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| 1 | Highly efficient and precise base editing in discarded human tripronuclear embryos显示文摘 | Guanglei Li Yajing Liu Yanting Zeng Jianan Li Lijie Wang Guang Yang Dunjin Chen Xiaoyun Shang Jia Chen Xingxu Huang Jianqiao Liu | 2017 | Protein & Cell2017，8，10： | 8 |
| 2 | Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats显示文摘Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients.In this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats.Gelatin methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding method.The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance.Metformin,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic rats.The drug release period could be significantly prolonged by improving the cross-link density of GelMA-MNs.The results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment. | Zhiyong Zeng Guohua Jiang Tianqi Liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi | 2021 | Bio-Design and Manufacturing2021，4，4： | 4 |
| 3 | Plant functional trait diversity and structural diversity co-underpin ecosystem multifunctionality in subtropical forests显示文摘Tree species diversity is assumed to be an important component in managing forest ecosystems because of effects on multiple functions or ecosystem multifunctionality.However,the importance of tree diversity in determining multifunctionality in structurally complex subtropical forests relative to other regulators(e.g.,soil microbial diversity,stand structure,and environmental conditions)remains uncertain.In this study,effects of aboveground(species richness and functional and structural diversity)and belowground(bacterial and fungal diversity)biodiversity,functional composition(community-weighted means of species traits),stand structure(diameter at breast height and stand density),and soil factors(pH and bulk density)on multifunctionality(including biomass production,carbon stock,and nutrient cycling)were examined along a tree diversity gradient in subtropical forests.The community-weighted mean of tree maximum height was the best predictor of ecosystem multifunctionality.Functional diversity explained a higher proportion of the variation in multifunctionality than that of species richness and fungal diversity.Stand structure-played an important role in modulating the effects of tree diversity on multifunctionality.The work highlights that species composition and maximizing forest structural complexity are effective strategies to increase forest multifunctionality while also conserving biodiversity in the management of multifunctional forests under global environmental changes. | Shuai Ouyang Mengmeng Gou Pifeng Lei Yue Liu Liang Chen Xiangwen Deng Zhonghui Zhao Yelin Zeng Yanting Hu Changhui Peng Wenhua Xiang | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 4 | Growth Performance of Cypress (Cupressus funebris) Trees in Progeny Test Plantations显示文摘Based on the 6-year-old young forests of 40 cypress(Cupressus funebris) families from four provenances(Fengdu County, Youyang County and Zhong County of Chongqing City, and Qiandao Lake in Zhejiang Province), differences in growth traits between families and provenances were studied to select excellent families, so as to provide necessary data support for the upgrading of cypress seed gardens and inferior thinning of seed gardens. The results showed that there were significant differences in tree height, diameter at one meter height, crown width and growth potential between families and provenances. The coefficients of variation among families were 10.25%, 7.19%, 5.91% and 0.98%, respectively, and the coefficients of variation in tree height and diameter at one meter height among provenances were 7.25% and 12.58%, respectively, indicating that the tree height and diameter at one meter height of the superior cypress tree families were rich in variation among families and provenances, and there was potential for high-generation breeding. According to the selection rate of 15%, six excellent families for afforestation(Feng 8, Shi 4, Feng 1, Ye 14, Shi 3, and Ye 6) were screened. The average diameter at one meter height, tree height and crown width of the six excellent families were, respectively, 2.97 cm, 3.39 and 0.78 m, which were 18.82%, 12.70% and 15.42% higher than the family average, respectively, and 15.09%, 9.79% and 15.53% higher than the control group, respectively. | Angui DENG Yong PENG Xiaomei TAN Wendong ZENG Yujun LUO Changwan TAN Yanting LIU Zhengyan LIU Chenyang WANG | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 5 | Multivariety and multimanufacturer drug identification based on near-infrared spectroscopy and recurrent neural network显示文摘Near-infrared(NIR)spectral analysis,which has the advantages of rapidness,nondestruction and high-efficiency,is widely used in the detection of feed,food and mineral.In terms of qualitative identification,it can also be used for the discriminant analysis of medicines.Long short-term memory(LSTM)neural network,bidirectional long short-term memory(BiLSTM)neural network and gated recurrent unit(GRU)network are variants of the recurrent neural network(RNN).The potential relationship between nonlinear features learned from the sequence by these variants is used to complete the missions infields such as natural language processing,signal classification and video analysis.Since the effect of these variants in drug identification is still to be studied,this paper constructs a multiclassifier of these three variants,using compoundα-keto acid tablets produced by four manufacturers and repaglinide tablets produced by five manufacturers as the research object.Then,the paper analyzes the impacts of seven different preprocessed methods on the drug NIR data by constructing different layers of LSTM,BiLSTM and GRU networks and compares different classification model indicators and training time of each model.When the spectrum data are pre-processed by z-score normalization,the GRU-3 model has the best accuracy in all models.The BiLSTM models are better for analyzing high coincidence data.The method proposed in this paper can be further extended to other NIR spectroscopy data sets. | Wenjie Zeng Yunqi Qiu Yanting Huang Qingping Sun Zhuoya Luo | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 0 |
| 6 | Characterization and comparison of two C-type lectins with novel key motifs from mud crab Scylla paramamosain显示文摘As an important pattern recognition receptor(PRR)in the innate immune system,C-type lectin plays an important role in the innate immune process of invertebrates.Two C-type lectins Sp CTL-C and Sp CTL-D were characterized from mud crab(Scylla paramamosain).The predicted Sp CTL-C and Sp CTL-D proteins both contain a single carbohydrate-recognition domain(CRD)with key motif Gln-Pro-Ala(QPA)and Met-Pro-Ala(MPA),respectively.Sp CTL-C and Sp CTL-D transcripts distributed in all examined tissues,and the expression level was the highest in hepatopancreas.As PRR,the purifi ed recombinant proteins r Sp CTL-C and r Sp CTL-D have high affi nity for three kinds of pathogen-associated molecular patterns(PAMPs):β-glucan,lipopolysaccharide,and peptidoglycan.Besides,r Sp CTL-D can bind to all nine microorganisms tested,while r Sp CTL-C can bind to seven microorganisms except for Staphylococcus aureus and Micrococcus luteus.Both r Sp CTL-C and r Sp CTL-D showed agglutination activity towards fungi Pichia pastoris and Saccharomyces cerevisiae.However,r Sp CTL-C and r Sp CTL-D exhibited diff erent antimicrobial activities:r Sp CTL-D has a certain inhibitory eff ect on the growth of Vibrio fl uvialis and M.luteus,while r Sp CTL-C has no obvious inhibitory activity.The results show that r Sp CTL-C and r Sp CTL-D had better phagocytosis-promoting eff ect on M.luteus than the negative control.Meanwhile,both r Sp CTL-C and r Sp CTL-D had certain encapsulation-promoting activity.Collectively,two C-type lectins with novel key motifs make an important impact as PRR in immune response towards pathogens.At the same time,they play diff erent functions in the innate immunity of mud crab S.paramamosain. | Boxin ZENG Taiwei DONG Yanting XIA Shun YANG Mengmeng HUANG Hui FEI | 2022 | Journal of Oceanology and Limnology2022，40，4： | 0 |
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