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| 1 | In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging显示文摘Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical device.Unfortunately,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells(hMSC) and magnetic resonance imaging(MRI) compatibility of the potential material combination polyetheretherketone/titanium(PEEK/Ti) for medical devices.Because of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or cobalt-chrome.However,PEEK is a bioinert material having a limited ability for direct bone incorporation.Due to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular response.The result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of titanium.The appearance of metal-related artifact was discussed in electrical resistivity and magnetic susceptibility.Therefore,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface conductivity.To determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral deposition.The cellular stress was evaluated by the prostaglandin E_2 level.The bonded materials both produced no disturbing artifacts in magnetic resonance imaging.Compared to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibility,which is indicated by a higher cell number,larger activity of the enzyme tissue non-specific alkaline phosphatase and therefore a greater amount of deposited calcium and phosphate.The results on bare PEEK are accompanied with a higher cellular stress level,which is indicated by prostaglandin E_2. | Cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause Ulrich Scheler Ute Hempel | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 2 | Star-shaped oligothiophenes for solution-processible organic fieldeffect transistors显示文摘 | PONOMARENKO S A KIRCHMEYER S ELSCHNER A | 2003 | Adv Funct Mater2003，13，8： | 1 |
| 3 | Work function independent hole-injection barriers between pentacene and conducting polymers显示文摘 | Koch N Elschner A Rabe J P | | 0，，22： | 1 |
| 4 | Nested reverse transeriptase polymerase chain reaction for the detec- tion of group A rotavirus显示文摘 | Elschner M PrudloJ Hotzel H | 2002 | J Vet Med2002，49，： | 1 |
| 5 | Detection of Brucella melitensis in bovine milk and milk products from apparently healthy animals in Egypt by real-time PCR显示文摘 | Wareth G Melzer F Elschner MC | 2014 | J Infect Dev Ctries2014，8，10： | 1 |
| 6 | A discrete collocation method for Symm's integral equation on curves with corners显示文摘 | ELSCHNER J STEPHAN E P | 1996 | Comput Appl Math1996，75，： | 1 |
| 7 | Gallium complexes in threelayer organic electroluminescent devices 显示文摘 | Elschner A Heuer H W Jonas F | 2001 | Adv Mater2001，13，23： | 1 |
| 8 | Manufacture and testing of MCP2212 Bifilar coils for a 10MVA fault current limiter 显示文摘 | Elschner S Bruer F Noe M | 2006 | IEEE Transactions on Applied Superconductivity2006，13，： | 1 |
| 9 | Manufacture and testing of MCP2212 Bifilar coils for a 10MVA fault current limiter显示文摘 | Elschner S Bruer F Noe M | 2006 | IEEE Transactions on Applied Superconductivity2006，13，2： | 1 |
| 10 | What the design of an R~D tax incentive tells about its effectiveness:a simulation of R~D tax incentives in the European Union显示文摘 | ELSCHNER CHRISTINA | 2011 | The Jour- nal of Technology Transfer2011，36，3： | 1 |
| 11 | 显示文摘 | PONOMARENKO S A KIRCHMEYE R S ELSCHNER A | 2003 | Adv Funct Mater2003，13，： | 1 |
| 12 | Detection of rotaviruses and intestinal lesions in broiler chicks from flocks with runting and stunting syndrome (RSS) 显示文摘 | Otto P Liebler-Tenorio E M Elschner M | 2006 | Avian Dis2006，50，： | 1 |
| 13 | Uniqueness in determining polygonal sound-hard obstacles with a single incoming wave显示文摘 | Elschner J Yamamoto M | 2006 | Inverse Problems2006，22，1： | 1 |
| 14 | ENSYSTROB – Design, manufacturing and test of a 3-phase resistive fault current limiter based on coated conductors for medium voltage application显示文摘 | S. Elschner A. Kudymow J. Brand S. Fink W. Goldacker F. Grilli M. Noe M. Vojenciak A. Hobl M. Bludau C. J?nke S. Kr?mer J. Bock | 2012 | Physica C: Superconductivity and its applications2012，，： | 1 |
| 15 | First commercial medium voltage superconducting fault-current limiters: production, testand installation显示文摘 | R Dommerque S Kr?mer A Hobl R B?hm M Bludau J Bock D Klaus H Piereder A Wilson T Krüger G Pfeiffer K Pfeiffer S Elschner | 2010 | Superconductor Science and Technology2010，，3： | 1 |
| 16 | Hole injection from an ITO/PEDOT anode into the hole transport layer of an OLED probed by bias induced absorption 显示文摘 | K Book H Bassler A Elschner | 2003 | Organic Electronics(S1566-1199)2003，4，： | 1 |
| 17 | Nested reverse transcriptase polymerase chain reac tion for the detection of group A rotavirus显示文摘 | ELSCHNER M PRUDLO J HOTZEL H | 2002 | J Vet Med2002，49，： | 1 |
| 18 | Single-layer electroluminescence device made with novle copolymers containing electronand hole-transporting moieties显示文摘 | Tian H Zhu W H Elschner A | 2000 | Synth Met2000，，： | 1 |
| 19 | Manufacturing and testing of MCP2212 bifdar coils for 10 MVA fault current limiter显示文摘 | Elschner S Breuer F Noe M | 2003 | IEEE Transactions on Applied Superconductivity2003，13，2： | 1 |
| 20 | Inverse Scattering for Periodic Structures : Stability of Polygonal Interfaces 显示文摘 | Elschner J Schmidt G | 2001 | Inverse Probl2001，17，6： | 1 |
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