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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Characterisation of dusts and sludges generated during stainless steel production in brazilian industries 显示文摘 | Nolasco-Sobrinho P J Espinosa D C R Tenorio J A S | 2003 | Iron- making and steelmaking2003，30，1： | 1 |
| 3 | An overview on the current processes for the recycling of batte - ries 显示文摘 | Espinosa D C R Bemardes A M Teno6rio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 4 | Thermal behavior of chro- mium electroplating sludge显示文摘 | ESPINOSA D C R TEN RIO J A S | 2001 | Waste Management2001，21，4： | 1 |
| 5 | Alternative Nuclear Functions forNF-Kappab Family Members显示文摘 | ESPINOSA L BIGAS A MULERO M C | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 6 | Thermal behavior of chromi-um electroplating sludge显示文摘 | ESPINOSA D C R TEN6RI0 J A S | 2001 | Waste Manage2001，21，4： | 1 |
| 7 | Adventitious shoot regeneration and rooting of Prunus serotina in vitro vultures显示文摘 | ESPINOSA A C PIJUT P M MICHLER C H | 2006 | Hort Science2006，41，1： | 1 |
| 8 | An overview on the current processes for the recycling of batteries显示文摘 | Espinosa D C R Bernardes A M Tenorio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 9 | Transverse myelitis affect- ing more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients 显示文摘 | Espinosa G Mendizabal A Minguez S Ramo - Tello C Capellades J Olive A Cervera R | 2010 | Semin Arthritis Rheum2010，39，4： | 1 |
| 10 | WO3 films modified with functionalised multi-wall carbon nanotubes: Morphological, compositional and gas response studies显示文摘 | Bittencourt C Felten A Espinosa E H | 2006 | Sensors and Actuators B2006，115，1： | 1 |
| 11 | Increased Sodium-calcium Exchange Current in Right Ventricular Cell Hypertrophy Induced by Simulated High Altitude in Adult Rats显示文摘 | Espinosa L Chouabe C Morales A | 2000 | J Mol Cell Cardiol2000，32，4： | 1 |
| 12 | Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water显示文摘 | Espinosa A C Mazari-Hiriart M Espinosa R MaruriAvidal L Méndez E Arias C F | 2008 | Water Res2008，42，1011： | 1 |
| 13 | Field performance of temporary immersion bioreactor-erived sugarcane plants显示文摘 | LORENZO J C OJEDA E ESPINOSA A | 2001 | In vitro Cell Dev Boil-Plant2001，，37： | 1 |
| 14 | The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger显示文摘 | Tercero J A Espinosa J C Lacalle R A | 1996 | Journal of Biological Chemistry1996，271，3： | 1 |
| 15 | Effects of starch and protein source, heat processing and exogenous enzymes in starter diets for early weaned rabbits 显示文摘 | Gutierrez I Espinosa A Garcia J Caraba?o R De Blas J C | 2002 | Animal Feed Science and Thechnology2002，98，： | 1 |
| 16 | Materials science and fabrication processes for a new MEMS technoloey based on ultrananocrystalline diamond thin films 显示文摘 | AUCIELLO O BIRRELL J CARLISLE J A GERBI J E XIAO X C PENG B ESPINOSA H D | 2004 | Journal of Physics-Condensed Matter2004，16，： | 1 |
| 17 | Expression of the Streptomyces alboniger pur cluster in Streptomyces lividans is dependent on the bldA-encoded tRNA^Leu显示文摘 | Tercero J A Espinosa J C Jimenez A | 1998 | FEBS Lett1998，421，3： | 1 |
| 18 | Structural study of undoped and (Mn, In)-doped SnO2 thin films grown by RF sputtering 显示文摘 | Espinosa A Menendez N Prieto C | 2008 | J Non-Crystalline Solids2008，354，： | 1 |
| 19 | Field performance of temporary immersion bioreactor-derived sugarcane plants显示文摘 | LORENZO J C OJEDA E ESPINOSA A | 2001 | In Vitro Cell Dev Boil: Plant2001，37，： | 1 |
| 20 | The Pur10 protein encoded in the gene cluster for puromycin biosynthesis of Streptomyces alboniger is an NAD-dependent ATP dehydrogenase显示文摘 | Rubio M A Espinosa J C Tercero J A | 1998 | FEBS Letters1998，437，3： | 1 |
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