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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 3 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 4 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 5 | 基于纸张各向异性光散射性能测量建立光学网点增大数学模型显示文摘0引言
印刷品反射光谱是多种因素综合作用的结果,包括油墨与纸张的光谱反射特性、纸张内部的光散射情况,以及印刷流程和加网方法等。印刷系统特性如印刷色域或光学网点增大(Optical Dot Gain,ODG)受上述因素的直接影响。为了精确控制印刷流程, | Kathrin Happel Marius Walter Philipp Urban Edgar Drsam 李人劼(编译) | 2012 | 中国印刷与包装研究2012，4，1： | 2 |
| 6 | Influence of dextran on the phase behavior of suspensions of cellulose nanocrystals显示文摘 | Edgar C D Gray D G | 2002 | Macromolecules2002，35，19： | 1 |
| 7 | Temperature dependence of Faraday rotation and magnetic susceptibility for Ce 3+ and Pr 3+ ions in fluorozirconate glass显示文摘 | A Edgar D Giltrap D.R MacFarlane | 1998 | Journal of Non-Crystalline Solids1998，，3： | 1 |
| 8 | Purification of a new neurotrophic factor from mammalian brain 显示文摘 | Barde YA Edgar D Thoenen H | 1982 | EMBO J1982，1，： | 1 |
| 9 | Implications of experimental petrology to the evolution of ultrapotassic rocks显示文摘 | Edgar A D and Vukadinovic D | 1992 | Lithos1992，28，： | 1 |
| 10 | Factors affecting the adoption of Internet Banking in Hong Kong-implications for the banking sector显示文摘 | Yiu C S Grant K Edgar D | 2007 | International Journal of Information Management2007，，5： | 1 |
| 11 | Spin-to-orbital angular momentum conversion in a strongly focused optical beam显示文摘 | ZHAO Y EDGAR J S JEFFRIES G D M | 2007 | Physical Review Letters2007，99，7： | 1 |
| 12 | Purification of a new neurotrophic factor from mammalian brain 显示文摘 | BRADE Y A EDGAR D THOENEN H | 1982 | EMBO J1982，1，5： | 1 |
| 13 | Partial melting of a phlogo- pite-clinopyroxenite nodule from south-west Uganda: An ex-perimental study bearing on the origin of highly potassic conti- nental rift volcanics显示文摘 | Lloyd F E Arima M Edgar A D | 1985 | Contributions to Mineralogy and Pe- trology1985，91，4： | 1 |
| 14 | Mapping Brain Activity During Loss of Situation Awareness : An EEG Investigation of A Basis for Top - down Influence on Perception 显示文摘 | Catherwood D Edgar GK Nikolla D | 2014 | Human Factors2014，56，8： | 1 |
| 15 | Purification of a new neurotrophic factor from mammalian brain显示文摘 | Barde YA Edgar D Thoenen H | 1982 | EMBO J1982，1，5： | 1 |
| 16 | Ethanol enhances the hemodynamic effects of felodipine 显示文摘 | BAILEY D G SPENCE J D EDGAR B | 1989 | Clin Invest Med1989，12，6： | 1 |
| 17 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreservation in 1,2-propanediol 显示文摘 | GOOK A EDGAR D H STERN C | 1999 | Hum Reprod1999，14，8： | 1 |
| 18 | A critical appraisal of cryopreservation (slow cooling versus vitrification) of human oocytes and embryos 显示文摘 | Edgar D H Gook D A | 2012 | Hum Reprod Update2012，18，： | 1 |
| 19 | Optimizing the use of detector arrays for measuring intensity correlations of photon pairs显示文摘 | Tasca D S Edgar M P Izdebski F | 2013 | Physical Review A2013，88，13： | 1 |
| 20 | Autoignition of dimethyl ether and dimerthoxy methame sprays at high pressures显示文摘 | Edgar B L Dibble R W Naegal D W | 1997 | SAE Transations Journal of Fuels and Lubricants1997，，1： | 1 |
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