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| 1 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 2 | Morbidity and Mortality Analysis of 200 Treatments With Cytoreductive Surgery and Hyperthermic Intraoperative Intraperitoneal Chemotherapy Using the Coliseum Technique显示文摘 | Arvil D. Stephens MD Robert Alderman PA-C David Chang MD Gary D. Edwards PA-C Jesus Esquivel MD Gilbert Sebbag MD Mark A. Steves MD Paul H. Sugarbaker MD | 1999 | Annals of Surgical Oncology1999，，8： | 5 |
| 3 | Prevalence of fatty liver in Japanese children and relationship to obesity显示文摘 | Kunihiko Tominaga MD Dr Ph John H. Kurata PhD Dr. Yang K. Chen MD Edward Fujimoto DHSc MPH Shouhei Miyagawa Ichiro Abe MSA Yoshimasa Kusano BS | | Digestive Diseases and Sciences0，，： | 5 |
| 4 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani MD Sung W. Cho MD Christos Colovos MD PhD Songwon Seo MS Jan Franko MD PhD Scott D. Richard MD Robert P. Edwards MD Charles K. Brown MD PhD Matthew P. Holtzman MD Herbert J. Zeh MD David L. Bartlett MD | 2008 | Annals of Surgical Oncology2008，，3： | 2 |
| 5 | Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy With Mitomycin C for Peritoneal Carcinomatosis from Nonappendiceal Colorectal Carcinoma显示文摘 | Perry Shen MD Jason Hawksworth MD James Lovato PhD Brian W. Loggie MD Kim R. Geisinger MD Ronald A. Fleming PharmD Edward A. Levine MD | 2004 | Annals of Surgical Oncology2004，，2： | 2 |
| 6 | Reducing the Economic Burden of HPV-Related Diseases 显示文摘 | Edward John Mayeaux Jr MD | 2008 | J Am Osteopath Assoc2008，108，2： | 1 |
| 7 | Recalcitrant nonunion of the distal humerus:Treatment with free wascularized bonegrafting显示文摘 | Beredjiklian Pedro K MD Hotchkiss Robert N MD Athanasian Edward A MD | 2005 | Clin Orthop2005，435，： | 1 |
| 8 | Spontaneous Ruptureof the Stomach in a Healthy Adult Man After Sodium BicarbonateIngestion显示文摘 | Michael R Mastrangelo MD Edward W | 1984 | Ann Intern Med1984，101，5： | 1 |
| 9 | Haemophilus influenzae type b vaccines:history,choice and comparisons显示文摘 | Decker MD Edwards KM | 1998 | Pediatr Infect Dis J1998，17，9： | 1 |
| 10 | A computer-assisted technique for 24-hour esophageal monitoring显示文摘 | Rebecca B. Troxell PA-C Sarah R. Kohn BA Dr. James E. Gray MD Richard W. Welch MD Edward D. Harloe BS Raj K. Goyal MD | 1982 | Digestive Diseases and Sciences1982，，12： | 1 |
| 11 | De- velopment and validation of the new international classification for scapula fractures显示文摘 | Edward Harvey MD Laurent Audige MD Dolfi Herscovici | 2012 | Orthop Trauma2012，26，： | 1 |
| 12 | Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass (A randomized trial) 显示文摘 | Edward D Verrier MD Stanton K | 2004 | JAMA2004，291，： | 1 |
| 13 | Endothelial cell injury in cardiovascular surgery: The Pathophysiology of vasomotor dysfunction 显示文摘 | Frank W Sellke MD Edward M | 1996 | Ann Thorac Surg1996，62，： | 1 |
| 14 | Chemoprevention of Cancer显示文摘 | Anne S Tsao MD Edward SK | 2004 | CA Cancer J Clin2004，54，： | 1 |
| 15 | Autoimmune hepatitis显示文摘 | Edward L Krawitt MD | 2006 | N Engl J Med2006，354，： | 1 |
| 16 | Morbidity and Mortality Assessment of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Diffuse Malignant Peritoneal Mesothelioma—A Prospective Study of 70 Consecutive Cases显示文摘 | Tristan D. Yan BSc (Med) MBBS Gary Edwards PA-C Robert Alderman PA-C Christina E. Marquardt RN Paul H. Sugarbaker MD | 2007 | Annals of Surgical Oncology2007，，2： | 1 |
| 17 | Intraperitoneal hyperthermic perfusion with mitomycin C for colorectal cancer with peritoneal metastases显示文摘 | Dr. Schlomo Schneebaum MD Mark W. Arnold MD Alfred Staubus PhD Donn C. Young PhD David Dumond BS Edward W. Martin MD | 1996 | Annals of Surgical Oncology1996，，1： | 1 |
| 18 | Significance of micrometastases in colorectal cancer显示文摘 | Robert J. Feezor MD Edward M. Copeland MD Steven N. Hochwald MD | 2002 | Annals of Surgical Oncology2002，，10： | 1 |
| 19 | The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy显示文摘 | Sandra L. Wong MD Michael J. Edwards MD Celia Chao MD Todd M. Tuttle MD R. Dirk Noyes MD David J. Carlson MD Alison L. Laidley MD Terre Q. McGlothin MD Philip B. Ley MD C. Matthew Brown MD Rebecca L. Glaser MD Robert E. Pennington MD Peter S. Turk MD Dian | 2002 | Annals of Surgical Oncology2002，，3： | 1 |
| 20 | Foster children with special needs:the children's aid society experience显示文摘 | Angela Diaz MD Sharon Edwards MD | 2004 | The Mount Sinai Journal Of Medicine2004，，71： | 1 |
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