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| 1 | Autochthonous halotolerant plant growth-promoting rhizobacteria promote bacoside A yield of Bacopa monnieri(L.)Nash and phytoextraction of salt-affected soil显示文摘Phytoremediation is a promising approach for reclamation of salt-affected soil.Phytoextraction is the most commonly used process,which exploits plants to absorb,immobilize,and accumulate salt in their shoots.In this study,halotolerant plant growth-promoting rhizobacteria(PGPR)were isolated from the rhizosphere of wild grasses growing naturally in salt-affected areas of Lucknow,Uttar Pradesh(India)and were tested for their efficacies of salt-tolerance and plant growth-promoting(PGP)abilities.Based on 16S rRNA sequences,the most efficient halotolerant isolates possessing PGP traits were identified as Pseudomonas plecoglossicida(KM 233646),Acinetobacter calcoaceticus(KM 233647),Bacillus flexus(KM 233648),and Bacillus safensis(KM 233652).Application of these isolates as bio-inoculants significantly(P<0.05)increased the growth and bacoside A yield of a medicinal plant,Bacopa monnieri(L.)Nash,grown on natural salt-affected soil.The phytoremediation of salt-affected soil was evident by the substantial increase in shoot Na^+:K^+ratio of bio-inoculant-treated plants.When compared to un-inoculated control plants,the soil physico-chemical properties of bio-inoculant-treated plants were improved.The shoot and root biomass(fresh and dry weights),soil enzymes,and soil nutrient parameters showed significant positive correlations with the shoot Na+:K+ratio.Consequently,the halotolerant PGPR screened in this study could be useful for the reclamation of saline soils concomitant with improved plant growth and bacoside A yield. | Umesh PANKAJ Durgesh Narain SINGH Pooja MISHRA Pooja GAUR C.S.Vivek BABU Karuna SHANKER Rajesh Kumar VERMA | 2020 | Pedosphere2020，30，5： | 9 |
| 2 | Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase- mediated cell death显示文摘 | Subhadip MUKHOPADHYAY Prashanta Kumar PANDA Durgesh Nandini DAS Niharika SINHA Birendra BEHERA Tapas Kumar MAITI Sujit Kumar BHUTIA | 2014 | Acta Pharmacologica Sinica2014，35，6： | 5 |
| 3 | Organo-Petrographic and Pore Facets of Permian Shale Beds of Jharia Basin with Implications to Shale Gas Reservoir显示文摘The shale deposits of Damodar Valley have received great attention since preliminary studies indicate their potential for shale gas. However, fundamental information allied to shale gas reservoir characteristics are still rare in India, as exploration is in the primary stage. In this study, Barakar shale beds of eastern part of Jharia Basin are evaluated for gas reservoir characteristics. It is evident that Barakar shales are carbonaceous, silty, contains sub-angular flecks of quartz and mica, irregular hair-line fractures and showing lithological variations along the bedding planes, signifying terrestrial-fluviatile deposits under reducing environment. The values of TOC varies from 1.21 wt.% to 17.32 wt.%, indicating good source rock potentiality. The vitrinite, liptinite, inertinite and mineral matter ranging from 0.28 vol.% to 12.98 vol.%, 0.17 vol.% to 3.23 vol.%, 0.23 vol.% to 9.05 vol.%, and 74.74 vol.% to 99.10 vol.%, respectively. The ternary facies plot of maceral composition substantiated that Barakar shales are vitrinite rich and placed in the thermal-dry gas prone region. The low values of the surface area determined following different methods point towards low methane storage capacity, this is because of diagenesis and alterations of potash feldspar responsible for pore blocking effect. The pore size distribution signifying the micro to mesoporous nature, while Type II sorption curve with the H2 type of hysteresis pattern, specifies the heterogeneity in pore structure mainly combined-slit and bottle neck pores. | Vinod Atmaram Mendhe Subhashree Mishra Ranjit G.Khangar Alka Damodhar Kamble Durgesh Kumar Atul Kumar Varma H.Singh Sujeet Kumar Mollika Bannerjee | 2017 | Journal of Earth Science2017，28，5： | 1 |
| 4 | recurrent lower motor neuron type facial pals an unsual manifestation of SLE显示文摘 | Durgesh Kumar Gupta Virendra Atam S C Chaudhry | 2011 | BMJ Case Rep2011，22，01： | 1 |
| 5 | Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer显示文摘 | Niharika Sinha Subhadip Mukhopadhyay Durgesh Nandini Das Prashanta Kumar Panda Sujit K. Bhutia | 2013 | Oral Oncology2013，，： | 1 |
| 6 | Methyl-salicylate:A surveillance system fortriggering immunity in neighboring plants显示文摘Plant behavioral actions have been one of the major topicsof research in plant biology and agriculture.These actionsfrom plants are determined by their instant structural andphysical reactions to the circumstances(Bouwmeester et al.,2019).Upon sensing abiotic factors such as salinity,flooding,high temperature,drought,plants make suitable changes intheir physiology and behavior to survive such harsh conditions. | Saumya Jaiswal Durgesh Kumar Tripathi Ravi Gupta JingHe Zhong-Hua Chen Vijay Pratap Singh | 2024 | Journal of Integrative Plant Biology2024，66，2： | 0 |
| 7 | Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis显示文摘The liver injury leads to an inflammatory response, which causes the activation of hepatic stellate cells (HSCs) that further secrete ECM proteins and play an important role in liver fibrosis. Moreover, the inflammatory response is a driving force for fibrogenesis, which is triggered by many types of injuries. Exaggerated inflammatory immune responses are mediated by cytoplasmic protein complexes known as inflammasomes, which are involved in many chronic liver diseases. Inflammasomes are pattern recognition receptors (PRRs) that can sense any microbial motifs known as pathogen-associated molecular patterns (PAMPs), and host- or environmental-derived stress signals known as damage-associated molecular patterns (DAMPs). The inflammasomes cause caspase-mediated proteolytic cleavage of pro-IL-1β and pro-IL-18 into active IL-1β and IL-18. In this review, we provide a comprehensive summary of the important roles of NLRP3 inflammasome in the pathogenesis of liver fibrosis with an emphasis on several direct and indirect pathways responsible for the NLRP3 inflammasome-mediated HSCs activation and fibrogenesis. In addition, we discuss the general pharmacological and genetics strategies for the inhibition of NLRP3 inflammasome activation and its downstream signaling with examples of emerging pharmacotherapeutics, targeting the NLRP3 inflammasome signaling as well as a possible way to develop effective and safer NLRP3 inflammasome inhibitors. | Harsh Vardhan Charan Durgesh Kumar Dwivedi Sabbir Khan Gopabandhu Jena | 2023 | Genes & Diseases2023，10，2： | 0 |
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