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| 1 | ERK1/2通路参与ET_A和ET_B受体介导的离体肠系膜上动脉收缩研究显示文摘目的探讨细胞外信号调节激酶1/2(ERK1/2)信号转导通路在内皮素1(ET-1)的两个G蛋白偶联受体ET_A和ET_B介导的收缩机制。方法用大鼠肠系膜上动脉器官培养模型,以敏感的离体药理学实验方法记录培养前后血管平滑肌张力,实时定量的PCR测定培养前后受体mRNA表达水平的变化。结果S6c不引起新鲜的肠系膜上动脉收缩,培养后ETB受体mRNA表达水平上调,介导的收缩明显增强(P<005);而ETA受体介导的收缩功能和mRNA均变化不大。低浓度的SB386023(10-5mol·L-1)降低S6c引起的最大收缩(Emax从239%±26%降至89%±13%,P<001),而对ET1引起的最大收缩并无影响(Emax271%±19%vs251%±16%,P>005);高浓度的SB386023(10-4mol·L-1)明显抑制ETA受体介导的收缩。结论ET-1通过ET_A受体介导新鲜动脉的收缩;动脉培养后表达ET_B受体;ERK1/2信号转导通路对ET_B受体的作用强于ET_A受体。 | 罗国刚 马爱群 徐仓宝 曹永孝 Lars Edvinsson | 2005 | 中国药理学通报2005，21，3： | 14 |
| 2 | Improved outcome with standardized plan for clinical management of acute decompensated chronic heart failure显示文摘Background Our overall goal is to improve clinical care for inpatients with chronic heart failure(CHF).A retrospective assessment of CHF patients admitted to our hospital over the past decade(2005 vs.2014)indicated a need for better strategies to evaluate clinical treatment,implement best practices and achieve optimal patient outcome.To that purpose,we developed a standardized plan to improve in-hospital treatment of acute decompensated CHF patients.Methods&Results Retrospective chart reviews were conducted to compare three cohorts of CHF patients admitted to the University Hospital of Lund at different time points over a 12-year period:2005(365 patients),2014(172 patients)and 2017-2018(57 patients).Little improvement was seen between 2005 and 2014 with respect to one-year mortality(35%vs.34%)and adequate treatment with recommended medications,e.g.,use of renin-angiotensin system blockers(45%vs.51%).A standardized treatment plan was devised to improve outcomes.A third cohort,treated under the plan(2017-2018),was compared with the 2014 cohort.One-year mortality(18%vs.34%)and 30-day readmission(5%vs.30%)were dramatically decreased,and adherence to medication guidelines was achieved.Key elements of the plan included well-defined treatment procedures,enhanced communication and teamwork,education,adequate time for treatment(5 days)and post-discharge follow-up as necessary.Natriuretic peptide(NT-proBNP)levels were useful for assessing patient status,prognosis and response to treatment.Conclusion Developmeof a standard plan for clinical management of acute decompensated CHF patients resulted in significant improvements in patient outcome,as reflected in decreased rates of 30-day readmission and one-year mortality. | Marie-Louise Edvinsson Albin Stenberg Karin Astrom-Olsson | 2019 | Journal of Geriatric Cardiology2019，16，1： | 13 |
| 3 | ALTERATION IN CONTRACTILE RESPONSE TO NORADRENALINE, 5-HYDROXYTRYPTAMINE, S ARAFOTOXIN 6c, AND ANGIOTENSINⅡ IN RAT MESENTERIC ARTERY DURING ORGAN CULTURE显示文摘Objective To compare the vasoconstrictive eff ects of 9 mediators on fresh and incubated mesenteric arteries of rats. Methods The superior mesenteric artery of rat was removed and t he endothelium was denuded. The vessels were cut into 1 mm long cylindrical segm ents and subjected to organ culture for 24 hours. Fresh or incubated segments we re immersed into tissue baths and the concentration-response curves were obtain ed by cumulative administration of the vasoconstrictors. Results In fresh mesenteric artery, endothelin-1 (ET-1), 5-h ydroxytryptamine (5-HT), noradrenaline (NA), 5-carboxamidotryptamine (5-CT), and angiotensinⅡ (AngⅡ) induced potent and sustained constrictions in a concen tration-dependent manner. The contraction induced by sarafotoxin 6c (S6c) was w eak, while bradykinin (BK), des-Arg-bradykinin (DA-BK), and human urotensinⅡ (hUT-II) showed no detectable contraction. The concentraion-response curves i n order of slopes was ET-1, NA, 5-HT, 5-CT, and AngⅡ. The order of the maxim um contractions was ET-1>NA=5-HT=5-CT>AngⅡ>S6c. After organ culture, the con centration-response curves induced by S6c, NA, and 5-HT were significantly inc reased, while that induced by AngⅡ was decreased as comparing to fresh arteries . BK contracted the artery only weakly. Conclusion Organ culture changed the phenotypes towards an increased efficacy of NA, 5-HT, S6c, and a reduced efficacy of AngⅡ, which is in accordance with the results o f pharmacological characterization in some human vascular disease. | 曹永孝 贺浪冲 徐仓宝 EDVINSSON Lars | 2004 | Journal of Pharmaceutical Analysis2004，16，2： | 8 |
| 4 | 阿托品对大鼠肠系膜动脉的舒张作用及机制显示文摘目的 研究阿托品的扩血管作用及机制。方法 以大鼠肠系膜动脉为标本,考察阿托品对去甲肾上腺素(NE)预收缩血管的舒张作用以及血管内皮细胞、血管平滑肌在该效应中的作用。结果 阿托品能显著舒张NE预收缩的完整内皮血管,去内皮后该作用明显降低。L Nω硝基精氨酸甲酯、吲哚美辛、普萘洛尔及格列本脲对阿托品的舒张作用无明显影响。阿托品对KCl的量效曲线及咖啡因缩血管作用均无明显影响,但能浓度依赖性地抑制NE诱导的内钙释放以及经受体操纵性钙通道的外钙内流。结论 阿托品有明显的扩血管作用,其通过抑制受体介导的外钙内流和内钙释放而舒张血管。 | 郑建普 曹永孝 徐仓宝 Lars Edvinsson | 2005 | 药学学报2005，40，5： | 5 |
| 5 | Brain natriuretic peptide is a potent vasodilator in aged human microcircula- tion and shows a blunted response in heart failure patients显示文摘BackgroundBrain natriuretic 肽(BNP ) 在在发行量的底层是通常在场的,但是它在心失败题目(CHF ) 与拥挤的度同时被提高。BNP 有 natriuretic 效果并且是有势力血管扩张药。BNP 能是在 CHF 的一种治疗学的选择,这被建议。然而,我们要求了在 CHF 的传播 BNP 的高水平可以 downregulate microvascular natriuretic 受体的反应。这被比较 15 个 CHF 病人测试(BNP >3000 ng/L ) 与 10 匹配的、健康 controls.MethodsCutaneous microvascular 血,在前臂的流动被激光 Doppler Flowmetry 测量。本地加热(+44 ° C, 10 min ) 被用来唤起一个最大的本地扩张器 BNP 或醋胆素(ACh ) 的 response.ResultsNon 侵略的 iontophoretic 管理,一个已知的内皮细胞层依赖者扩张器,在本地流动得到了增加。氮的氧化物 synthase 禁止者, l-N-Arginine- 甲基酉旨(L 名字) ,堵住了 BNP 反应(在控制) 。有趣地,对在 CHF 病人的 BNP 的回答被归结为在健康控制看见的大约三分之一那些(的增加流动:251% 在 CHF 对 908% 在控制;P <0.001 ) 。相反,对 ACh 并且到本地加热的血管扩张药回答仅仅有点在 CHF 病人被稀释。因此,发信号的扩张器能力和氮的氧化物没被影响到象调停 BNP 的膨胀的一样的程度,第一次显示后者 response.ConclusionsThe 调查结果表演的特定的 downregulation 对 BNP 的 microvascular 回答显著地在 CHF 病人被减少。这与 BNP 受体功能的假设一致是在 CHF 的 downregulated。 | Marie-Louise Edvinsson Erik Uddman Lars Edvinsson Sven E. Andersson | 2014 | Journal of Geriatric Cardiology2014，11，1： | 5 |
| 6 | Deteriorated function of cutaneous microcirculation in chronic congestive heart failure显示文摘背景长期的充血的心失败是在外部 microcirculation 导致机能障碍的一个复杂条件。我们以前证明了那脉管的反应与增加年龄被减少。在这研究,我们与严重的长期的心失败检查了一组很老的病人测试脉管的功能被心失败和老化的联合进一步损害的假设。方法皮肤的前臂血流动被激光 Doppler flowmetry 测量并且在三之中比较了组:组织 1 (n = 20,吝啬的 +/- SE:85.5 +/- 4 年) ,有纽约心协会班 IV (NYHA IV ) 并且与 NT-proBNP 的心失败病人铺平 5000 ng/L;组织 2 (n = 15,吝啬的 +/- SE:76.5 +/- 2 年) ,有 NYHA II 和 NT-proBNP 2000 ng/L 的心失败病人,和组 3 (n = 10,吝啬的 +/- SE:67.6 +/- 3.0 年) ,没有心失败的临床的符号的健康控制。对醋胆素(ACh ) 的 iontophoretic 管理的血管扩张药反应,经由 endothelial 机制,和钠 nitroprusside (SNP ) 行动,经由光滑的肌肉房间机制行动,被学习。结果当时,有心失败的所有病人显著地减少了刺激(ACh, SNP 或热) 的模式的脉管的反应独立人士与健康控制相比。然而,回答没在二组心失败病人之间不同。结论皮肤的脉管的反应在心失败病人被减少并且不与条件的严厉或病人的年龄相关。 | Marie-Louise Edvinsson Erik Uddman Sven E Andersson | 2011 | Journal of Geriatric Cardiology2011，8，2： | 4 |
| 7 | Calcitonin gene-related peptide-LI in SAH in man signs of activation of the trigemino cerebrovascular 显示文摘 | Juul R Edvinsson L Jisrole S | 1990 | Br J Neurosurg1990，4，3： | 2 |
| 8 | Developing a model for managing intellectual capital显示文摘 | Leif Edvinsson | 1996 | European Management Journal1996，，4： | 2 |
| 9 | 显示文摘 | Albers R Edvinsson Nystrm M Sellin A | 2001 | Catalysis Today2001，69，： | 2 |
| 10 | Perivascular neuropeptides(NPY,VIP,CGRP and SP)in human brain vessels after subarachnoid haemorrhage显示文摘 | EDVINSSON L JUUL R JANSEN I | 1994 | Acta Neurol Scand1994，90，5： | 2 |
| 11 | Hospital utilization and costs for spinal cord stimulation compared with enhanced external counterpulsation for refractory angina pectoris显示文摘 | Susanne M. Bondesson Ulf Jakobsson Lars Edvinsson Ingalill Rahm Hallberg | 2011 | Journal of Evaluation in Clinical Practice2011，，： | 2 |
| 12 | Intellectual capital of nations:for future wealth creation显示文摘 | EDVINSSON L STENFELT C | 1999 | Journal of Human Resource Costing & Accounting1999，4，1： | 1 |
| 13 | Developing a Model for Management Intellectual Capital显示文摘 | Lief Edvinsson Patrick Sullivan | 1996 | European Management Journal1996，，4： | 1 |
| 14 | Neurobiology in primary headaches显示文摘 | EDVINSSON L UDDMAN R | 2005 | Brain Res Brain Res Rev2005，48，3： | 1 |
| 15 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 16 | Calcitoningene related peptidein cervicogenic headache 显示文摘 | Frese A Schilgen M Edvinsson L | 2009 | Cephalalgia2009，7，： | 1 |
| 17 | Vasoactive peptide release in the extracerebral circulation of humans during migraine headache显示文摘 | Goadsby PJ Edvinsson L Ekman R | | 0，，： | 1 |
| 18 | National Intellectual Capital: Comparison of the Nordic Countries 显示文摘 | Lin C Y- Y Edvinsson L | 2008 | Jotmml of Intellectual Capital2008，9，4： | 1 |
| 19 | Hydrodynamics of gas-liquid countercurrent flow in internally-finned monolithic structures显示文摘 | Lebens P J M van der Meijden R Edvinsson R K Kapteyn F Sie S T Moulijn J A | 1997 | Chem Eng Sci1997，52，2122： | 1 |
| 20 | Intellectual Capital at Skandia显示文摘 | Edvinsson L | 1997 | Long Range Planning1997，30，3： | 1 |
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