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24篇 您的检索式：作者名="Dunger A"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Polycystic ovaries and eating disorders: are they related 显示文摘	Michelmore K F Balen A H Dunger D B	2001	Hum Reprod2001，16，4：	1
3	Peripubertal changes in circulating anti-mullerian hormone levels in girls 显示文摘	Lashen H Dunger DB Ness A	2013	Fertility & Sterility2013，99，：	1
4	Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA 显示文摘	Dunger A Augstein P Schmidt S	1996	J Autoimmun1996，9，3：	1
5	Peripubertal changes in circulat- ing antimullerian hormone levels in girls 显示文摘	Lashen H Dunger DB Ness A	2013	Fertil Steril2013，99，7：	1
6	Identification of interleukin-linduced apotptosis in rat islet using in situ specific labeling of fragmented DNA 显示文摘	Dunger A Augstein P Schmidt S	1996	Autoimmun1996，9，3：	1
7	Association between postnatal catch-up growth and obesity in childhood: prospective cohort study 显示文摘	Ong K Ahmed ML Emmett PM Michael A David P Dunger B	2000	BMJ2000，320，7240：	1
8	Prevention of autoimmune diabetes in NOD mice by troglitazone is asociated with modulation of ICAM - 1 expression on pancreatic islet cells and IFN - gamma expression in splenic T cells显示文摘	Augstein P Dunger A Heinke P	2003	Biochem Biophys Res Commun2003，304，2：	1
9	Improved in vivo pancreatic islet function after prolonged in vitro islet culture显示文摘	Fraga DW Callicutt CS Gerling IC Sabek OM Kotb MY Dimitriadis G Crowne E Clark A Dunger DB	2001	Transplantation2001，72，11：	1
10	Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells显示文摘	Augstein P Dunger A Heinke P	2003	Biochem Biophys Res Commun2003，304，2：	1
11	Identification of interleukin-1 induced apoptosis in rat islets using in situ specific labelling of fragmented DNA 显示文摘	Dunger A Augstein P Schmidt S	1996	Autoimmun1996，9，3：	1
12	Identification of interleukin1induced apoptosis in rat islet using in situ specific labeling of fragmented DNA显示文摘	Dunger A Augstein P Schmidt S	1996	Autoimmun1996，9，：	1
13	Improved in vivo pancreatic islet function after prolonged in vitro islet culture 显示文摘	Gaber AO Fraga DW Callicutt CS Gerling IC Sabek OM Kotb MY Dimitriadis G Crowne E Clark A Dunger DB	2001	Transplantation2001，72，11：	1
14	Reversibility of the acute toxic effect of cyclosporin A on pancreatic B cells of Wistar rats 显示文摘	Hahn H J Dunger A Laube F	1986	Diabetologia1986，29，：	1
15	Tumor necrosis factor-or and interferon-γ inhibit insulin secretion and cause DNA damage in islets 显示文摘	Dunger A Cuunigam JM Green IC	1996	Diabetes1996，45，：	1
16	Tumor necrosis factor-αand interferon-γ inhibit insulin secretion and cause DNA damage in unweaned-rat islet 显示文摘	Dunger A Cuunigam JM Green IC	1996	Diabetes1996，45，2：	1
17	Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM - 1 expression on pancreatic islet cells and IFN - gamma expression in splenic T cells 显示文摘	AUGSTEIN P DUNGER A HEINKE P	2003	Biochem Biophys Res Commun2003，304，2：	1
18	Interleukin- 1β-induces apoptosis in insulin-producing cells显示文摘	Dunger A Schlosser M Ziegler B	1995	Diabetologia1995，38，1：	1
19	Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells 显示文摘	Augstein P Dunger A Heinke P	2003	Biochem Biophys Res Commun2003，304，2：	1
20	Anogenital distance from birth to 2 years:a population study显示文摘	Thankamony A Ong KK Dunger DB	2009	Environ Health Perspect2009，117，11：	1

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