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| 1 | Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke显示文摘Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their functions.The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these treatments.Memantine is an approved drug for the treatment of Alzheimer's disease.Memantine is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate receptor.Memantine has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical trials.The present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients. | Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 2 | Gas-phase electrocatalytic conversion of CO_2 to chemicals on sputtered Cu and Cu–C catalysts electrodes显示文摘A novel gas-phase electrocatalytic cell containing a low-temperature proton exchange membrane(PEM)was developed to electrochemically convert CO_2into organic compounds.Two different Cu-based cathode catalysts(Cu and Cu–C)were prepared by physical vapor deposition method(sputtering)and subsequently employed for the gas-phase electroreduction of CO_2at different temperatures(70–90°C).The prepared electrodes Cu and Cu–C were characterized by X-ray diffraction(XRD),X-ray photoemission spectroscopy(XPS)and scanning electron microscopy(SEM).As revealed,Cu is partially oxidized on the surface of the samples and the Cu and Cu–C cathodic catalysts were comprised of a porous,continuous,and homogeneous film with nanocrystalline Cu with a grain size of 16 and 8 nm,respectively.The influence of the applied current and temperature on the electro-catalytic activity and selectivity of these materials was investigated.Among the two investigated electrodes,the pure Cu catalyst film showed the highest CO_2specific electrocatalytic reduction rates and higher selectivity to methanol formation compared to the Cu–C electrode,which was attributed to the higher particle size of the former and lower Cu O/Cu ratio.The obtained results show potential interest for the possible use of electrical renewable energy for the transformation of CO_2into valuable products using low metal loading Cu based electrodes(0.5 mg Cu cm^(-2))prepared by sputtering. | N.Gutiérrez-Guerra J.A.González J.C.Serrano-Ruiz E.López-Fernández J.L.Valverde A.de Lucas-Consuegra | 2019 | Journal of Energy Chemistry2019，28，4： | 3 |
| 3 | Effect of PCB 126 and PCB 153 on incidence of apoptosis in cultured theca and granulosa cells collected from small, medium and large preovulatory follicles显示文摘 | E.L Gregoraszczuk M Sowa M Kajta A Ptak A Wójtowicz | 2003 | Reproductive Toxicology2003，，4： | 2 |
| 4 | Urban resurgence and the consumer city显示文摘 | Glaeser E.L Gottlieb D | | 0，，08： | 1 |
| 5 | Levels of analysis and the organization of affect显示文摘 | Rosenberg E.L | | 0，，： | 1 |
| 6 | Self-determination Theory and the Facilitation intrinsic motivation,social development,and well-being显示文摘 | Ryan R.M Deci E.L | | 0，，55： | 1 |
| 7 | Geology and fluid characteristics of the Mina Velha and Mandiocal orebodies and implications for the genesis of the orogenic Chega Tudo gold deposit,Gurupi Belt,Brazil显示文摘 | Klein E.L Ribeiro J.W.A Harris C Moura C.A.V Giret A | | 0，，： | 1 |
| 8 | Changes in the Value-Relevance of Earnings and Book Values over the Past Forty Years显示文摘 | Collins D.W Maydew E.l Weiss I.S | | 0，，01： | 1 |
| 9 | Self-determination theory:A macrotheory of human motivation,development and health显示文摘 | Deci E.L Ryan R.M | | 0，，： | 1 |
| 10 | Social network and health-related quality of life in older adults:A population-based study in Spain显示文摘 | E.L(O)PEZ.GARCA J.R.BANEGAS A.GRACIANI | | 0，，02： | 1 |
| 11 | The measurement of general self-efficacy:A study of construct validity显示文摘 | Tipton R.M Worthington E.L | | 0，，05： | 1 |
| 12 | Partnering:Contracting for the Future显示文摘 | Cook E.L Hancher D.E | | 0，，6： | 1 |
| 13 | Processes of cave breakdown显示文摘 | White E.L White W.B | | 0，，： | 1 |
| 14 | Phase changes in metal combustion显示文摘 | E.L Dreizin | | 0，，01： | 1 |
| 15 | A survey of postoperative nausea and vomiting显示文摘 | M.Koivuranta E.L??r? L.Sn?re S.Alahuhta | 2004 | Anaesthesia2004，，5： | 1 |
| 16 | Self-determination theory and work motivation显示文摘 | Gagne M Deci E.L | | 0，，： | 1 |
| 17 | From ego depletion to vitality:Theory and findings concerning the facilitation of energy available to the self显示文摘 | Ryan R.M Deci E.L | | 0，，02： | 1 |
| 18 | Application of the testing and spacing effects to name learning显示文摘 | Carpenter S.K Delosh E.L | | 0，，05： | 1 |
| 19 | Selling to the newsvendor:an analysis of price-only contracts显示文摘 | Lariviere M.A Porteus E.L | | 0，，04： | 1 |
| 20 | Impoverished cue support enhances subsequent retention:Support for the elaborative retrieval explanation of the testing effect显示文摘 | Carpenter S.K Delosh E.L | | 0，，02： | 1 |
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