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| 1 | 低频电刺激治疗脑卒中偏瘫患者的临床研究进展显示文摘 | 郭友华 燕铁斌 Christina WY Hui-Chan | 2005 | 中华物理医学与康复杂志2005，27，8： | 35 |
| 2 | Two stages of immiscible liquid separation in the formation of Panzhihua-type Fe-Ti-V oxide deposits,SW China显示文摘在 260 妈 Emeishan 大火的省(ELIP ) 的 Magmatic 氧化物沉积物, SW 中国和北越南,是 Fe, Ti 和 V 的重要来源。一些巨大的 magmatic Fe-Ti-V 氧化物沉积物例如 Panzhihua, Hongge,和 Baima 沉积物,很好在文学被描述并且在 Panxi 区域在分层的 mafic-ultramafic 侵入被招待,中央 ELIP。ELIP 相关的沉积物的一样的类型也远发生到南方并且在红河差错地区包括 Anyi 沉积物, Panzhihua 的大约 130 km 南方,和 Mianhuadi 沉积物。Anyi 沉积物是相对小的,但是同样在分层的 mafic 侵入被招待。Mianhuadi 沉积物有 260 妈的锆石 U-Pb 年龄并且与 ELIP 因此是同时期的。这存款易变地在指责的 Indosinian 造山运动和红河期间被变形。组合地, Mianhuadi 存款的磁铁矿比另外的存款的包含 Ti 和 V 的更小的数量,对以后的变态可能可归因。氧化物矿石存款的分发不与 ELIP 的 domal 结构有关。在 ELIP 的所有氧化物存款的一个主要特征是忍受氧化物的 gabbroic 侵入,黑花岗石 plutons 和 high-Ti 洪水暗岩的空间协会。因此,我们建议从一根披风羽毛的岩浆是进他们被发展进液体 immiscibility 的域形成二硅酸盐液体的一个浅岩浆房间的 emplaced,与一极其 Fe-Ti-rich gabbroic 作文和另外的黑花岗石。不能混合的 Fe-Ti-(P) 氧化物融化然后可以与 mafic 岩浆分开形成氧化物存款。这些存款从形成了的父母岩浆是在作文的可能的 Fe-Ti-rich picritic 并且比生产了 ELIP 的忍受硫化物的侵入的岩浆在更大的深度从充实的 asthenospheric 披风被导出。 | Mei-Fu Zhou Wei Terry Chen Christina Yan Wang Stephen A.Prevec Patricia Pingping Liu Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 35 |
| 3 | 功能性电刺激改善脑卒中早期患者偏瘫下肢功能的随机对照研究显示文摘目的:探讨功能性电刺激(FES)对脑卒中偏瘫患者下肢功能的影响。方法:37例脑卒中早期患者分层后随机分为FES组(19例,年龄60.8±10.8岁,病程25.9±21.3d)和对照组(18例,年龄64.1±9.7岁,病程22.7±16.6d)。2组常规治疗相同,对照组不给予任何电刺激,FES组采用日本生产的低频电刺激治疗仪(KR7型)治疗,电极放在患侧胫前肌及腓骨长、短肌的运动点上;刺激参数为频率30Hz,脉宽200μs,通电/断电比5s/5s,波升/波降(1s/1s),电流以患者最大耐受强度为限。治疗每天1次,每次30min,共3周(15次)。用综合痉挛量表(CSS)评定踝关节痉挛,Fugl-Meyer运动评定量表中下肢部分(FMA)评定下肢运动功能,脑卒中患者姿势评定量表(PASS)和Berg平衡量表(BBS)评定平衡功能。结果:2组患者一般资料及治疗前各项评定结果差异无显著性意义。治疗2周和3周后,FES组与对照组(FESvs对照)CSS、FMA评分差异有显著性意义(P<0.05),增加率为2周时CSS:8.9%±23.2%vs36.3%±47.3%,FMA:105.5%±75.7%vs51.4%±47.3%。3周时CSS:10.4%±18.3%vs47.7%±56.4%,FMA:127.1%±89.4%vs64.3%±51.8%。结论:FES能延缓早期脑卒中患者偏瘫下肢痉挛的发生、减轻痉挛程度,改善下肢运动能力。 | 游国清 燕铁斌 Christina WY HUI-CHAN | 2007 | 中国康复医学杂志2007，22，10： | 31 |
| 4 | 低频电刺激治疗脑卒中偏瘫的神经机制研究进展显示文摘 | 郭友华 燕铁斌 Christina WY Hui-Chan | 2005 | 中国康复医学杂志2005，20，2： | 27 |
| 5 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 6 | 组织工程化人工神经修复长段神经缺损实验的初步报告显示文摘目的 研究组织工程化人工神经修复大鼠 2 .5cm长坐骨神经缺损的效果。方法 90只 2个月月龄的Lewis 1W雌性大鼠 ,按手术先后顺序随机分成 3个神经移植组 ,每组 3 0只。A组 :用种植同源雪旺细胞并具有内部支架结构的胶原神经管桥接 ,即组织工程化人工神经组。B组 :用无雪旺细胞但具有内部支架结构的胶原神经管桥接 ,即对照组。C组 :自体神经移植组。术后 6个月 ,进行神经电生理监测 ,神经肌肉组织学观察 ;用S 10 0和神经微丝蛋白免疫组化染色后 ,行轴突计数等检测。结果 完成对 2 1只大鼠 (每组 7只 )的实验评估。从A组和C组的胫前肌中均能诱发出波幅明显的神经肌肉复合动作电位 (CMAP) ,再生轴突已通过移植段神经全长 ,远端肌肉轻度萎缩。B组中则没有或仅记录到波幅很低的CMAP ,移植神经远端结缔纤维组织增生 ,再生轴突罕见 ,所支配肌肉明显萎缩。结论 组织工程化人工神经可用来修复大鼠长段神经缺损。 | 沈尊理 Berger Alfred Hierner Robert Lohmeyer Joern Allmeling Christina Walter F.Gerhard | 2001 | 中华手外科杂志2001，17，2： | 22 |
| 7 | Wolf运动功能测试量表的标准效度和评定者内部信度研究显示文摘目的:研究脑卒中偏瘫患者上肢运动的Wolf运动功能测试量表(WMFT)的标准效度和评定者内部信度研究。方法:22例脑卒中慢性期患者在2周内由同一测试者进行WMFT的检查,并与Fugl-Meyer评价量表上肢部分进行效度分析。结果:两次WMFT计时组内相关系数(ICC)为0.990,95%置信区间为0.977—0.996;两次WMFT动作质量分级组内相关系数(ICC)为0.988,95%置信区间为0.970—0.995。WMFT计时与WMFT动作质量分级相关系数为-0.971(P<0.001),WMFT计时与FMA上肢评分相关系数为-0.732(P<0.001),WMFT动作质量分级与FMA评分相关系数为0.838(P<0.001)。结论:WMFT具有好的重测信度和标准效度。 | 毕胜 Christina Hui-Chan | 2006 | 中国康复医学杂志2006，21，12： | 21 |
| 8 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 9 | JOB BURNOUT显示文摘 | Christina Maslach Wilmar B. Schaufeli Michael P. Leiter | 2001 | Annual Review of Psychology2001，，： | 20 |
| 10 | Split liver transplantation: Current developments显示文摘In 1988, Rudolf Pichlmayr pioneered split liver transplantation(SLT), enabling the transplantation of one donor liver into two recipients-one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. However, a SLT is technically demanding, may cause increased perioperative complications, and may potentially transform an excellent deceased donor organ into two marginal quality grafts. Thus, crucial evaluation of donor organs suitable for splitting and careful screening of potential SLT recipients is warranted. Furthermore, the logistic background of the splitting procedure as well as the organ allocation policy must be adapted to further increase the number and the safety of SLT. Under defined circumstances, in selected patients and at experienced transplant centers, SLT outcomes can be similar to those obtained in full organ LT. Thus, SLT is an important tool to reduce the donor organ shortage and waitlist mortality, especially for pediatric patients and small adults. The present review gives an overview of technical aspects, current developments, and clinical outcomes of SLT. | Christina Hackl Katharina M Schmidt Caner Süsal Bernd Dohler Martin Zidek Hans J Schlitt | 2018 | World Journal of Gastroenterology2018，24，47： | 20 |
| 11 | Characterization and functions of beta defensins in the epididymis显示文摘附睾β - defensins 由重复基因复制和分叉演变编码对病原体提供直接保护并且也在它的主要功能支持男繁殖的道的蛋白质的一个家庭。男道 defensins 也从病原体攻击便于恢复。β - defensins 拥有古老的保存顺序和在多细胞的有机体普遍的结构的特征,在种幸存建议基本角色。首领 SPAG11,二祖先地独立的β - defensin 基因的功能的熔化,生产根据 tissue-specificand 被表示的或者拼接的抄本的一个大家庭种类特定的限制。SPAG11 的复杂性在哺乳动物的进化的不同分支变化。有主人蛋白质的人的 SPAG11D 的相互作用在多重发信号的小径显示参与。 | Susan H. Hall Suresh Yenugu Yashwanth Radhakrishnan Maria Christina W. Avellar Peter Petrusz Frank S. French | 2007 | Asian Journal of Andrology2007，9，4： | 18 |
| 12 | 虚拟国际规范文档——连接德国国家图书馆和美国国会图书馆的规范文档显示文摘德国国家图书馆、美国国会图书馆和OCLC联机计算机图书馆中心联合开发了一个个人名称的虚拟国际规范文档(VIAF),它连接世界各国国家书目机构的规范记录,并免费提供网上检索,以证明自动连接不同国家规范文档的规范记录的可行性和优点。美国国会图书馆和德国国家图书馆的规范文档和书目文档被用来创建初始的VIAF,其中包括600多万个名称和50多万个连接。该项目的一个关键点是利用规范记录和其对应书目记录的信息开发自动名称匹配算法。该项目显示了用算法建立不同国家规范文档的个人名称之间连接的实用性。VIAF项目的长远目标是将许多国家图书馆和其他重要来源的规范名称结合起来,形成一个共享的全球规范服务。参考文献3。 | Rick Bennett Christina Hengel-Dittrich Edward T.O’Neill Barbara B.Tillett 顾犇 | 2006 | 国家图书馆学刊2006，15，4： | 15 |
| 13 | New technologies to investigate the brain-gut axis显示文摘Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology. Knowledge of how the brain processes sensory information from visceral structures is still in its infancy. However, our understanding has been propelled by technological imaging advances such as functional Magnetic Resonance Imaging, Positron Emission To-mography, Magnetoencephalography, and Electroen-cephalography (EEG). Numerous human studies have non-invasively demonstrated the complexity involved in functional pain processing, and highlighted a number of subcortical and cortical regions involved. This review will focus on the neurophysiological pathways (primary afferents, spinal and supraspinal transmission), brain- imaging techniques and the influence of endogenous and psychological processes in healthy controls and patients suffering from functional gastrointestinal dis- orders. Special attention will be paid to the newer EEG source analysis techniques. Understanding the pheno- typic differences that determine an individual's response to injurious stimuli could be the key to understanding why some patients develop pain and hyperalgesia in response to inflammation/injury while others do not. For future studies, an integrated approach is required incorporating an individual's psychological, autonomic, neuroendocrine, neurophysiological, and genetic prof ile to def ine phenotypic traits that may be at greater risk of developing sensitised states in response to gut in? am- mation or injury. | Abhishek Sharma Dina Lelic Christina Brock Peter Paine Qasim Aziz | 2009 | World Journal of Gastroenterology2009，15，2： | 15 |
| 14 | Volatile and C-H-O isotopic compositions of giant Fe-Ti-V oxide deposits in the Panxi region and their implications for the sources of volatiles and the origin of Fe-Ti oxide ores显示文摘The Panzhihua,Hongge,and Baima Fe-Ti-V oxide deposits in the Panzhihua-Xichang(Panxi) region are hosted in large layered mafic-ultramafic intrusions.The layered intrusions intrude either the Neoproterozoic Dengying Formation,composed mainly of limestone,or the Paleoproterozoic Hekou Formation,composed of meta-sedimentary-volcanic rocks.It remains unclear if the wall rocks have been involved during the fractionation of magmas and have affected the sequence of crystallization of Fe-Ti oxide.Volatiles and their C-H-O isotopic compositions of magnetite,apatite,clinopyroxene,and plagioclase of different types of ores from the three intrusions are analyzed using a technique of stepwise heating mass spectrometer to evaluate the role of wall rocks in the formation of Fe-Ti oxide ores.Volatiles released from magnetite are composed mainly of H 2 O and CO 2,whereas the other minerals are composed mainly of H 2 O,CO 2 and H 2.At 800-1200°C temperature interval,the average 13 C values of CO 2 of all the minerals from the three intrusions range from 7.7‰ to 13.5‰ and the average 18 O CO 2 values from 19.1‰ to 19.5‰,which are scattered in a mixed field with basalt and the two types of wall rocks as end-members,indicating that CO 2 from the wall rocks may have been involved in the magmas from which the three intrusions formed.At 400-800 C temperature interval,both 13 C values(13.7‰ to 17.9‰ on the average) and 18 O values(16.2‰ to 19.2‰ on the average) of CO 2 of all the minerals are lower than those for 800-1200 C temperature interval,and much closer to the values of the wall rocks.Abundant H 2 O released at the 400-800 C temperature interval has relatively low D values ranging from 90‰ to 115‰,also indicating the involvement of fluids from the wall rocks.The average bulk contents of volatiles released from magnetite of the Hongge,Baima,and Panzhihua intrusions are 4891,2996,and 1568 mm 3 STP/g,respectively,much higher than those released from other minerals in total,which are 382,600,and 379 mm 3 STP/g,respectively,indicating that magnetite crystallized from magmas with much more volatiles than other minerals.This can be interpreted as that crystallization of clinopyroxene and plagioclase in the early fractionation of magmas resulted in volatiles such as H 2 O that were eventually enriched in the residual magmas and,at the same time,fluids from the wall rocks may have been involved in the magmas and were trapped in magnetite,which crystallized later than clinopyroxene and plagioclase. | WANG Christina Yan | 2012 | Science China Earth Sciences2012，55，11： | 15 |
| 15 | 低频电刺激改善早期脑卒中偏瘫患者日常生活活动能力的随机对照研究显示文摘目的 探讨低频电刺激(LES)对脑卒中偏瘫患者日常生活活动(ADL)能力的影响.方法 37例早期脑卒中患者经minimize软件分层后随机分为电刺激组19例和对照组18例.2组常规治疗相同,对照组不行电刺激治疗,电刺激组采用LES治疗,电极置于偏瘫侧胫前肌及腓骨长、短肌的运动点上,刺激参数为频率30 Hz,脉宽200μs,通电/断电比5 s/5s,波升/波降为1s/1s,电流以患者最大耐受强度为限.每天治疗1次,每次30 min,共3周(15次).用Fugl-Meyer运动功能评定量表(FMA)中下肢部分评定下肢运动功能,用改良Barthel指数(MBI)评定ADL能力.结果 2组患者一般资料及治疗前各项评定结果差异无统计学意义(P〉0.05).治疗2周和3周后,电刺激组与对照组的FMA评分及MBI总分比较,差异均有统计学意义(P〈0.05),电刺激组与对照组在MBI各项中的床椅转移、平地行走及上下楼梯等评分比较,差异有统计学意义(P〈0.05).结论 LES能提高早期脑卒中偏瘫患者下肢运动能力及ADL能力. | 游国清 燕铁斌 Christina WY Hui-Chan | 2010 | 中华物理医学与康复杂志2010，32，9： | 13 |
| 16 | Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment显示文摘Spondyloarthropathies(SpA) include many different forms of inflammatory arthritis and can affect the spine(axial SpA) and/or peripheral joints(peripheral SpA) with Ankylosing spondylitis(AS) being the prototype of the former. Extraarticular manifestations, like uveitis, psoriasis and inflammatory bowel disease(IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria. Bowel involvement seems to be the most common of these manifestations. Clinically evident IBD is observed in 6%-14% of AS patients, which is significantly more frequent compared to the general population. Besides, it seems that silent microscopic gut inflammation, is evident in around 60% in AS patients. Interestingly, occurrence of IBD has been associated with AS disease activity. For peripheral SpA, two different forms have been proposed with diverse characteristics. Of note, SpA(axial or peripheral) is more commonly observed in Crohn's disease than in ulcerative colitis. The common pathogenetic mechanisms that explain the link between IBD and SpA are still ill-defined. The role of dysregulated microbiome along with migration of T lymphocytes and other cells from gut to the joint('gut-joint' axis) has been recognized, in the context of a genetic background including associations with alleles inside or outside the human leukocyte antigen system. Various therapeutic modalities are available with monoclonal antibodies against tumour necrosis factor, interleukin-23 and interleukin-17, being the most effective. Both gastroenterologists and rheumatologists should be alert to identify the coexistence of these conditions and ideally follow-up these patients in combined clinics. | George E Fragoulis Christina Liava Dimitrios Daoussis Euangelos Akriviadis Alexandros Garyfallos Theodoros Dimitroulas | 2019 | World Journal of Gastroenterology2019，25，18： | 13 |
| 17 | Role of the receptor for advanced glycation end products in hepatic fibrosis显示文摘AIM:To study the role of advanced glycation end products(AGE)and their specifi c receptor(RAGE)in the pathogenesis of liver fi brogenesis.METHODS:In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells(HSC)were measured after stimulation with the two RAGE ligands,advanced glycation end product-bovine serum albumin(AGE-BSA)and Nε-(carboxymethyl)lysine(CML)-BSA,or with tumor necrosis factor-α(TNF-α).In vivo RAGE expression was examined in models of hepatic fi brosis induced by bile duct ligation or thioacetamide.The effects of AGE-BSA and CML-BSA on HSC proliferation,signal transduction and profi brogenic gene expression were studied in vitro.RESULTS:In hepatic fibrosis,RAGE expression was enhanced in activated HSC,and also in endothelial cells,inflammatory cells and activated bile duct epithelia.HSC expressed RAGE which was upregulated after stimulation with AGE-BSA,CML-BSA,and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation,apoptosis,fibrogenic signal transduction and fibrosis-or fibrolysis-related gene expression,except for marginal upregulation of procollagen α1(Ⅰ)mRNA by AGE-BSA.CONCLUSION:Despite upregulation of RAGE in activated HSC,RAGE stimulation by AGE does not alter their fibrogenic activation.Therefore,RAGE does not contribute directly to hepatic fibrogenesis. | Christina Lohwasser Daniel Neureiter Yury Popov Michael Bauer Detlef Schuppan | 2009 | World Journal of Gastroenterology2009，15，46： | 13 |
| 18 | Current developments in pediatric liver transplantation显示文摘In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attempt an orthotopic liver transplant into a 3 years old patient suffering from biliary atresia. Thus, the first LT in humans was attempted in a disease, which, up until today, remains the main indication for pediatric LT(p LT). During the last sixty years, refinements in diagnostics and surgical technique, the introduction of new immunosuppressive medications and improvements in perioperative pediatric care have established LT as routine procedure for childhood acute and chronic liver failure as well as inherited liver diseases. In contrast to adult recipients, p LT differs greatly in indications for LT, allocation practice, surgical technique, immunosuppression and postoperative life-long aftercare. Many aspects are focus of ongoing preclinical and clinical research. The present review gives an overview of current developments and the clinical outcome of p LT, with a focus on alternatives to full-size deceased-donor organ transplantation. | Christina Hackl Hans J Schlitt Martin Loss Birgit Knoppke Michael Melter | 2015 | World Journal of Hepatology2015，7，11： | 13 |
| 19 | 负面事件对旅游目的地的影响及应对策略--基于动态视角的实验研究显示文摘近年来,负面事件层出不穷,在网络媒体的推波助澜下,旅游目的地遭遇严重的形象危机。辨识负面事件类型,洞悉负面事件影响机制及动态变化,采取适配性应对策略,是化解旅游目的地负面事件危机的关键。文章基于信任理论和情境危机沟通理论,通过3个情境实验,从动态视角考察负面事件对旅游目的地的影响及应对策略。研究结果表明:旅游目的地负面事件包括能力型负面事件和道德型负面事件。其中,能力型负面事件通过能力信任降低旅游目的地评价,道德型负面事件通过善意信任降低旅游目的地评价。并且,相对于能力型负面事件,道德型负面事件的负面影响更大。能力型负面事件发生后,旅游目的地评价随着时间的推移缓慢回升,而道德型负面事件发生后,旅游目的地评价持续处于低位。根据负面事件的影响趋势,对于能力型负面事件,旅游目的地商家在事件发生第2天正面应对效果最佳;对于道德型负面事件,旅游目的地政府在事件发生第2天正面应对效果最佳。文章引入时间维度,为负面事件的影响及应对策略研究提供了新的视角,为旅游目的地危机处理提供了切实有效的措施。 | 胡家镜 万秋 刘悦 Christina G.CHI | 2020 | 旅游学刊2020，35，5： | 12 |
| 20 | Big Earth Data science:an information framework for a sustainable planet显示文摘The digital transformation of our society coupled with the increasing exploitation of natural resources makes sustainability challenges more complex and dynamic than ever before.These changes will unlikely stop or even decelerate in the near future.There is an urgent need for a new scientific approach and an advanced form of evidence-based decisionmaking towards the benefit of society,the economy,and the environment.To understand the impacts and interrelationships between humans as a society and natural Earth system processes,we propose a new engineering discipline,Big Earth Data science.This science is called to provide the methodologies and tools to generate knowledge from diverse,numerous,and complex data sources necessary to ensure a sustainable human society essential for the preservation of planet Earth.Big Earth Data science aims at utilizing data from Earth observation and social sensing and develop theories for understanding the mechanisms of how such a social-physical system operates and evolves.The manuscript introduces the universe of discourse characterizing this new science,its foundational paradigms and methodologies,and a possible technological framework to be implemented by applying an ecosystem approach.CASEarth and GEOSS are presented as examples of international implementation attempts.Conclusions discuss important challenges and collaboration opportunities. | Huadong Guo Stefano Nativi Dong Liang Max Craglia Lizhe Wang Sven Schade Christina Corban Guojin He Martino Pesaresi Jianhui Li Zeeshan Shirazi Jie Liu Alessandro Annoni | 2020 | International Journal of Digital Earth2020，13，7： | 12 |
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