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| 1 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 2 | A Survey of Multi-robot Regular and Adversarial Patrolling显示文摘Multi-robot systems can be applied to patrol a concerned environment for security purposes.According to different goals,this work reviews the existing researches in a multi-robot patrolling field from the perspectives of regular and adversarial patrolling.Regular patrolling requires robots to visit important locations as frequently as possible and a series of deterministic strategies are proposed,while adversarial one focuses on unpredictable robots’moving patterns to maximize adversary detection probability.Under each category,a systematic survey is done including problem statements and modeling,patrolling objectives and evaluation criteria,and representative patrolling strategies and approaches.Existing problems and open questions are presented accordingly. | Li Huang MengChu Zhou Kuangrong Hao Edwin Hou | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，4： | 10 |
| 3 | A genetic algorithm for multiprocessor scheduling显示文摘 | Hou Edwin S H Nirwan Ansari Ren Hong | 1994 | IEEE Transactions on Parallel and Distributed Systems1994，5，2： | 1 |
| 4 | Genetic algorithm for multiprocessor scheduling显示文摘 | Edwin S H Hou Nirwan Ansari | 1994 | IEEE Trans on Parallel and Distributed Systems1994，5，2： | 1 |
| 5 | A genetic algorithm for multiprocessor scheduling 显示文摘 | Edwin S H Hou Nirwan Ansari Hong Ren | 1994 | IEEE Trans on Parallel and Distributed Systems1994，5，2： | 1 |
| 6 | Genetic Algorithm for Multiprocessor Scheduling显示文摘 | Edwin S Hou H Nirwan A nsari | 1994 | IEEE Trans on Parallel and Distributed Systems1994，5，2： | 1 |
| 7 | GeneTic algorithm for mulTiprocessor scheduling显示文摘 | Edwin S H Hou Nirwan Ansari | 1994 | IEEE Trans on Parallel and Distributed Systems1994，5，2： | 1 |
| 8 | A new method to optimize the satellite broadcasting schedules using the mean field annealing of a Hopfield networks显示文摘 | EDWIN S H HOU YOUYI YU | 1995 | IEEE Transaction on Neural Networks1995，6，2： | 1 |
| 9 | Genetic Algorithm for Multiprocessor Scheduling显示文摘 | Edwin S H Hou N An sari | 1994 | IEEE Trans on Parallel and Distributed Systems1994，5，11： | 1 |
| 10 | Optical parameters and upconversion fluorescence in Tm^3+/Yb^3+ -doped alkali-barium-bismuth-tellurite glasses 显示文摘 | Lin H Liu K Lin L Hou Y Yang D Ma T Y B P Edwin An Q Yu J Tanabe S | 2006 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2006，65，34： | 1 |
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