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| 1 | The kisspep-tin/ gonadotropin releasing hormone pathway and molecular signalingof puberty in fish显示文摘 | FILBY A L VAN AEHLE R DUITMAN J | 2008 | Biol Reprod2008，78，2： | 1 |
| 2 | The my- cosubtilin synthetase of Bacillus subtilis ATCC6633:A multi- functional hybrid between a peptide synthetase,an amino trans- ferase, and a fatty acid synthase显示文摘 | DUITMAN E H HAMOEN L W REMBOLD M | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 3 | The kisspeptin/gonadotropinreleasing hormone pathway and molecular signaling of puberty in fish显示文摘 | Filby A L Van Aerle R Duitman J | | 0，，02： | 1 |
| 4 | How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha 显示文摘 | Duitman EH Orinska Z Bulanova E | 2008 | Mol Cell Biol2008，28，15： | 1 |
| 5 | Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases显示文摘 | Duitman E H Wyczawski D Boven L G | 2007 | Appl Environ Microbiol2007，73，11： | 1 |
| 6 | Functional Analysis of dsRNAs (L1,L3,LS,and M2) Associated with Isometric 34-nm Virions of Agaricus bisporus (White Button Mushroom)显示文摘 | Van der Lende T R Duitman E H Gunnewijk M G W | 1996 | Virology1996，217，： | 1 |
| 7 | Soluble interleukin(IL)-15R{alpha} is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15显示文摘 | Bulanova E Budagian V Duitman E | 2007 | J Biol Chem2007，282，13： | 1 |
| 8 | How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: Lessons from interleukin-15 (IL-15 )/IL-15 receptor alpha 显示文摘 | Duitman EH Orinska Z Bulanova E | 2008 | Sci Signal2008，28，15： | 1 |
| 9 | The mycosubtilin synthetase of Bacillus subtilis ATCC6633:a multifunctional hybrid between a peptide synthetase,an amino transferase,and a fatty acid synthase显示文摘 | Duitman E H Hamoen L W Rembold M Venema G Seitz H Saenger W Bernhard F Reinhardt R Schmidt M Ullrich C Stein T Leenders F Vater J | | 0，，： | 1 |
| 10 | How a cytoidne is chaperoned through the secretory pathway by complexing with its own receptor:lessons from interleukin-15 (IL-15)/IL-15 receptor alpha显示文摘 | Duitman EH Orinska Z Bulanova E | 2008 | Mol Cell Biol2008，28，： | 1 |
| 11 | Soluble interleukin (IL)-15R {alpha} is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15 显示文摘 | Bulanova E Budagian V Duitman E | 2007 | J Biol Chem2007，282，13： | 1 |
| 12 | The mycosubtilin synthetase of Bacillus subtilis ATCC6633 : A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase 显示文摘 | Duitman E H Hamoen L W Rembold M | 1999 | Proc NatlAcadSci1999，96，13： | 1 |
| 13 | CCAAT/enhancer binding protein delta(C/EBPδ)deficiency does not affect bleomycin-induced pulmonary fibrosis显示文摘Background:Idiopathic pulmonary fibrosis is a devastating fibrotic diffuse parenchymal lung disorder that remains refractory to pharmacological therapies.Therefore,novel treatments are urgently required.CCAAT/enhancer binding protein delta(C/EBPδ)is a transcription factor that mediates critical cellular functions in pathophysiology and which was recently suggested to be a key regulatory component in IPF.The purpose of this study was to prove or refute the importance of C/EBPδin pulmonary fibrosis.Methods:Pulmonary fibrosis was induced by intranasal instillation of bleomycin into wild-type and C/EBPδdeficient mice.At different time intervals after bleomycin instillation,fibrosis was assessed by hydroxyproline analysis,histochemistry and q-PCR for fibrotic marker expression.Results:C/EBPδdeficient mice developed pulmonary fibrosis to a similar degree as wildtype mice as evident from similar Ashcroft scores,hydroxyproline levels and expression levels of collagen,fibronectin andα-smooth muscle actin at both 14 and 21 days after bleomycin instillation.The resolution of fibrosis,assessed at 48 days after bleomycin instillation,was also similar in wildtype and C/EBPδdeficient mice.In line with the lack of effect of C/EBPδon fibrosis progression/resolution,macrophage recruitment and/or differentiation were also not different in wildtype or C/EBPδdeficient mice.Conclusions:Overall,C/EBPδdoes not seem to affect bleomycin-induced experimental pulmonary fibrosis and we challenge the importance of C/EBPδin pulmonary fibrosis.Relevance for patients:This study shows that the transcription factor C/EBPδdoes not play a major role in the development of pulmonary fibrosis.Pharmacological targeting of C/EBPδis therefore not likely to have a beneficial effect for patients suffering from pulmonary fibrosis. | JanWillem Duitman Cong Lin Sophie Moog Madeleine Jaillet Yves Castier Aurélie Cazes Keren SBorensztajn Bruno Crestani CArnold Spek | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
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