|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Highly efficient and precise base editing in discarded human tripronuclear embryos显示文摘 | Guanglei Li Yajing Liu Yanting Zeng Jianan Li Lijie Wang Guang Yang Dunjin Chen Xiaoyun Shang Jia Chen Xingxu Huang Jianqiao Liu | 2017 | Protein & Cell2017，8，10： | 8 |
| 2 | Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes:A Randomized,Placebo-controlled,Calcium Supplementation Trial显示文摘Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF,Ff,and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups:one received calcium tablet (600 mg once daily as CaCO 3) and the other placebo tablet once daily for 1 year.At baseline,BMD was measured by dual‐energy X‐ray absorptiometry at lumbar spine (L2‐L4) and at left hip whereas serum PICP,serum OC,and urinary CTX,serum 25(OH)VitD 3,and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention,BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05,<0.01,and <0.001,respectively).BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05).Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype. | YU Bo WU HongYing LI Fang GONG Jie ZHOU DunJin ZHANG ZhiFeng YANG XiaoGuang HUANG ZhenWu | 2011 | Biomedical and Environmental Sciences2011，24，3： | 6 |
| 3 | Intra-abdominal aortic balloon occlusion in the management of placenta percreta显示文摘Background:Massive bleeding is the main concern for the management of placenta percreta(PP).Intra-abdominal aortic balloon occlusion(IABO)is one method for pelvic devascularization,but the efficacy of IABO is uncertain.This study aims to investigate the outcomes of IABO in PP patients.Methods:We retrospectively reviewed the clinical data of PP cases from six tertiary centers in China between January 2011 and December 2015.PP cases with/without the use of IABO were analyzed.Propensity score matching analysis was performed to reduce the effect of selection bias.Postpartum hemorrhage(PPH)and the rate of hysterectomy,as well as neonatal outcomes,were analyzed.Results:One hundred and thirty-two matched pairs of patients were included in the final analysis.Compared with the control group,maternal outcomes,including PPH(68.9%vs.87.9%,χ^(2)=13.984,P<0.001),hysterectomy(8.3%vs.65.2%,χ^(2)=91.672,P<0.001),and repeated surgery(1.5%vs.12.1%,χ^(2)=11.686,P=0.001)were significantly reduced in the IABO group.For neonatal outcomes,Apgar scores at 1 minute(8.67±1.79vs.8.53±1.68,t=-0.638,P=0.947)and 5 minutes(9.43±1.55vs.9.53±1.26,t=0.566,P=0.293)were not significantly different between the two groups.Conclusions:IABO can significantly reduce blood loss,hysterectomies,and repeated surgeries.This procedure has not shown harmful effects on neonatal outcomes. | Weiran Zheng Ruochong Dou Jie Yan Xinrui Yang Xianlan Zhao Dunjin Chen Yuyan Ma Weishe Zhang Yiling Ding Ling Fan Huixia Yang | 2022 | Chinese Medical Journal2022，，4： | 2 |
| 4 | Maternal and perinatal outcome in cases of fulminant viral hepatitis in late pregnancy显示文摘 | Liuzhi Deng Xiaomao Li Zhongjie Shi Peiru Jiang Dunjin Chen Lin Ma | 2012 | International Journal of Gynecology and Obstetrics2012，，2： | 1 |
| 5 | Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue显示文摘Background:High salt-diets have become significant threats to human health,resulting in hypertension and cardiovascular diseases.Hypertensive disorders during pregnancy are complicated,since the maternal cardiovascular system undergoes extensive physiological changes during pregnancy.High-salt diets during pregnancy can disturb the intrauterine environment and negatively affect fetal development.Therefore,we explored how high-salt diets during pregnancy could affect the offspring.Methods:Rats were divided into three groups and fed with low,normal,and high salt diets.The offspring were separated into three groups after weaning based on dietary salt concentration.The blood pressure and urine protein content of both dams and offspring were measured.To evaluate cardiac function,we used Masson staining and immunodetection to confirm the fibrosis status.Finally,we extracted protein from cardiac tissue to test the expression levels of the Nitric Oxide(NO)/cGMP-dependent protein kinase I(PKGI)pathway and the angiotensin receptor.Results:High-salt diets increased blood pressure,and offspring previously exposed to high-salt environments were predisposed to hypertension.High-salt diets were also found to induce cardiac fibrosis and exacerbate fibrosis in offspring and alter the epithelial-mesenchymal transition(EMT).Under these conditions,the NO/PKGI pathway was activated in cardiac tissue and the type-1angiotensin II receptor(AT1R)was upregulated,though the type-2 angiotensin II receptor(AT2R)had the opposite effect.Conclusion:High-salt diets induce high blood pressure and increase predisposition to hypertension in offspring.They are accompanied by cardiac fibrosis,which could be caused by the activation of NO/PKGI and upregulation of AT1R. | Minshan Huang Xiuying Li Luwen Ren Lin Huang Jiahong Pan Jinlin Yao Lili Du Dunjin Chen Jingsi Chen | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，2： | 1 |
| 6 | A new, large tyrannosaurine theropod from the Upper Cretaceous of China显示文摘 | David W.E. Hone Kebai Wang Corwin Sullivan Xijin Zhao Shuqing Chen Dunjin Li Shuan Ji Qiang Ji Xing Xu | 2011 | Cretaceous Research2011，，4： | 1 |
| 7 | Association of an Increased Risk of Pre-eclampsia and Fetal Growth Restriction in Singleton and Twin Pregnancies with Female Fetuses显示文摘Objective: To investigate whether the fetal gender affects the incidence of pre-eclampsia (PE) and fetal growth restriction (FGR) in singleton and twin pregnancies.Methods: This was a 10-year single-center, retrospective, cohort study from January 2009 to January 2019. A total of 57,129 singleton and 3699 twin pregnancies aged between 18-55 years old were recruited at the Third Affiliated Hospital of Guangzhou Medical University, China. We used multivariable logistic regression to analyze the effect of fetal gender on the incidence of PE and FGR.Results: In singleton pregnancies, the incidence rates of PE and FGR with a female fetus were higher than those with a male fetus (6.4% (1713/26,793)vs. 5.9% (1803/30,336),P < 0.05 and 3.5% (932/26,793)vs. 2.4% (745/30,336),P < 0.05, respectively). A female fetus was an independent risk factor for either PE or FGR (adjusted odds ratio: 1.169 or 1.563;95% confidence interval: 1.036-1.319 or 1.349-1.810, respectively). In twin pregnancies, the incidence of early-onset PE was greater in pregnancies with two females compared with two males or one male plus one female (4.6% (46/1003)vs. 4.1% (54/1305)vs. 2.4% (33/1391),P < 0.05). Female-female twins was an independent risk factor for PE (adjusted odds ratio: 1.367, 95% confidence interval: 1.011-1.849), especially early-onset PE.Conclusion: The female fetus was associated with PE in both singleton and twin pregnancies and was also a risk factor of FGR in singleton pregnancies. | Shilei Bi Lizi Zhang Zhijian Wang Jingman Tang Sushan Xie Jingjin Gong Lin Lin Luwen Ren Lijun Huang Shanshan Zeng Jingsi Chen Lili Du Dunjin Chen | 2021 | Maternal-Fetal Medicine2021，3，1： | 1 |
| 8 | Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta显示文摘Objective:To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta(PA).Methods:This case-control study included clinical data from singleton mothers with a history of cesarean section in 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017.According to the intraoperative findings after delivery,the study population was divided into PA and non-PA groups.We compared the pregnancy outcomes between the two groups,used multivariate logistic regression to analyze the risk factors for placental accreta.Results:For this study we included 11,074 pregnant women with a history of cesarean section;and of these,869 cases were in the PA group and 10,205 cases were in the non-PA group.Compared with the non-PA group,the probability of postpartum hemorrhage(236/10,205,2.31%vs.283/869,32.57%),severe postpartum hemorrhage(89/10,205,0.87%vs.186/869,21.75%),diffuse intravascular coagulation(3/10,205,0.03%vs.4/869,0.46%),puerperal infection(33/10,205,0.32%vs.12/869,1.38%),intraoperative bladder injury(1/10,205,0.01%vs.16/869,1.84%),hysterectomy(130/10,205,1.27%vs.59/869,6.79%),and blood transfusion(328/10,205,3.21%vs.231/869,26.58%)was significantly increased in the PA group(P<0.05).At the same time,the neonatal birth weight 3250.00(2950.00–3520.00)g vs.2920.00(2530.00–3250.00)g),the probability of neonatal comorbidities(245/10,205,2.40%vs.61/869,7.02%),and the rate of neonatal intensive care unit admission(817/10,205,8.01%vs.210/869,24.17%)also increased significantly(P<0.05).Weight(odds ratio)(OR)=1.03,95%confidence interval(CI):1.01–1.05)),parity(OR=1.18,95%CI:1.03–1.34),number of miscarriages(OR=1.31,95%CI:1.17–1.47),number of previous cesarean sections(OR=2.57,95%CI:2.02–3.26),history of premature rupture of membrane(OR=1.61,95%CI:1.32–1.96),previous cesarean-section transverse incisions(OR=1.38,95%CI:1.12–1.69),history of placenta previa(OR=2.44,95%CI:1.50–3.96),and the combination of prenatal hemorrhage(OR=9.95,95%CI:8.42–11.75)and placenta previa(OR=91.74,95%CI:74.11–113.56)were all independent risk factors for PA.Conclusion:There was an increased risk of adverse outcomes in pregnancies complicated by PA in women with a history of cesarean section,and this required close clinical attention.Weight before pregnancy,parity,number of miscarriages,number of previous cesarean sections,history of premature rupture of membranes,past transverse incisions in cesarean sections,a history of placenta previa,prenatal hemorrhage,and placenta previa were independent risk factors for pregnancies complicated with PA in women with a history of cesarean section.These independent risk factors showed a high value in predicting the risk for placentab accreta in pregnancies of women with a history of cesarean section. | Yingyu Liang Lizi Zhang Shilei Bi Jingsi Chen Shanshan Zeng Lijun Huang Yulian Li Minshan Huang Hu Tan Jinping Jia Suiwen Wen Zhijian Wang Yinli Cao Shaoshuai Wang Xiaoyan Xu Ling Feng Xianlan Zhao Yangyu Zhao Qiying Zhu Hongbo Qi Lanzhen Zhang Hongtian Li Lili Du Dunjin Chen | 2022 | Maternal-Fetal Medicine2022，4，3： | 1 |
| 9 | Exploring Experiences with '321' Model Management for High-Risk Pregnancy: A Qualitative Study显示文摘To editor:In recent years,obstetricians have needed to managemore complex pregnancies involving acute and chronicmedical disorders,and a greater number of pregnancieseach year are now delivered by critical care services.1Datafrom the United States show that poorly controlled maternal medical conditions can have an adverse impact on preg-nancy outcomes. | Wen Sun Peili Du Lin Yu Xiaoyi Wang Fang He Jingsi Chen Chunhong Su Dunjin Chen | 2023 | Maternal-Fetal Medicine2023，5，1： | 0 |
| 10 | Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection显示文摘The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide and threatened human’s health.With the passing of time,the epidemiology of coronavirus disease 2019 evolves and the knowledge of SARS-CoV-2 infection accumulates.To further improve the scientific and standardized diagnosis and treatment of maternal SARS-CoV-2 infection in China,the Chinese Society of Perinatal Medicine of Chinese Medical Association commissioned leading experts to develop the Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection under the guidance of the Maternal and Child Health Department of the National Health Commission.This recommendations includes the epidemiology,diagnosis,management,maternal care,medication treatment,care of birth and newborns,and psychological support associated with maternal SARS-CoV-2 infection.It is hoped that the recommendations will effectively help the clinical management of maternal SARS-CoV-2 infection. | Dunjin Chen Yue Dai Xinghui Liu Hongbo Qi Chen Wang Lan Wang Yuan Wei Xiaochao Xu Chuan Zhang Lingli Zhang Yuquan Zhang Ruihua Zhao Yangyu Zhao Borong Zhou Ai-Ling Wang Huixia Yang Li Song | 2023 | Maternal-Fetal Medicine2023，5，2： | 0 |
| 11 | Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19显示文摘Objective:This study aimed to investigate the immune response of a pregnant woman who recovered from the coronavirus disease 2019(COVID_(R)S)by using single-cell transcriptomic profiling of peripheral blood mononuclear cells(PBMCs)and to analyze the properties of different immune cell subsets.Methods:PBMCs were collected from the COVID_(R)S patient at 28 weeks of gestation,before a cesarean section.The PBMCs were then analyzed using single-cell RNA sequencing.The transcriptional profiles of myeloid,T,and natural killer(NK)cell subsets were systematically analyzed and compared with those of healthy pregnant controls from a published single-cell RNA sequencing data set.Results:We identified major cell types such as T cells,B cells,NK cells,and myeloid cells in the PBMCs of our COVID_(R)S patient.The increase of myeloid and B cells and decrease of T cells and NK cells in the PBMCs in this patient were quite distinct compared with that in the control subjects.After reclustering and Augur analysis,we found that CD16 monocytes and mucosal-associated invariant T(MAIT)cells were mostly affected within different myeloid,T,and NK cell subtypes in our COVID_(R)S patient.The proportion of CD16 monocytes in the total myeloid population was increased,and the frequency of MAIT cells in the total T and NK cells was significantly decreased in the COVID-RS patient.We also observed significant enrichment of gene sets related to antigen processing and presentation,T-cell activation,T-cell differentiation,and tumor necrosis factor superfamily cytokine production in CD16 monocytes,and enrichment of gene sets related to antigen processing and presentation,response to type II interferon,and response to virus in MAIT cells.Conclusion:Our study provides a single-cell resolution atlas of the immune gene expression patterns in PBMCs from a COVID_(R)S patient.Our findings suggest that CD16-positive monocytes and MAIT cells likely play crucial roles in the maternal immune response against severe acute respiratory syndrome coronavirus 2 infection.These results contribute to a better understanding of the maternal immune response to severe acute respiratory syndrome coronavirus 2 infection and may have implications for the development of effective treatments and preventive strategies for the coronavirus disease 2019 in pregnant women. | Lili Du Yingyu Liang Xiaoyi Wang Lijun Huang Xingfei Pan Jingsi Chen Dunjin Chen | 2023 | Maternal-Fetal Medicine2023，5，2： | 0 |
| 12 | Expert Opinion on Placenta Accreta Spectrum Disorders in China显示文摘Introduction In March 2018,the International Federation of Gynecology and Obstetrics(FIGO)proposed an inclusive standardized terminology of placenta accreta spectrum(PAS)disorders.1 This grading separates PAS into three categories:placenta adherenta or creta(PC),placenta increta(PI)and placenta percreta(PP).2 The aim of this expert opinion was to share the current knowledge on the diagnosed management of PAS in China. | Jie Yan Dunjin Chen Huixia Yang | 2021 | Maternal-Fetal Medicine2021，3，4： | 0 |
| 13 | The effect of maternal BDE-209 exposure on offsping's expression of MAP-1B and S100 in hippocampus of the rats显示文摘Objective:To study the effect of maternal BDE-209 (brominated Diphenyl Ethers-209)exposure on the expression of microtubule-associated protein-1b (map-1b) and S-100 in rat's hippocampus of the offspring by RT-PCR.Methods:Peanut oil suspensions of commercial deca-BDE was given in dose of 300 mg/(kg·d) by oral gavage throughout gestation and lactation in experimental group.The control group was administered only with the same capacity of peanut oil at the same time.The expression of MAP-1B in the hippocampus of the offspring's rats were tested when the pups were newborn,7days,14 days,21days and 45days old respectively by means of RT-PCR.Result:MAP-1B protein showed a statistically significantly lower concentration in the groups 14 days,21days,45days than that of the control groups.The expression of S-100 in the group which received with deca-BDE by RT-PCR showed higher than that of control groups.But only the 45days groups had significant difference of expression of MAP-1B protein compared with the control groups(P<0.05).Conclusions:Maternal BDE-209 exposure during the period of pregnancy will diminish the expression of map-1b protein in hippocampus of offspring's rats. | Yu Lin Su Tao Chen Shengqiang Chen Dunjin | 2008 | 现代妇产科进展2008，17，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员