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| 1 | Clinical epidemiology and disease burden of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis(NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma(HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type Ⅱ diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear toexperience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis. | Brandon J Perumpail Muhammad Ali Khan Eric R Yoo George Cholankeril Donghee Kim Aijaz Ahmed | 2017 | World Journal of Gastroenterology2017，23，47： | 70 |
| 2 | Cholecystectomy is independently associated with nonalcoholic fatty liver disease in an Asian population显示文摘AIM: To investigate the relationship between gallstone disease and nonalcoholic fatty liver disease(NAFLD) in a large Asian population. METHODS: A cross-sectional study including 17612 subjects recruited from general health check-ups at the Seoul National University Hospital, Healthcare System Gangnam Center between January 2010 and December 2010 was conducted. NAFLD and gallstone disease were diagnosed based on typical ultrasonographic findings. Subjects who were positive for hepatitis B or C, or who had a history of heavy alcohol consumption(> 30 g/d for men and > 20 g/d for women) or another type of hepatitis were excluded. Gallstone disease was defined as either the presence of gallstones or previous cholecystectomy, and these two entities(gallstones and cholecystectomy) were analyzed separately. Clinical parameters including body mass index, waist circumference, hypertension, diabetes, smoking status, and regular physical activity were reviewed. Laboratory parameters, including serum levels of gamma-glutamyl transpeptidase, alanine aminotransferase, aspartate aminotransferase, fasting glucose, fasting insulin, total cholesterol, triglycerides, and high-density lipoprotein, were also reviewed.RESULTS: The mean age of the subjects was 48.5± 11.3 years, and 49.3% were male. Approximately 30.3% and 6.1% of the subjects had NAFLD and gallstone disease, respectively. The prevalence of gallstone disease(8.3% vs 5.1%, P < 0.001), including both the presence of gallstones(5.5% vs 3.4%, P < 0.001) and a history of cholecystectomy(2.8% vs 1.7%, P < 0.001), was significantly increased in the NAFLD group. In the same manner, the prevalence of NAFLD increased with the presence of gallstone disease(41.3% vs 29.6%, P < 0.001). Multivariate regression analysis showed that cholecystectomy was associated with NAFLD(OR = 1.35, 95%CI: 1.03-1.77, P = 0.028). However, gallstones were not associated with NAFLD(OR = 1.15, 95%CI: 0.95-1.39, P = 0.153). The independent association between cholecystectomy and NAFLD was still significant after additional adjustment for insulin resistance(OR = 1.45, 95%CI: 1.01-2.08, P = 0.045). CONCLUSION: This study shows that cholecystectomy, but not gallstones, is independently associated with NAFLD after adjustment for metabolic risk factors. These data suggest that cholecystectomy may be an independent risk factor for NAFLD. | Min-Sun Kwak Donghee Kim Goh Eun Chung Won Kim Yoon Jun Kim Jung-Hwan Yoon | 2015 | World Journal of Gastroenterology2015，21，20： | 11 |
| 3 | Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease显示文摘 | Jeong-Hoon Lee Donghee Kim Hwa Jung Kim Chang-Hoon Lee Jong In Yang Won Kim Yoon Jun Kim Jung-Hwan Yoon Sang-Heon Cho Myung-Whun Sung Hyo-Suk Lee | 2009 | Digestive and Liver Disease2009，，7： | 4 |
| 4 | Association of visceral obesity and early colorectal neoplasia显示文摘AIM:To examine whether visceral adipose tissue(VAT)serves as a risk factor for colorectal adenoma-early colorectal cancer(CRC)sequence.METHODS:A retrospective case-control study was conducted with 153 patients with stageⅠCRC,age/sex-matched 554 patients with colorectal adenoma and557 normal controls.All subjects underwent various laboratory tests,abdominal fat computed tomography(CT),and colonoscopy.VAT was defined as an intraabdominal adipose tissue area measured by CT scan.Adipose tissue area was measured at the level of the umbilicus from CT scan.We used the lowest quartile of VAT and subcutaneous adipose tissue area as a reference group.RESULTS:The body mass index(BMI),total cholesterol,fasting glucose and VAT areas were significantly different among normal,adenoma and CRC groups.The VAT area was 120.6±49.0 cm2in normal controls,130.6±58.4 cm2in adenoma group and 117.6±51.6cm2in CRC group(P=0.002).In univariate analysis,increased BMI was a risk factor for CRC compared to control(P=0.025).However,VAT area was not a risk factor for CRC compared to control.In multivariate analysis that adjusted for smoking,alcohol consumption and subcutaneous adipose tissue area,VAT area was inversely related to CRC,compared to the adenoma(OR=0.53,95%CI:0.31-0.92,highest quartile vs lowest quartile).CONCLUSION:Our study shows that visceral obesity is not a risk factor for early CRC.Visceral obesity might influence the normal-adenoma sequence but not the adenoma-early carcinoma sequence. | Eun Kyung Choe Donghee Kim Hwa Jung Kim Kyu Joo Park | 2013 | World Journal of Gastroenterology2013，19，45： | 4 |
| 5 | New hope for hepatitis C virus:Summary of global epidemiologic changes and novel innovations over 20 years显示文摘Hepatitis C virus(HCV)is a global health concern associated with significant morbidity and mortality.Before the approval of second-generation direct-acting antiviral agents(DAAs),interferon therapy and liver transplantation constituted the mainstay of treatment.The introduction of well-tolerated oral DAAs in late 2013 has revolutionized HCV management with over 95%cure rates.The predominance of HCV-related liver transplantations has declined following the widespread approval of DAAs.Despite the unparallel efficacy observed among these novel therapies,pharmaceutical costs continue to limit equitable access to healthcare and likely contribute to the differential HCV infection rates observed globally.To reduce the burden of disease worldwide,essential agenda items for all countries must include the prioritization of integrated care models and access to DAAs therapies.Through transparent negotiations with the pharmaceutical industry,the consideration for compassionate release of medications to promote equitable division of care is paramount.Here we provide a literature review of HCV,changes in epidemiologic trends,access issues for current therapies,and global inequities in disease burden. | Brittany B Dennis Leen Naji Yasmin Jajarmi Aijaz Ahmed Donghee Kim | 2021 | World Journal of Gastroenterology2021，27，29： | 4 |
| 6 | Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: Noninvasive Assessment with MR Elastography显示文摘 | Donghee Kim W. Ray Kim Jayant A. Talwalkar Hwa Jung Kim Richard L. Ehman | 2013 | Radiology2013，，2： | 3 |
| 7 | Development of a new Cr(VI)-biosorbent from agricultural biowaste显示文摘 | Donghee Park Seong-Rin Lim Yeoung-Sang Yun Jong Moon Park | 2008 | Bioresource Technology2008，，18： | 2 |
| 8 | Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis显示文摘 | Seung Joo Kang Donghee Kim Hyo Eun Park Goh Eun Chung Seung Ho Choi Su-Yeon Choi Whal Lee Joo Sung Kim Sang-Heon Cho | 2013 | Atherosclerosis2013，，： | 2 |
| 9 | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism显示文摘 | Goh Eun Chung Donghee Kim Won Kim Jeong Yoon Yim Min Jung Park Yoon Jun Kim Jung-Hwan Yoon Hyo-Suk Lee | 2012 | Journal of Hepatology2012，，1： | 2 |
| 10 | Nonalcoholic fatty liver disease is associated with coronary artery calcification显示文摘 | Donghee Kim Su‐Yeon Choi Eun Ha Park Whal Lee Jin Hwa Kang Won Kim Yoon Jun Kim Jung‐Hwan Yoon Sook Hyang Jeong Dong Ho Lee Hyo‐suk Lee Joseph Larson Terry M. Therneau W. Ray Kim | 2012 | Hepatology2012，，2： | 2 |
| 11 | Chemical treatment for treating cyanides-containing effluent from biological cokes wastewater treatment process 显示文摘 | Donghee Park Dae Sung Lee Young Mo Kim | 2008 | Chemical Engineering Joumal2008，143，： | 1 |
| 12 | Mechanism of hexavalent chromium removal by dead fungal biomass of Asperginus niger显示文摘 | Donghee P Yeoung-S Y Jong Moon P | 2005 | Water Reseach2005，39，： | 1 |
| 13 | Gross-entrainment behavior of turbulent jets injected obliquely into a uniform crossflow 显示文摘 | Donghee H Orozco V Mungal M G | 2000 | AIAA J2000，38，9： | 1 |
| 14 | A novel adaptive beamforming algorithm for a smart antenna system in a CDMA mobile communication environment显示文摘 | Seungwon Choi Donghee shim | 2000 | Vehicular Technology IEEE Transactions on2000，49，5： | 1 |
| 15 | Effect of HRT on the biological pre-denitrification process for the simultaneous removal of toxic pollutants from cokes wastewater显示文摘 | Young Mo Kim Donghee Park Che Ok Jeon Dae Sung Lee Jong Moon Park | 2008 | Bioresource Technology2008，，18： | 1 |
| 16 | A novel adaptive beamforming algorithm for a smart antenna system in a CDMA mobile communication environment显示文摘 | Seungwon Choi Donghee shim | 2000 | IEEE Transactions on Vehicular Technology2000，49，5： | 1 |
| 17 | Personal records on the web: Who's in charge of archiving, Hotmail or archivists? 显示文摘 | Sinn Donghee Syn Sue Yeon Kim Sung-Min | 2011 | Library & Information Science Research2011，33，4： | 1 |
| 18 | LRFU:a spectrum of policies that subsumes the least recently used and least frequently used policies 显示文摘 | Donghee Lee | 2001 | IEEE Transactions on Computers2001，50，12： | 1 |
| 19 | Studies onhexavalent chromium biosorption by chemically-treated biomass of Ecklonia sp 显示文摘 | Donghee Park Yeoung Sang Yun JongMoon Park | 2005 | Chemosphere2005，，60： | 1 |
| 20 | A novel adaptive beamforming algorithm for a smart antenna system in a CDMA mobile communication environment 显示文摘 | Shim Donghee | 2000 | IEEE Transaction on Vehicular Technology2000，49，5： | 1 |
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