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| 1 | Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions显示文摘AIM To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions(SPL). METHODS A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area(A) representing the region of interest and area(B) representing the normal area. Area(B) was then divided by area(A). Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated by comparing diagnoses made by elastography, strain ratio and final diagnoses.RESULTS SPL were shown to be benign in 49 patients and malignant in 123 patients. Elastography alone had a sensitivity of 99%, a specificity of 63%, and an accuracy of 88%, a PPV of 87% and an NPV of 96%. The best cut-off level of strain ratio to obtain the maximal area under the curve was 7.8 with a sensitivity of 92%, specificity of 77%, PPV of 91%, NPV of 80% and an accuracy of 88%. Another estimated cut off strain ratio level of 3.8 had a higher sensitivity of 99% and NPV of 96%, but with less specificity, PPV and accuracy 53%, 84% and 86%, respectively. Adding both elastography to strain ratio resulted in a sensitivity of 98%, specificity of 77%, PPV of 91%, NPV of 95% and accuracy of 92% for the diagnosis of SPL. CONCLUSION Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL. | Hussein Okasha Shaimaa Elkholy Ramy El-Sayed Mohamed-Naguib Wifi Mohamed El-Nady Walid El-Nabawi Waleed A El-Dayem Mohamed I Radwan Ali Farag Yahya El-sherif Emad Al-Gemeie Ahmed Salman Mohamed El-Sherbiny Ahmed El-Mazny Reem E Mahdy | 2017 | World Journal of Gastroenterology2017，23，32： | 11 |
| 2 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 3 | Synchronization and Control of Hyperchaotic Complex Lorenz System显示文摘 | GAMAL M M EMAD E M | 2010 | Mathematics and Computers in Simulation2010，80，12： | 1 |
| 4 | A new approach for pa-rameter estimation of finite Weibull mixture distributionsfor reliability modeling显示文摘 | EMAD E E ABDALLAH W A | 2013 | Applied Mathematical Mod-eling2013，37，4： | 1 |
| 5 | A modified shuffled frog-leaping optimization algorithm: Applications to project management显示文摘 | Emad E Tarek H Donald G | 2007 | Structure and Infrastructure Engineering2007，3，1： | 1 |
| 6 | Functional networks as a novel data mining paradigm in forecasting software development efforts显示文摘 | EMAD A E | 2010 | Expert Systems with Applications2010，，： | 1 |
| 7 | Advances in the Adomian decomposition method for solving two-point nonlinear boundary value prob- lems with Neumann boundary conditions显示文摘 | EMAD H ABDE E RAN R | 2012 | Compu Math Appl2012，63，6： | 1 |
| 8 | Comparison among five evolutionary-based optimization algorithms显示文摘 | EMAD E TAREK H DONALD G | 2005 | AdvancedEngineering Informatics2005，19，： | 1 |
| 9 | Improved image watermarking scheme using fast Hadamard and discrete wavelet transforms显示文摘 | Abdallah Emad E Ben Hamza A | 2007 | Journal of Electronic imaging2007，16，03： | 1 |
| 10 | Comparison among Five Evolutionary-based Optimization Algorithms 显示文摘 | EMAD E TAREK H DONALD G | 2005 | Advanced Engineering Informatics2005，19，： | 1 |
| 11 | Hash chain links resynchronization methods in video streaming security: performance comparison显示文摘 | EMAD A E MOHAMMED B HOSSAM A | 2011 | Journal of Mobile Multimedia2011，7，1： | 1 |
| 12 | Integrated visualized time control system for repetitive construction projects显示文摘 | Emad E Mahmoud D | 2011 | Automation in Construction2011，20，7： | 1 |
| 13 | Noninvasive estimation of tissue temperature response to heating field using diagnostic ultrasound 显示文摘 | RAIF S EMAD S E | 1995 | IEEE Transactions on Biomedical Engineering1995，42，8： | 1 |
| 14 | A modified shuffled frog-leaping opti- mization algorithm: applications to project management显示文摘 | Emad E Tarek H Donald G | 2007 | Structure and Infrastructure Engineering2007，3，1： | 1 |
| 15 | Comparison among five evolutionary-based optimization algorithms显示文摘 | TAREK H DONALD G | 2005 | Ad-vanced Engineering Informatics2005，19，1： | 1 |
| 16 | Advances in the Adomian decomposition method for solving two-point nonlinear boundary value problems with Neumann boundary conditions显示文摘 | EMAD H ALY ABDE E | 2012 | Compu Math Appl2012，63，6： | 1 |
| 17 | On the hyperchaotic complex Lti system 显示文摘 | Gamal M Mahmoud Emad E Mahmoud Mansour E | 2009 | Nonlinear Dynamics2009，24，8： | 1 |
| 18 | A modified shuffled frog-leaping optimization algorithm: Applications to project management 显示文摘 | Emad E Tarek H Donald G | 2007 | Structure and Infrastructure Engineering2007，3，1： | 1 |
| 19 | A newapproach for parameter,estimation of finite Weibullmixture distributions for reliability modeling显示文摘 | EMAD E ELMAHDY ABDALLAH W A | 2013 | AppliedMathematical Modeling2013，37，： | 1 |
| 20 | Comparison of two evolutionary algorithms for optimization of bridge deck repairs显示文摘 | Hatem E Emad E Tarek H Khaled S | 2006 | Computer-Aided Civil and Infrastructure Engineering2006，21，： | 1 |
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