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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Characterization of major histocompatibility complex class Ⅱ A and B genes in gynogenetic carp clone显示文摘 | Van Erp S H M Egberts E Stet R | 1996 | Immunogenetics1996，44，3： | 1 |
| 5 | TOPEX/POSEIDON tides estimated using a global inverse model显示文摘 | Egbert G D Bennett A Foreman M | 1994 | J Geophys Res1994，99，24： | 1 |
| 6 | Reducing depression in stroke survivors and their informal caregivers: a randomized clinical trial of a Web-based intervention显示文摘 | Smith GC Egbert N Dellman-Jenkins M | 2012 | Re- habil Psychol2012，57，3： | 1 |
| 7 | Can adverse drug reactions be detected earlier? A comparison by patients and professionals 显示文摘 | Egberts T C Smulders M Koning F H | 1996 | BMJ1996，313，7056： | 1 |
| 8 | Signal selection and lbllow-up in pharmacovigilance 显示文摘 | Meyboom R H Lindquist M Egberts A C | 2002 | Drug Saf2002，25，6： | 1 |
| 9 | The matricellular protein periostin contributes to proper collagen function and is downregu- lated during skinaging显示文摘 | Egbert M Ruetze M Sattler M | 2014 | J Dermatol Sei2014，73，1： | 1 |
| 10 | A simple conjunctival biop- sy显示文摘 | Egbert P R Lauber S Maurice D M | 1977 | Am J Ophthalmol1977，84，6： | 1 |
| 11 | Response of enzyme activities to nitrogen addition in forest floors of different C-to-N ratios显示文摘 | KERSTIN M EGBERT M | 2003 | Biol Fertil Soils2003，38，2： | 1 |
| 12 | Comparative study of YKL-40, S-100B and LDH as monitoring tools for Stage IV melanoma 显示文摘 | EGBERTS F KOTTHOFF E M GERDES S | 2012 | Eur J Cancer2012，48，5： | 1 |
| 13 | Clinical characteristics of patients with myositis and autoantibodies to different fragments of the Mi-2 beta antigen显示文摘 | Hengstman G J Vree Egberts W T Seelig H P Lundberg I E Moutsopoulos H M Doria A | 2006 | Ann Rheum Dis2006，65，： | 1 |
| 14 | Outcome analysis of minimally invasive repair of pectus excavatum: review of 251cases显示文摘 | Hebra A Swoveland B Egbert M | | 0，，： | 1 |
| 15 | Some interactional achievement of other-initiated repair in multiperson conversation显示文摘 | EGBERT M | 1997 | Journal of Pragmatics1997，27，5： | 1 |
| 16 | Guanidines with antihypertensive activity 显示文摘 | Mull R P Egbert M E Dapero M R | 1960 | J Org Chem1960，25，11： | 1 |
| 17 | TOPEX/POSEIDON Tides Estimated Using a Global Inverse Model显示文摘 | EGBERT G D BENNETT A F FOREMAN M G G | 1994 | Journal of Geophysical Research1994，99，24： | 1 |
| 18 | Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinsons disease显示文摘 | ARBOU W M E L MOVIG K L L EGBERTS T C G POELS P J E VAN VUGT J P P WESSELS J A M VAN DER STRAATEN R J H M NEEF C GUCHELAAR H J | 2009 | Eur J Clin Pharm2009，65，12： | 1 |
| 19 | Rapid detection of cutaneous herpes simplex virus infection with the polymerase chain reaction显示文摘 | Cao M Xiao X Egbert B | 1989 | J Invest Dermatol1989，82，： | 1 |
| 20 | Characterization of class Ⅱ A and B genes in a gynogenetie carp clone显示文摘 | Van Erp S H M Egberts E Stet R J M | | 0，，： | 1 |
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