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1篇 您的检索式：作者名="Madeleine Jaillet"

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		题名	作者	年代	出处	被引量
	1	CCAAT/enhancer binding protein delta(C/EBPδ)deficiency does not affect bleomycin-induced pulmonary fibrosis显示文摘Background:Idiopathic pulmonary fibrosis is a devastating fibrotic diffuse parenchymal lung disorder that remains refractory to pharmacological therapies.Therefore,novel treatments are urgently required.CCAAT/enhancer binding protein delta(C/EBPδ)is a transcription factor that mediates critical cellular functions in pathophysiology and which was recently suggested to be a key regulatory component in IPF.The purpose of this study was to prove or refute the importance of C/EBPδin pulmonary fibrosis.Methods:Pulmonary fibrosis was induced by intranasal instillation of bleomycin into wild-type and C/EBPδdeficient mice.At different time intervals after bleomycin instillation,fibrosis was assessed by hydroxyproline analysis,histochemistry and q-PCR for fibrotic marker expression.Results:C/EBPδdeficient mice developed pulmonary fibrosis to a similar degree as wildtype mice as evident from similar Ashcroft scores,hydroxyproline levels and expression levels of collagen,fibronectin andα-smooth muscle actin at both 14 and 21 days after bleomycin instillation.The resolution of fibrosis,assessed at 48 days after bleomycin instillation,was also similar in wildtype and C/EBPδdeficient mice.In line with the lack of effect of C/EBPδon fibrosis progression/resolution,macrophage recruitment and/or differentiation were also not different in wildtype or C/EBPδdeficient mice.Conclusions:Overall,C/EBPδdoes not seem to affect bleomycin-induced experimental pulmonary fibrosis and we challenge the importance of C/EBPδin pulmonary fibrosis.Relevance for patients:This study shows that the transcription factor C/EBPδdoes not play a major role in the development of pulmonary fibrosis.Pharmacological targeting of C/EBPδis therefore not likely to have a beneficial effect for patients suffering from pulmonary fibrosis.	JanWillem Duitman Cong Lin Sophie Moog Madeleine Jaillet Yves Castier Aurélie Cazes Keren SBorensztajn Bruno Crestani CArnold Spek	2017	Journal of Clinical & Translational Research2017，3，4：	0

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