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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Computer aided navigatin in neurosurgery显示文摘 | Grunert P Darabi N Espinosa J | 2003 | Neurosury Rev2003，26，3： | 1 |
| 3 | A phase Ⅱ trial of cisplatin and vinorelbine in patients with recurrent or metastatic squamous cell carcinoma of the head and neck显示文摘 | Espinosa E Zamora P Milla A | 2002 | Head Neck2002，24，12： | 1 |
| 4 | Nervous system proteoglycan as modulators of neurite outgrowth 显示文摘 | Bovolenta P Fernaud - Espinosa I | 2000 | Prog Neurobiol2000，61，2： | 1 |
| 5 | Identification of a gene,MLL,that spans the breakpoint in 11q23 translocations associated with human leukemias显示文摘 | Ziemin-Van Der Poel S McCabe NR Gill HJ Espinosa R 3rd Patel Y Harden A Rubinelli P Smith SD LeBeau MM Rowley JD | | 0，，： | 1 |
| 6 | Characterisation of dusts and sludges generated during stainless steel production in brazilian industries 显示文摘 | Nolasco-Sobrinho P J Espinosa D C R Tenorio J A S | 2003 | Iron- making and steelmaking2003，30，1： | 1 |
| 7 | Computer-aided navigation in neurosurgery 显示文摘 | Grunert P Darabi K Espinosa J | 2003 | Neurosurg Rev2003，26，2： | 1 |
| 8 | Age as an independent risk factor for severity of experimental choroidal neovascularization显示文摘 | Espinosa Heidmann D C Stmer I Hemandez E P | 2002 | Invest Ophthalmol Vis Sic2002，43，5： | 1 |
| 9 | Micromechanics of failure waves in glass:Ⅱ modeling显示文摘 | Espinosa H D Xu Y P | | 0，，08： | 1 |
| 10 | A model of optimal advertising expenditures in a dynamic duopoly显示文摘 | Espinosa MP Mariel P | 2001 | Atlantic Economic Journal2001，29，2： | 1 |
| 11 | Adventitious shoot regeneration and rooting of Prunus serotina in vitro vultures显示文摘 | ESPINOSA A C PIJUT P M MICHLER C H | 2006 | Hort Science2006，41，1： | 1 |
| 12 | Multiresidue analysis of anabolic compounds in bovine hair by gas chromatography-tandem mass spectrometry 显示文摘 | Marcos V Perogordo E Espinosa P | 2004 | Anal Chim Acta2004，507，： | 1 |
| 13 | Development and plas-ticity of the primary visual cortex显示文摘 | ESPINOSA J S STRYKER M P | | 0，，02： | 1 |
| 14 | Stereotactic biopsies guided by an optical navigation system: technique and clinical experience 显示文摘 | Grunert P Espinosa J Busert C | 2002 | Minim Invasive Neurosurg2002，45，1： | 1 |
| 15 | On speed control of induction motors 显示文摘 | Ortega R Nicklasson P J Espinosa G | 1996 | Automatic1996，32，3： | 1 |
| 16 | 查看详情显示文摘 | Duclos S J Jayaraman A Espinosa G P Cooper A S Maines G R | | 0，，： | 1 |
| 17 | Field and laboratoryselection of Frankliniella occidentalis (Pergande) for resistance to insecticides显示文摘 | Espinosa P J Bielza P Contreras J | 2002 | Pest Management Science2002，58，9： | 1 |
| 18 | The 19-kDa antigen of Mycobacterium tuberculosis is a major adhesion that binds the mannose receptor of THP 1 monocytic cells and promotes phagocytosis of mycobacteria 显示文摘 | Diaz H Espinosa P Sanchez GA | 2005 | Microbiol Pathog2005，9，3： | 1 |
| 19 | A phase Ⅱ trial of cisplatin and vinorelbine in patients with recurrent or metastatic squamous cell carcinoma of the head and neck显示文摘 | Espinosa E Zamora P Milla A | 2002 | Head Neck2002，24，12： | 1 |
| 20 | VP7 mediates the interaction of rotaviruses with integrinav133 through a novel integrin-binding site 显示文摘 | Zarate S Romero P Espinosa R | 2004 | J Virol2004，78，10： | 1 |
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