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| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Comparison of four laser types for experimental pain stimulation on oral mucosa and hairy skin 显示文摘 | Svensson P Bjerring P Arendt-Nielsen L | 1991 | Lasers Surg Med1991，11，4： | 1 |
| 3 | Skin rejuvenation using intense pulsed light-a randomized controlled splitface trial with blinded response evaluation显示文摘 | Hedelund L Due E Bjerring P | 2006 | Arch Dermatol2006，142，： | 1 |
| 4 | 420 nm intense continuous light therapy for acne显示文摘 | Omi T Bjerring P Sato S | 2004 | J Cosmet Laser Tner2004，6，3： | 1 |
| 5 | Sensory and pain thresholds to orofacial argon laser stimulation in patients with chronic burning mouth syndrome显示文摘 | Svensson P Bjerring P Arendt-Nielsen L | 1993 | Clin J Pain1993，9，3： | 1 |
| 6 | Liposomes in dermatology today显示文摘 | De Leeuw J De Vijlder HC Bjerring P | | 0，，： | 1 |
| 7 | Cyto-kine and acute phase protein gene expression in repeat-ed liver biopsies of dairy cows with a lipopolysaccha-ride-induced mastitis 显示文摘 | VELS L R0NTVED C M BJERRING M | 2009 | Journal of Dairy Science2009，92，3： | 1 |
| 8 | 20nm intensec ontinuous light ther- apy foracne 显示文摘 | OmiT Bjerring PS AtoS et ah 14 | 2004 | J Cosmet Laser Ther2004，6，3： | 1 |
| 9 | 2011m intensec ontinuous light therapy foracne 显示文摘 | Omi T Bjerring PS Ato S | 2004 | J Cosmet Laser Ther2004，6，3： | 1 |
| 10 | Intense pulsed light source for treatment of facial telangiectasias 显示文摘 | Bjerring P Christiansen K Troilius A | 2001 | J Cosmet Laser Ther2001，3，4： | 1 |
| 11 | Intense pulsed light source for treatment of small melanocytic nevi and solar lentigines显示文摘 | Bjerring P Christiansen K | 2000 | Journal of Cutaneous Laser Therapy2000，2，4： | 1 |
| 12 | Selective nonablative wrinkle reduction by laser显示文摘 | Bjerring P Clement M Heickendorff L | 2000 | J Cut Laser Ther2000，2，： | 1 |
| 13 | Web services architecture for user control and management of optical internet networks 显示文摘 | B St Arnaud A Bjerring O Cherkaoui | 2004 | Proceedings of the IEEE2004，92，9： | 1 |
| 14 | Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects 显示文摘 | Haker E Egekvist I-I Bjerring P | 2000 | J Auto Nerv Syst2000，79，1： | 1 |
| 15 | Spectral reflectance of human skin in vivo显示文摘 | Bjerring P | 1990 | Photodermatol Photoimmunol Photomed1990，7，1： | 1 |
| 16 | Quarter health,milking interval,and sampling time during milking affect the concentration of milk constituents显示文摘 | Nielsen N I Larsen T Bjerring M | 2005 | J Dairy Sci2005，88，： | 1 |
| 17 | A comparative study of intense pulsed light alone and its combination with photodynamlc therapy for the treatment of facial acne in Asian skin 显示文摘 | Yeung CK Shek SY Bjerring P | 2007 | Lasers Surg Med2007，39，1： | 1 |
| 18 | Effect of sensory stimulation ( acu- puncture) on sympathetic and parasympathetic activities in healthy subjects显示文摘 | Haker E Egekvist H Bjerring P | 2000 | Auton Nerv Syst2000，79，1： | 1 |
| 19 | Impacts of climate warming on lake fish community structure and potential effects on ecosystem function显示文摘 | Jeppesen E Meerhoff M Holmgren K Gonzalez-Bergonzoni I Teixeira-de Mello F Declerck S A J De Meester L S?ndergaard M Lauridsen T L Bjerring R Conde-Porcuna J M Mazzeo N Iglesias C Reizenstein M Malmquist H J Liu Z W Balayla D Lazzaro X | 2010 | Hydrobiologia2010，646，1： | 1 |
| 20 | Sensory and Pain Threshold Characteristics to Laser Stimuli显示文摘 | ARENDT-NIELSEN L BJERRING P | 1988 | J Neurol Neurosurg Psychiatry1988，51，1： | 1 |
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