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| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 2 | Predictors of re-hospitalization in patients with chronic heart failure显示文摘Heart failure (HF) is a chronic, progressive illness that is highly prevalent in the United States and worldwide. This morbid illness carries a very poor prognosis, and leads to frequent hospitalizations. Repeat hospitalization in HF is both largely burdensome to the patient and the healthcare system, as it is one of the most costly medical diagnoses among Medicare recipients. For years, investigators have strived to determine methods to reduce hospitalization rates of HF patients. Despite such efforts, recent reports indicate that rehospitalization rates remain persistently high, without any improvement over the past several years and thus, this topic clearly needs aggressive attention. We performed a key-word search of the literature for relevant citations. Published articles, limited to English abstracts indexed primarily in the PubMed database through the year 2011, were reviewed. This article discusses various clinical parameters, serum biomarkers, hemodynamic parameters, and psychosocial factors that have been reviewed in the literature as predictors of re-hospitalization of HF patients. With this information, ourhope is that the future holds better risk-stratification models that will allow providers to identify high-risk patients, and better customize effective interventions according to the needs of each individual HF patient. | Melody Zaya Anita Phan Ernst R Schwarz | 2012 | World Journal of Cardiology2012，4，2： | 5 |
| 3 | Vascular depression for radiology: A review of the construct,methodology,and diagnosis显示文摘Vascular depression(VD)as defined by magnetic resonance imaging(MRI)has been proposed as a unique subtype of late-life depression.The VD hypothesis posits that cerebrovascular disease,as characterized by the presence of MRIdefined white matter hyperintensities,contributes to and increases the risk for depression in older adults.VD is also accompanied by cognitive impairment and poor antidepressant treatment response.The VD diagnosis relies on MRI findings and yet this clinical entity is largely unfamiliar to neuroradiologists and is rarely,if ever,discussed in radiology journals.The primary purpose of this review is to introduce the MRI-defined VD construct to the neuroradiology community.Case reports are highlighted in order to illustrate the profile of VD in terms of radiological,clinical,and neuropsychological findings.A secondary purpose is to elucidate and elaborate on the measurement of cerebrovascular disease through visual rating scales and semi-and fully-automated volumetric methods.These methods are crucial for determining whether lesion burden or lesion severity is the dominant pathological contributor to VD.Additionally,these rating methods have implications for the growing field of computer assisted diagnosis.Since VD has been found to have a profile that is distinct from other types of late-life depression,neuroradiologists,in conjunction with psychiatrists and psychologists,should consider VD in diagnosis and treatment planning. | Sara N Rushia Al Amira Safa Shehab Jeffrey N Motter Dakota A Egglefield Sophie Schiff Joel R Sneed Ernst Garcon | 2020 | World Journal of Radiology2020，12，5： | 5 |
| 4 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
| 5 | Phone density of states and negative thermal expansion in ZrW2O8显示文摘 | ERNST G BROHOLM C KOWACH G R | 1998 | Nature1998，396，： | 2 |
| 6 | Radiotherapy-induced heart disease:a review of the literature显示文摘Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers.Due to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant death.This is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after radiotherapy.Preclinical studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart injury.Epidemiological findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously assumed.Recent preclinical studies have identified non-invasive methods for evaluation of RIHD.Furthermore,potential options preventing or at least attenuating RIHD have been developed.Ongoing research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side effects.Here,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in RIHD.Biological mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized. | Bingwen Zou Julius Philipp Schuster Kerun Niu Qianyi Huang Alexander Rühle Peter Ernst Huber | 2019 | Precision Clinical Medicine2019，2，4： | 2 |
| 7 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Heiko Braak Kelly Del Tredici Udo Rüb Rob A.I de Vos Ernst N.H Jansen Steur Eva Braak | 2002 | Neurobiology of Aging2002，，2： | 2 |
| 8 | An Approach to Automatic Display Layout Using Combinatorial Optimization Algorithms显示文摘 | P Luder R Ernst S Stille | 1995 | Software:Practice and Experience1995，25，11： | 2 |
| 9 | Application of a new 2D time-domain full-waveform inversion scheme to crosshole radar data显示文摘 | Jacques R Ernst Alan G Green Hansruedi Maurer | 2007 | Geophysics2007，72，5： | 1 |
| 10 | KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors显示文摘 | Ernst S I Hubbs A E Przygodzki R M | 1998 | Lab Invest1998，78，12： | 1 |
| 11 | Magnetic resonance imaging of cystic adnexal lesions during pregnancy 显示文摘 | Oto A Ernst R Jesse M K | 2008 | Curr Probl Diagn Radiol2008，37，4： | 1 |
| 12 | Imaging of nontraumatic hemorrhage of the adrenal gland显示文摘 | Kawashima A Sandler C M Ernst R D | 1999 | Radiographics1999，19，： | 1 |
| 13 | Differential activation of the c - Ki - ras - 2 proto - oucogene in human colorectal carcinoma 显示文摘 | Halatsch ME Hirsch - Ernst KI Weinel R J | 1998 | Anticancer Res1998，18，4： | 1 |
| 14 | Ultrsound - guided trans - bron- chial biopsy of solitary pulmonary nodules less than 20mm 显示文摘 | Eberhardt R Ernst A Herth FJ | 2009 | Eur Respir J2009，34，6： | 1 |
| 15 | Herbal medicines for the treatment of rhinosinusitis:a systematic review显示文摘 | Guo R Canter PH Ernst E | | 0，，： | 1 |
| 16 | Efficacy of endobronchial ultrasound-guided transbronehial needle aspiration of hilar lymph nodes for diagnosing and staging cancer 显示文摘 | Ernst A Eberhardt R Krasnik M | 2009 | J Thorac Oncol2009，4，8： | 1 |
| 17 | Hardware-software cosynthesis for microcontrollers显示文摘 | Ernst R Henkel J Benner T | 1993 | IEEE Design & Test of Computers1993，10，4： | 1 |
| 18 | Telomeres and telomerase : biological and clinical importance显示文摘 | Dahse R Fiedler W Ernst G | 1997 | Clin Chem1997，43，： | 1 |
| 19 | LFTs for automotive appli- cations显示文摘 | Henning F Ernst H Brussel R | 2005 | Reinforced plastics2005，49，2： | 1 |
| 20 | Relationship Between the National ED Overcrowding Scale and the Number of Patients Who Leave Without Being Seen in an Academic ED显示文摘 | Weiss S J Ernst A A Derlet R King R Bair A Nick T G | 2005 | Am J Emerg Med2005，23，3： | 1 |
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