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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | MRI features of mucosa-associated lymphoid tissue lymphoma in the breast显示文摘 | ESPINOSA L A DANIEL B L JEFFREY S S | | 0，，01： | 1 |
| 3 | Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis显示文摘 | Villar J Perez-Mendez L Espinosa E | 2009 | PLoS One2009，4，8： | 1 |
| 4 | MLVA geno- typing of human Brucella isolates from Peru显示文摘 | Stairs H L Espinosa B Castillo R | 2009 | Trans R Soc Trop Med Hyg2009，103，4： | 1 |
| 5 | Alternative Nuclear Functions forNF-Kappab Family Members显示文摘 | ESPINOSA L BIGAS A MULERO M C | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 6 | Effect of alkaline pretreat- ment on anaerobic digestion of solid wastes 显示文摘 | L6pez T M Espinosa L M C | 2008 | Waste Manage2008，28，11： | 1 |
| 7 | A computer model for teaching the dynamic behavior of AC contac- tors显示文摘 | RUIZ J R ESPINOSA A G ROMERAL L | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 8 | Impaired mitogenic response of peripheral blood T cell in ulcerative colitis is not due to apoptosis显示文摘 | PEREZ-MACHADO M A ESPINOSA L M de la MADRGAL E J | 1999 | Dig Dis Sci1999，44，5： | 1 |
| 9 | Mechanistic aspects of hydrogen production by partial oxidation of methanol over Cu/ZnO catalysts 显示文摘 | Espinosa L Lago R M Pena M A | 2003 | Topics in Catalysis2003，22，： | 1 |
| 10 | The fatty acids of diet affect the reproductive physiol- ogy in bovine female: a review显示文摘 | Ortega Perez R Espinoza Villavicencio J L Palacios Espinosa A | 2012 | Tropical and Subtropical Agroecosystems2012，15，1： | 1 |
| 11 | Friction and wearbehaviour of WC - Co - Cr3 C2 - VC cemented carbides obtainedfrom nanocrystalline mixtures显示文摘 | Espinosa L Bonache V Salvador M D | 2011 | Wear2011，272，： | 1 |
| 12 | Plant oils: the perfect renewahle resource for polymer science显示文摘 | ESPINOSA L M D MEIER M A R | 2011 | European Pol- ymer Journal2011，47，5： | 1 |
| 13 | Pharmacokinetics of an injectable long-acting parenteral formulation of doxycycline hyclate in pigs显示文摘 | Gutierrez L Ocampo L Espinosa F | 2014 | J Vet Pharmacol Ther2014，37，1： | 1 |
| 14 | Plant associated biofilms显示文摘 | Molina M A Ramos J L Espinosa Urgel M | 2003 | Rev Environ Sci Biotechnol2003，2，： | 1 |
| 15 | Modelling steel cor rosion damage in soil environment 显示文摘 | Alamilla J L Espinosa M Sosa E | 2009 | Corro Sci2009，，： | 1 |
| 16 | The Notch pathway in the developing hematopoietic system 显示文摘 | Bigas A Robert-Moreno A Espinosa L | 2010 | Int J Dev Biol2010，54，67： | 1 |
| 17 | Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis显示文摘 | Villar J Perez-Mendez L Espinosa E | 2009 | PLoS One2009，4，8： | 1 |
| 18 | Effect of levels of starch,fiber and lactose on digestion and growth performance of early-weaned rabbits显示文摘 | Gutierrez l Espinosa A Garcia J | 2002 | Journal of Animal Science2002，80，： | 1 |
| 19 | Modelling steel corrosion damage in soil environment 显示文摘 | Alamilla J L Espinosa - Medina M A Sosa E | 2009 | Corros Sci2009，51，11： | 1 |
| 20 | Increased Sodium-calcium Exchange Current in Right Ventricular Cell Hypertrophy Induced by Simulated High Altitude in Adult Rats显示文摘 | Espinosa L Chouabe C Morales A | 2000 | J Mol Cell Cardiol2000，32，4： | 1 |
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