 | The Lancet2010，367，18： | 1 |
| 16 | Randomized, open label, prospective study on the effect of zoledronic acid on the prevention of bone metastases in patients with recurrent solid tumors that did not present with bone metastases at baseline显示文摘 | Kyriaki Mystakidou MD PhD Emmanuela Katsouda Efi Parpa Alexis Kelekis Antonis Galanos Lambros Vlahos | 2005 | Medical Oncology2005，，2： | 1 |
| 17 | Heats of Combustion and Formation of New Energetic Thermoplastic Elastomers Based on GAP, PolyNIMMO and PolyGLYN显示文摘 | Emmanuela Diaz | 2003 | Propellants Explosives Pyrotechnics2003，28，3： | 1 |
| 18 | Polymer nanocomposites from energetic thermoplastic elasto-mer and Alex 显示文摘 | Emmanuela Diaz Patrick Brousseau Guy Ampleman | 2003 | Propellants Explosives Pyrotechnics2003，28，4： | 1 |
| 19 | Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: health effects and costs显示文摘 | Stephen S Lim Thomas A Gaziano Emmanuela Gakidou K Srinath Reddy Farshad Farzadfar Rafael Lozano Anthony Rodgers | 2007 | The Lancet2007，，9604： | 1 |
| 20 | 中国卫生系统绩效测量显示文摘以卫生系统服务覆盖率和灾难性医疗支出为主要指标,我们全面建立了一套国家层面及省级层面上的中国卫生系统绩效测量体系,并利用现有数据进行了测量.结果表明:在卫生服务提供方面,中国的妇幼保健工作成效显著,而在非传染性疾病控制方面则还存在不足,例如,农村妇女的住院分娩率从1993年的20.0%显著提高到2003年的61.9%。但是,2004年高血压的有效治疗率在城市地区仍低至11.7%,农村地区也仅为7.0%。从卫生服务可负担性来看,2003年城市地区13.8%的家庭以及农村地区15.8%的家庭发生了灾难性医疗支出。此外,15.1%的城市居民和21.6%的农村居民在利用卫生服务时遇到过经济困难。虽然从1993年到2003年卫生系统服务覆盖率无论城乡都有所提高,但农村地区的卫生服务可负担性问题似乎有所恶化,同时,无论是卫生系统服务覆盖率还是卫生服务可负担性,测量结果都显示出不同地区之间和同一地区内部均存在显著的不平等现象。低收入人群不仅卫生系统服务覆盖率更低,而且有病不去就医或者发生灾难性医疗支出的概率也更高。总之,为了更好地评价中国当前卫生系统改革的成效,必须要紧密结合绩效指标测量,而在这方面仍存在数据不足的问题。 | Yuanli Liu Keqin Rao Jing Wu Emmanuela Gakidou | 2009 | 世界临床医学2009，3，2： | 1 |
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