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| 1 | 肠易激综合征中下丘脑-垂体-肠腺轴调节失调:血浆细胞因子是否为潜在的生物标记显示文摘Background & Aims: Irritable bowel syndrome (IBS) is a functional disorder with an etiology that has been linked to both psychological stress and infection. The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles. Methods: A total of 151 subjects, 76 patients and 75 controls, were recruited. The patients with IBS were diagnosed according to Rome II criteria. Forty-nine patients and 48 matched controls had cytokine levels measured, and a subset of 21 patients and 21 controls also underwent a corticotropin-releasing hormone (CRH) stimulation test with plasma levels of adrenocorticotropic hormone (ACTH) and cortisol measured. The remaining 27 patients and 27 controls underwent a dexamethasone (1 mg) challenge. Results: Cortisol and the proinflammatory cytokines interleukin (IL)- 6 (together with its soluble receptor) and IL-8 were elevated in all IBS subgroups (diarrhea predominant, constipated, and alternators), although the elevation was most marked in the constipated subgroup. There was no alteration in the anti-inflammatory cytokine IL- 10. Following CRH infusion, an exaggerated release of both ACTH and cortisol was observed in patients with IBS. There was a significant correlation between the ACTH response (δ ACTH) and the IL- 6 levels. A similar relationship existed between the δ ACTH/δ cortisol ratio and the IL- 6 levels. Dexamethasone suppression of cortisol was similar in patients and controls. Conclusions: IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammat ory cytokine increase. | Dinan T.G. Quigley E.M.M. Ahmed S.M.M. 赵天智 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 3 |
| 2 | Investigation of the effect of ZrO 2 and ZrO 2 /Al 2 O 3 additions on the hot-pressing and properties of equimolecular mixtures of α- and β-Si 3 N 4显示文摘 | E.M.M. Ewais M.A.A. Attia A. Abousree-Hegazy R.K. Bordia | 2010 | Ceramics International2010，，： | 1 |
| 3 | The synthesis of carbon coated Fe, Co and Ni nanoparticles and an examination of their magnetic properties显示文摘 | A.A. El-Gendy E.M.M. Ibrahim V.O. Khavrus Y. Krupskaya S. Hampel A. Leonhardt B. Büchner R. Klingeler | 2009 | Carbon2009，，12： | 1 |
| 4 | Microwave-induced combustion of crude oil for further rare earth elements determination by USN–ICP-MS显示文摘 | J.S.F. Pereira L.S.F. Pereira P.A. Mello R.C.L. Guimar?es R.A. Guarnieri T.C.O. Fonseca E.M.M. Flores | 2014 | Analytica Chimica Acta2014，，： | 1 |
| 5 | DELAYS AT SIGNALIZED INTERSECTIONS WITH EXHAUSTIVE TRAFFIC CONTROL *显示文摘 | M.A.A. Boon I.J.B.F. Adan E.M.M. Winands D.G. Down | 2012 | Probability in the Engineering and Informational Sciences2012，，3： | 1 |
| 6 | Corrosion mechanisms in aqueous solutions containing dissolved H 2 S. Part 1: Characterisation of H 2 S reduction on a 316L rotating disc electrode显示文摘 | J. Kittel F. Ropital F. Grosjean E.M.M. Sutter B. Tribollet | 2013 | Corrosion Science2013，，： | 1 |
| 7 | 云贵鄂渝水土保持世行贷款/欧盟赠款项目区碳储量估测显示文摘以云贵鄂渝水土保持世行贷款/欧盟赠款项目实施过程中不同水土保持林、封山育林、经济林及梯田土壤碳储量、地上生物量、地下生物量为研究对象,建立了333个样地并进行了实地调查,根据调查数据,建立了地上部分生物量与地下生物量回归方程,在此基础上,计算出林地碳储量与大气CO2削减量。结果表明,各类植被土壤中碳储量均较低。随着树木年龄的增长,林分同化能力的增强,大气CO2的削减量也会随之增大;项目实施后生态效益明显。 | 徐姣 杨佳 陈志禄 黎东鑫 张子言 陈明亮 邹庆琳 赖信舟 E.M.M.阿雷兹 张卓文 | 2012 | 水利水电快报2012，33，1： | 0 |
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