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| 1 | Vanishing bone disease(Gorham-Stout syndrome): A review of a rare entity显示文摘Vanishing bone disease(Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by de struction of osseous matrix and proliferation of vascula structures, resulting in destruction and absorption o bone. Despite the extensive investigation of the patho genetic mechanisms of the disease, its etiology hasn'been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, includ ing the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffer ing from vanishing bone disease includes, pain, func tional impairment and swelling of the affected region although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture. In this short review we summarize the theories regarding the etiology as well as the clini cal presentation, the diagnostic approach and treat ment options of this rare disease. | Vasileios S Nikolaou Dimitrios Chytas Demitrios Korres Nicolas Efstathopoulos | 2014 | World Journal of Orthopedics2014，5，5： | 13 |
| 2 | Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection显示文摘AIM:To detect of colorectal cancer(CRC) circulating tumour cells(CTCs) surface antigens,we present an assay incorporating cadmium selenide quantum dots(QDs) in these paper.METHODS:The principle of the assay is the immunomagnetic separation of CTCs from body fluids in conjunction with QDs,using specific antibody biomarkers:epithelial cell adhesion molecule antibody,and monoclonal cytokeratin 19 antibody.The detection signal was acquired from the fluorescence signal of QDs.For the evaluation of the performance,the method under study was used to isolate the human colon adenocarcinoma cell line(DLD-1) and CTCs from CRC patients' peripheral blood.RESULTS:The minimum detection limit of the assay was defined to 10 DLD-1 CRC cells/mL as fluorescence was measured with a spectrofluorometer.Fluorescenceactivated cell sorting analysis and Real Time RT-PCR,they both have also been used to evaluate the performance of the described method.In conclusion,we developed a simple,sensitive,efficient and of lower cost(than the existing ones) method for the detection of CRC CTCs in human samples.We have accomplished these results by using magnetic bead isolation and subsequent QD fluorescence detection.CONCLUSION:The method described here can be easily adjusted for any other protein target of either the CTC or the host. | Maria Gazouli Anna Lyberopoulou Pericles Pericleous Spyros Rizos Gerassimos Aravantinos Nikolaos Nikiteas Nicholas P Anagnou Efstathios P Efstathopoulos | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 3 | Importance of establishing radiation protection culture in Radiology Department显示文摘The increased use of ionization radiation for diagnostic and therapeutic purposes, the rapid advances in computed tomography as well as the high radiation doses delivered by interventional procedures have raised serious safety and health concerns for both patients and medical staff and have necessitated the establishment of a radiation protection culture(RPC) in every Radiology Department. RPC is a newly introduced concept. The term culture describes the combination of attitudes, beliefs, practices and rules among the professionals, staff and patients regarding to radiation protection. Most of the time, the challenge is to improve rather than to build a RPC. The establishment of a RPC requires continuing education of the staff and professional, effective communication among stakeholders of all levels and implementation of quality assurance programs. The RPC creation is being driven from the highest level. Leadership, professionals and associate societies are recognized to play a vital role in the embedding and promotion of RPC in a Medical Unit. The establishment of a RPC enables the reduction of the radiation dose, enhances radiation risk awareness, minimizes unsafe practices, and improves the quality of a radiation protection program. The purpose of this review paper is to describe the role and highlight the importance of establishing a strong RPC in Radiology Departments with an emphasis on promoting RPC in the Interventional Radiology environment. | Agapi Ploussi Efstathios P Efstathopoulos | 2016 | World Journal of Radiology2016，8，2： | 4 |
| 4 | Cemented Müller straight stem total hip replacement:18 year survival,clinical and radiological outcomes显示文摘AIM: To present the 18 year survival and the clinical and radiological outcomes of the Müller straight stem, cemented, total hip arthroplasty(THA).METHODS: Between 1989 and 2007, 176 primary total hip arthroplasties in 164 consecutive patients were performed in our institution by the senior author. All patients received a Müller cemented straight stem and a cemented polyethylene liner. The mean age of the patients was 62 years(45-78). The diagnosis was primary osteoarthritis in 151 hips, dysplasia of the hip in 12 and subcapital fracture of the femur in 13. Following discharge, serial follow-up consisted of clinical evaluation based on the Harris Hip Score and radiological assessment. The survival of the prosthesis using revision for any reason as an end-point was calculated by KaplanMeier analysis.RESULTS: Twenty-four(15%) patients died during the follow-up study, 6(4%) patients were lost, while the remaining 134 patients(141 hips) were followedup for a mean of 10 years(3-18 years). HSS score at the latest follow-up revealed that 84 hips(59.5%) had excellent results, 30(22.2%) good, 11(7.8%) fair and 9(6.3%) poor. There were 3 acetabular revisions due to aseptic loosening. Six(4.2%) stems were diagnosed as having radiographic definitive loosening; however, only 1 was revised. 30% of the surviving stems showed no radiological changes of radiolucency, while 70% showed some changes. Survival of the prosthesis for any reason was 96% at 10 years and 81% at 18 years. CONCLUSION: The 18 year survival of the Müller straight stem, cemented THA is comparable to those of other successful cemented systems. | Vasileios S Nikolaou Demetrios Korres Stergios Lallos Andreas Mavrogenis Ioannis Lazarettos Ioannis Sourlas Nicolas Efstathopoulos | 2013 | World Journal of Orthopedics2013，4，4： | 4 |
| 5 | Early weight bearing after posterior malleolar fractures: An experimental and prospective clinical study显示文摘 | George Papachristou Nicolas Efstathopoulos Constantin Levidiotis Efstathios Chronopoulos | 2003 | The Journal of Foot and Ankle Surgery2003，，2： | 2 |
| 6 | Intramedullary fixation of intertrochanteric hip fractures: a comparison of two implant designs显示文摘 | Efstathopoulos NS Nikolaos VS Lazarettos JT | 2007 | Int Orthop2007，31，1： | 1 |
| 7 | Intramed- ullary fixation of interochanteric hip fractures a comparison of two implant designs显示文摘 | Efstathopoulos NE Nikolaou VS Lazarettos JT | 2007 | Int Orthop2007，31，1： | 1 |
| 8 | Intramedullary fixation of intertrochanteric hip fractures:a comparison of two implant designs显示文摘 | Efstathopoulos NE Nikolaou VS Lazarettos JT | 2007 | Int Orthop2007，31，1： | 1 |
| 9 | Minimally invasive plate osteosynthesis - an update 显示文摘 | Nikolaou VS Efstathopoulos N Papakostidis C | 2008 | Curr Orthop2008，22，3： | 1 |
| 10 | Intramedullary fixa- tion of intertrochanteric hip fractures: a comparison of two implant designs 显示文摘 | Efstathopoulos NE Nikolaou VS Lazarettos Jr | 2007 | Int Orthop2007，1，： | 1 |
| 11 | The influence of osteoporosis in femoral fracture healing time 显示文摘 | Nikolaou V S Efstathopoulos N Kontakis G | 2009 | Injury2009，40，6： | 1 |
| 12 | Hamstring tendons regeneration after ACL reconstruction: an overview显示文摘 | Vassilios S. Nikolaou Nicolas Efstathopoulos Torsten Wredmark | 2007 | Knee Surgery Sports Traumatology Arthroscopy2007，，2： | 1 |
| 13 | Hamstring tendons regeneration after ACL reconstruction:an overview显示文摘 | NIKOLAOU V S EFSTATHOPOULOS N WREDMARKT | | 0，，02： | 1 |
| 14 | Early weight bearing after posterior malleolar fi'actures: an experimental and pro- spective clinical study显示文摘 | Papaehristou G Efstathopoulos N Levidiotis C | 2003 | J Foot Ankle Surg2003，42，2： | 1 |
| 15 | Vortex formation and recirculation zones in left anterior descending artery stenoses: computational fluid dynamics analysis显示文摘 | D G Katritsis A Theodorakakos I Pantos A Andriotis E P Efstathopoulos G Siontis N Karcanias S Redwood M Gavaises | 2010 | Physics in Medicine and Biology2010，，5： | 1 |
| 16 | The influence of osteoporosis in femoral fracture healing time显示文摘 | Nikolaou VS Efstathopoulos N Kontakis G | | 0，，06： | 1 |
| 17 | IntrameduUary fixa- tion of intertrochanteric hip fractures : a comparison of two implan- ted-signs 显示文摘 | Efstathopoulos NE Nikolaou VS Lazarettos Jr | 2007 | Int Orthop2007，68，1： | 1 |
| 18 | Intramesullary fixation of intertrochan- teric hip fractures a comparison of two implant designs 显示文摘 | EFSTATHOPOULOS N E NIKOLAOU V S LAZA- REYYOS J T | 2007 | Int Orthop2007，1，： | 1 |
| 19 | Intramedullary fixation of intertrochanteric hip fractures : a comparison of two implant designs 显示文摘 | Efstathopoulos NE Nikolaou VS Lazarettos JT | 2007 | Int Orthop2007，1，： | 1 |
| 20 | Early weight beating after posterior malleolar fractures: an experimental and prospective clinical study 显示文摘 | Papachristou G Efstathopoulos N Levidiotis C | 2003 | J Foot Ankle Surg2003，2，： | 1 |
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