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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | Characterization of conditions for the primary culture of human small intestinal epithelial cells显示文摘 | ALDHOUS M C SHMAKOV A N BODES J | 2001 | Clin Exp Immunol2001，125，1： | 1 |
| 3 | E 6 ]- Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase 显示文摘 | JEONG C H BODE A M PUGLIESE A | 2009 | Cancer Res2009，69，13： | 1 |
| 4 | Run-to-run control and performance monitoring of overlay in semiconductor manufacturing 显示文摘 | BODE C A KO B S EDGAR T F | 2004 | Control Engineering Practice2004，12，7： | 1 |
| 5 | Catheter ablation of electrical storm due to monomorphic ventricular tachycardia in patients with nonischemic cardiomyopathy:acute results and its effect on long-term survival显示文摘 | ARYA A BODE K PIORKOWSKI C | | 0，，12： | 1 |
| 6 | Characterization of conditions for the primary culture of human small intestinal epithelial cells显示文摘 | ALDHOUS M C SHMAKOV A N BODE J | 2001 | Clin Exp Immunol2001，125，1： | 1 |
| 7 | IgA against gut-derived endotoxins:does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease 显示文摘 | Parlesak A Schafer C Bode C | 2002 | Dig Dis Sci2002，47，4： | 1 |
| 8 | Characterization of conditions for the primary culture of human small intestinal epithelial cells 显示文摘 | Shmakov A N Bode J | 2001 | Clin Exp Immunol2001，125，1： | 1 |
| 9 | Transcriptional augmentation:modulation of gene expression by Scaffold/matrix-attached regions (S/MAR elements)显示文摘 | Bode J Benham C Knopp A | 2000 | Crit Rev Eukaryot Gene Expr2000，10，1： | 1 |
| 10 | Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial 显示文摘 | Seirica B M Morrow D A Bode C etal | 2010 | Eur Heart J2010，31，16： | 1 |
| 11 | Angiographic findings of the multicenter Randomized Study With the Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent (RAVEL): sirolimus-eluting stents inhibit restenosis irrespective of the vessel size显示文摘 | Regar E Serruys PW Bode C Holubarsch C Guermonprez JL Wijns W Bartorelli A Constantini C Degertekin M Tanabe K Disco C Wuelfert E Morice MC RAVEL Study Group | 2002 | Circulation2002，106，15： | 1 |
| 12 | Land-use proximity as a basis for assessing stream water quality in New York State (USA) 显示文摘 | Tran C P Bode R W Smith A J | 2010 | Ecological Indicators2010，10，3： | 1 |
| 13 | Long-Wavelength Global Gravity Models: GRIM4-S4,GRIM4-C4显示文摘 | SCHWINTZER P REIGBER C BODE A | 1997 | JGR1997，71，4： | 1 |
| 14 | Enhanced thrombolytic and antithrombotic potency of a fibrin-targeted plas- minogen activator in baboons 显示文摘 | Runge M S Harker L A Bode C | 1996 | Circulation1996，94，6： | 1 |
| 15 | Land-use Prox- imity as a Basis for Assessing Stream Water Quality in New York State(USA) 显示文摘 | Tran C P Bode R W Smith A J | 2010 | Ecological Indicators2010，10，： | 1 |
| 16 | 3D-simulation of dynamic interaction between track and layered sub- ground, system dynamics and long-term behaviour of railway vehicles 显示文摘 | Savidis S A Hirschauer R Bode C | 2003 | Track and Subgrade Lecture Notes in Applied Mechanics2003，6，： | 1 |
| 17 | Network analysis of protein dynamics 显示文摘 | Bode C Kovacs I A Szalay M S | 2007 | FEBS Lett2007，581，15： | 1 |
| 18 | Patent foramen ovale and cryptogenic stroke: a matter of age显示文摘 | Handke M Harloff A Bode C | 2009 | Semin Thromb He most2009，35，5： | 1 |
| 19 | Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial显示文摘 | Bode C Kern S Gries A | 2001 | The Lancet2001，357，9268： | 1 |
| 20 | The macrophage response towards LPS and its control through the p38MAPK-STAT3 axis显示文摘 | Bode JG Ehlting C H(a)ussinger D | | 0，，： | 1 |
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