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| 1 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 2 | Falls from height: A retrospective analysis显示文摘BACKGROUND: Emergency services manage trauma patients frequently and falls from height comprise the main cause of emergency service admissions. In this study, we aimed to analyse the demographic characteristics of falls from height and their relationship to the mortality.METHODS: A total of 460 patients, who admitted to the Emergency Department of Inonu University between November 2011 and November 2014 with a history of fall from height, were examined retrospectively. Demographic parameters, fall characteristics and their effect to mortality were evaluated statistically. RESULTS: The study comprised of 292(63.5%) men and 168(36.5%) women patients. The mean age of all patients was 27±24.99 years. Twenty-six(5.6%) patients died and the majority of them were in ≥62 years old group. The highest percentage of falls was at 0–5 years age group(28.3%). People fell mainly from 1.1–4 metres(m) level(46.1%). The causes of falls were ordered as unintentional(92.2%), workplace(8.1%) and suicidal(1.7%). Skin and soft tissue injuries(37.4%) were the main traumatic lesions. CONCLUSION: Age, fall height, fall place, linear skull fracture, subarachnoidal hemorrhage, cervical fracture, thoracic vertebra fracture and trauma scores had statistically significant effect on mortality. The casualties died because of subarachnoid hemorrhage mostly. | Kasim Turgut Mehmet Ediz Sarihan Cemil Colak Taner Giiven Ali Gur Sukru Gurbuz | 2018 | World Journal of Emergency Medicine2018，9，1： | 5 |
| 3 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 4 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 5 | Emergency Logistics Planning in Natural Disasters显示文摘 | Linet ?zdamar Ediz Ekinci Beste Kü?ükyazici | 2004 | Annals of Operations Research (-)2004，，1： | 3 |
| 6 | Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance显示文摘 | Ling Yang Ping Li Suneng Fu Ediz S. Calay G?khan S. Hotamisligil | 2010 | Cell Metabolism2010，，6： | 2 |
| 7 | Emergency logistics planning in natural disasters显示文摘 | Linet Ozdmar Ediz Ekinei Beste KU ctlkyaziei | 2004 | Annals of Operations Research2004，129，1： | 1 |
| 8 | Anatomic study of the vasculature of the submental artery flap 显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 9 | A color image segmentation approach for content-based image retrieval显示文摘 | Mustafa Ozden Ediz Polat | 2007 | Pattern Recognition2007，40，4： | 1 |
| 10 | Anatomy of vastus lateralis muscle flap显示文摘 | Tayfur V Magden O Edizer M | | 0，，： | 1 |
| 11 | Anatomic study of the vasculature of the submental artery flap显示文摘 | EDIZER M TAYFUR V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 12 | Microdynamics of the piezo driven pipettes in ICS显示文摘 | EDIZ K OLGAC N | 2004 | IEEE Transformation on Biomedical Engineering2004，51，7： | 1 |
| 13 | Emer-gency Logistics Planning in Natural Disasters显示文摘 | Linet Ozdamar Ediz Ekinci | 2004 | Annals of Operations Research2004，，： | 1 |
| 14 | Emergency logistics Planning in natural disasters 显示文摘 | LINET EDIZ & BESTE | 2004 | An- nals of Operations Researeh2004，，： | 1 |
| 15 | Determination of pollen- quantity, pollen viability and pollen germination in some dogrose species(Rosa section Caninae) 显示文摘 | Gunes M Cekic C Edizer Y | 2005 | Acta Horti-culturae2005，690，： | 1 |
| 16 | Emergency logistics planning in natural disasters显示文摘 | Linet O Ediz E Beste K | 2004 | Annals of Operations Research2004，129，7： | 1 |
| 17 | Emergency logisties planning in natural disasters显示文摘 | Linet Ozdamar Ediz Ekinci Beste Kucukyazici | 2004 | Annals of Operation Research2004，129，1： | 1 |
| 18 | Improvement in filtration characteristics of diatomite by calcination显示文摘 | EDIZ N BENTLI (I) TATAR (I) | | 0，，： | 1 |
| 19 | Emergency Logistics Planning in Natural Disasters显示文摘 | Linet ?zdamar Ediz Ekinci Beste Kü?ükyazici | 2004 | Annals of Operations Research (-)2004，，1： | 1 |
| 20 | The use of raw and calcined diatomite in cement production显示文摘 | YILMAZ B EDIZ N | | 0，，3： | 1 |
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