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| 1 | Progress in structural materials for aerospace systems 1 1 The Golden Jubilee Issue—Selected topics in Materials Science and Engineering: Past, Present and Future, edited by S. Suresh.显示文摘 | James C Williams Edgar A Starke | 2003 | Acta Materialia2003，，19： | 7 |
| 2 | A/E大肠杆菌疫苗动物模型的建立显示文摘致病性和出血性大肠杆菌 (代表株 EPEC E2 34 8和 EHEC O15 7)是婴幼儿腹泻、出血性结肠炎和尿路感染综合征 (尿毒症 )的主要病原菌 ,它们同属于粘附脱落 (Attaching/ Effacing,A/ E)大肠杆菌群 ,具有许多共同的毒力基因 ,定位于致病岛 L EE(the locus of enterocyte effacement)上。本试验主要就 A/ E大肠杆菌致病岛 L EE的 2个主要调节基因 lux和 ler基因对细菌致病性和免疫原性的影响进行了研究。所使用的始发菌株为兔致病性大肠杆菌 RDEC- 1,根据同源重组的原理 ,利用自杀性载体 p CVD44 2技术 ,敲除了位于染色体上的 lux和 ler基因 ,构建了 lux和 ler基因缺失突变株 ,研究了这 2个基因对细菌生长、毒力因子表达的调控作用以及基因缺失突变株的致病性和免疫保护作用。家兔实验研究表明 ,lux基因缺失突变株仍然残存着部分致病作用 ,不足以成为理想的致弱疫苗 ;而 ler基因缺失突变株安全性好 ,具有良好的免疫保护作用 ,是理想的家兔致弱疫苗候选株。这些研究资料为人 A/ E大肠杆菌疫苗 ,尤其是 EHEC O15 7疫苗的研制指明了方向 ,并提供了技术路线。 | 冯书章 Edgar C Boedeker Chengru Zhu Timothy Thate James Kaper 朱平 邓定华 | 2002 | 中国兽医学报2002，22，6： | 3 |
| 3 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 4 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 5 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 6 | Progress in structural materials for aerospace systems 显示文摘 | James C W Edgar A S | 2003 | Acta Materialia2003，51，： | 1 |
| 7 | Surface modification to improve dyeing of cotton fabric with a cationic dye显示文摘 | PISUNTORNSUG C YANUMET N EDGAR A O | 2002 | Coloration Technology2002，118，2： | 1 |
| 8 | Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Impli?cations for treatment and surgical management显示文摘 | EmamaulleeJ A Edgar R Toso C | 2010 | Liver Transpl2010，16，2： | 1 |
| 9 | Influence of dextran on the phase behavior of suspensions of cellulose nanocrystals显示文摘 | Edgar C D Gray D G | 2002 | Macromolecules2002，35，19： | 1 |
| 10 | Staudinger Reduction Chemistry of Cellulose: Synthesis of Selectively O-Acylated 6-Amino -6-deoxy-cellulose显示文摘 | Fox S C Edgar K J | 2012 | Biomacromolecules2012，13，4： | 1 |
| 11 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity 显示文摘 | Edgar R C | 2004 | BMC Bioinforma- tics2004，5，： | 1 |
| 12 | On the matrix cracking stress and the redistribution of internal stresses in brittle-matrix composites显示文摘 | EDGAR L C and CHRISTIANA M R | 1998 | Materials Science and Engineering1998，250，： | 1 |
| 13 | Critical care in Latin America current situation显示文摘 | Edgar C R | 2006 | Critical Care Clinics2006，22，： | 1 |
| 14 | MIMO fuzzy internal model control显示文摘 | C R Edgar B E Postlethwaite | 2000 | Automatica2000，36，6： | 1 |
| 15 | Cryopreservation of human ovarian tissue显示文摘 | Gook DA Edgar DH Stern C | 2004 | Eur J Obstet Gynecol Reprod Biol2004，1131，： | 1 |
| 16 | Advances in cellu- lose ester performance and application显示文摘 | Edgar K J Buchanan C M Debenham J S | 2001 | Prog Polym Sic2001，26，9： | 1 |
| 17 | Run-to-run control and performance monitoring of overlay in semiconductor manufacturing 显示文摘 | BODE C A KO B S EDGAR T F | 2004 | Control Engineering Practice2004，12，7： | 1 |
| 18 | MUSCLE:multiple sequence alignment with high accuracy and high throughput显示文摘 | EDGAR R C | | 0，，05： | 1 |
| 19 | Factors affecting the adoption of Internet Banking in Hong Kong-implications for the banking sector显示文摘 | Yiu C S Grant K Edgar D | 2007 | International Journal of Information Management2007，，5： | 1 |
| 20 | Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg显示文摘 | Wesnes KA Edgar C Tretter RN | 2009 | Expert Opin Drug Saf2009，8，6： | 1 |
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