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| 1 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 2 | Unusual peroxidase activity of a myoglobin mutant with two distal histidines显示文摘由在精子鲸鱼肌球素(Mb ) 保留本国的远侧的 His64,第二远侧的 histidine 被变异的 Leu29 在 Mb 设计到 His29。L29H Mb 的结果的异种与野类型 Mb 的相比与积极 cooperativity 展出一项不平常的提高的 peroxidase 活动。有二合作远侧的 histidines 的新酶没在本国的 peroxidase 被发现,它强调合理蛋白质设计的创造。 | Wei Wei Guo Dun Wan Li Fu Liao Ying Wu Lin | 2012 | Chinese Chemical Letters2012，23，6： | 3 |
| 3 | Early Report of the Source Characteristics,Ground Motions,and Casualty Estimates of the 2023 Mw 7.8 and 7.5 Turkey Earthquakes显示文摘INTRODUCTION,At 01:17 UTC(04:17 on local time)on Feb.6,2023,a devastating earthquake with a moment magnitude(Mw)7.8 occurred in the Gaziantep,southern Turkey.The earthquake was located at 37.174°N and 37.032°E,with a hypocentral depth of 17.9 km as reported by the United States Geological Survey(USGS). | Wenkai Chen Gang Rao Dengjie Kang Zhifan Wan Dun Wang | 2023 | Journal of Earth Science2023，34，2： | 3 |
| 4 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 5 | Influence of sulphate-reducing bacteria on environmental parameters and marine corrosion behavior of Q235 steel in aerobic conditions显示文摘 | Yi Wan Dun Zhang Huaiqun Liu Yongjuan Li Baorong Hou | 2009 | Electrochimica Acta2009，，5： | 2 |
| 6 | Green approach to fabrication of a super-hydrophobic film on copper and the consequent corrosion resistance显示文摘 | Peng Wang Dun Zhang Ri Qiu Yi Wan Jiajia Wu | 2013 | Corrosion Science2013，，： | 2 |
| 7 | Influence of sulphate-reducing bacteria on environmental parameters and marine corrosion behavior of Q235 steel in aerobic conditions 显示文摘 | WAN Yi ZHANG Dun LIU Huai-qun | 2010 | Elec trochim Acta2010，55，5： | 1 |
| 8 | Influence of sulphate-reducing bacteria on environmental parameters and marine corrosion behavior of Q235 steel in aerobic conditions显示文摘 | WAN Yi ZHANG Dun LIU Huai-qun | | 0，，05： | 1 |
| 9 | Manganese oxide–graphene composite as an efficient catalyst for 4-electron reduction of oxygen in alkaline media显示文摘 | Jiajia Wu Dun Zhang Yi Wang Yi Wan | 2012 | Electrochimica Acta2012，，： | 1 |
| 10 | Influence of sulphate-reducing bacteria on environmental paramet- ers and marine corrosion behavior of Q235 steel in aerobic conditions显示文摘 | Wan Vi Zhang Dun Liu Huaiqun et a1 | 2010 | Electrochimica Acta2010，55，5： | 1 |
| 11 | Determination of sulphatereducing bacteria based on vancomycin-functionalised magnetic nanoparticles using a modification-free quartz crystal micmbalance显示文摘 | Wan Yi Zhang Dun Hou Baorong | 2010 | Biosens Bioelectron2010，25，： | 1 |
| 12 | Impedimetric immunosensor doped with reduced graphene sheets fabri-cated by controllable electrodeposition for the non-labelled detection of bacteria显示文摘 | WAN Yi LIN Zhi-feng ZHANG Dun | 2011 | Biosens Bioelectron2011，26，5： | 1 |
| 13 | Preliminary report of the September 5,2022 M_(S) 6.8 Luding earthquake,Sichuan,China显示文摘The 2022 M_(S)6.8 Luding earthquake is the strongest earthquake in Sichuan Province, Western China, since the 2017 M_(S)7.0 Jiuzhaigou earthquake. It occurred on the Moxi fault in the southeastern segment of the Xianshuihe fault, a tectonically active and mountainous region with severe secondary earthquake disasters. To better understand the seismogenic mechanism and provide scientific support for future hazard mitigation, we summarize the preliminary results of the Luding earthquake, including seismotectonic background, seismicity and mainshock source characteristics and aftershock properties, and direct and secondary damage associated with the mainshock.The peak ground displacements in the NS and EW directions observed by the nearest GNSS station SCCM are ~35 mm and ~55 mm, respectively, resulting in the maximum coseismic dislocation of 20 mm along the NWW direction, which is consistent with the sinistral slip on the Xianshuihe fault. Back-projection of teleseismic P waves suggest that the mainshock rupture propagated toward south-southeast. The seismic intensity of the mainshock estimated from the back-projection results indicates a Mercalli scale of Ⅷ or above near the ruptured area,consistent with the results from instrumental measurements and field surveys. Numerous aftershocks were reported, with the largest being M_(S)4.5. Aftershock locations(up to September 18, 2022) exhibit 3 clusters spanning an area of 100 km long and 30 km wide. The magnitude and rate of aftershocks decreased as expected, and the depths became shallower with time. The mainshock and two aftershocks show left-lateral strike-slip focal mechanisms. For the aftershock sequence, the b-value from the Gutenberg-Richter frequency-magnitude relationship, h-value, and p-value for Omori’s law for aftershock decay are 0.81, 1.4, and 1.21, respectively, indicating that this is a typical mainshock-aftershock sequence. The low b-value implies high background stress in the hypocenter region. Analysis from remote sensing satellite images and UAV data shows that the distribution of earthquake-triggered landslides was consistent with the aftershock area. Numerous small-size landslides with limited volumes were revealed, which damaged or buried the roads and severely hindered the rescue process. | Yanru An Dun Wang Qiang Ma Yueren Xu Yu Li Yingying Zhang Zhumei Liu Chunmei Huang Jinrong Su Jilong Li Mingxiao Li Wenkai Chen Zhifan Wan Dengjie Kang Baoshan Wang | 2023 | Earthquake Research Advances2023，3，1： | 1 |
| 14 | Determination of sulphate-reducing bacteria based on vancomycin-functionalised magnetic nanoparticles using a modification-free quartz crystal microbalance显示文摘 | Yi Wan Dun Zhang Baorong Hou | 2009 | Biosensors and Bioelectronics2009，，7： | 1 |
| 15 | The Effect of Tai Chi on Psychosocial Well-being: A Systematic Review of Randomized Controlled Trials显示文摘 | Wei Chun Wang Anthony Lin Zhang Bodil Rasmussen Li-Wei Lin Trisha Dunning Seung Wan Kang Byung-Joo Park Sing Kai Lo | 2009 | Journal of Acupuncture and Meridian Studies2009，，3： | 1 |
| 16 | Experimental preparation of topologically ordered states via adiabatic evolution显示文摘Topological orders are a class of exotic states of matter characterized by patterns of long-range entanglement. Certain topologically ordered systems are proposed as potential realization of fault-tolerant quantum computation. Topological orders can arise in two-dimensional spin-lattice models. In this paper, we engineer a time-dependent Hamiltonian to prepare a topologically ordered state through adiabatic evolution. The other sectors in the degenerate ground-state space of the model are obtained by applying nontrivial operations corresponding to closed string operators. Each sector is highly entangled, as shown from the completely reconstructed density matrices. This paves the way towards exploring the properties of topological orders and the application of topological orders in topological quantum memory. | ZhiHuang Luo Jun Li ZhaoKai Li Ling-Yan Hung Yi Dun Wan XinHua Peng JiangFeng Du | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，8： | 0 |
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