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| 1 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 2 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 3 | Anatomic study of the vasculature of the submental artery flap 显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 4 | Anatomy of vastus lateralis muscle flap显示文摘 | Tayfur V Magden O Edizer M | | 0，，： | 1 |
| 5 | Anatomic study of the vasculature of the submental artery flap显示文摘 | EDIZER M TAYFUR V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 6 | Determination of pollen- quantity, pollen viability and pollen germination in some dogrose species(Rosa section Caninae) 显示文摘 | Gunes M Cekic C Edizer Y | 2005 | Acta Horti-culturae2005，690，： | 1 |
| 7 | Anatomic bases of superficial temporal artery and temporal branch of facial nerve 显示文摘 | Tayfur V Edizer M Magden O | 2010 | J Craniofac Surg2010，21，6： | 1 |
| 8 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden O Edizer M Tayfur V | | Plastic and Reconstructive Surgery0，，： | 1 |
| 9 | Anatomic study of the vasculature of the submental artery flap显示文摘 | MAGDEN O EDIZER M TAYFUR V | 2004 | Plast Reconstr Surg2004，114，21： | 1 |
| 10 | Anatomic bases of superficial temporal artery and temporal branch of facial nerve 显示文摘 | TAYFUR V EDIZER M MAGDEN O | 2010 | J Craniofac Surg2010，21，6： | 1 |
| 11 | Anatomic bases of sup- erficial temporal artery and temporal branch of facial nerve 显示文摘 | Tayfur V Edizer M Magden O | 2010 | J Craniofac Surg2010，21，6： | 1 |
| 12 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Re- constr Surg2004，114，7： | 1 |
| 13 | Anatomic study of the vasculature of the submental artery flap 显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 14 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden 0 Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 15 | Seasonal disease activity and serum vitamin D levels in rheumatoid arthritis, ankylosing spondylitis and os- teoarthritis 显示文摘 | Yazmalar L Ediz L Alpayci M | 2013 | Aft Health Sci2013，13，1： | 1 |
| 16 | Arterial anatomy of the lower lip : a cadaveric study 显示文摘 | Edizer M Ma~den O Tayfur V | 2003 | Plast Reconstr Surg2003，111，7： | 1 |
| 17 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 18 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
| 19 | Seasonal disease ac3 tivity and serum vitamin D levels in rheumatoid arthritis,' ankylosing spondylitis and osteoarthritis显示文摘 | Yazmalar L Ediz L Alpayci M | 2013 | Afr Health Sci2013，13，1： | 1 |
| 20 | Anatomic study of the vasculature of the submental artery flap显示文摘 | Magden O Edizer M Tayfur V | 2004 | Plast Reconstr Surg2004，114，7： | 1 |
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