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| 1 | Freeform imaging systems:Fermat's principle unlocks'first time right'design显示文摘For more than 150 years,scientists have advanced aberration theory to describe,analyze and eliminate imperfections that disturb the imaging quality of optical components and systems.Simultaneously,they have developed optical design methods for and manufacturing techniques of imaging systems with ever-increasing complexity and performanee up to the point where they are now including optical elements that are unrestricted in their surface shape.These so-called optical freeform elements offer degrees of freedom that can greatly extend the functionalities and further boost the specifications of state-of-the-art imaging systems.However,the drastically increased number of surface coefficients of these freeform surfaces poses severe challenges for the optical design process,such that the deployme nt of freeform optics remained limited until today.In this paper,we present a deterministic direct optical design method for freeform imaging systems based on differential equations derived from Fermats principle and solved using power series.The method allows calculating the optical surface coefficients that ensure minimal image blurring for each individual order of aberrations.We demonstrate the systematic,deterministic,scalable,and holistic character of our method with catoptric and catadioptric design examples.As such we introduce a disruptive methodology to design optical imaging systems from scratch,we largely reduce the 'trial-and-error',approach in present-day optical design,and we pave the way to a fast-track uptake of freeform elements to create the nextgeneratio n high-end optics.We include a user application that allows users to experience this unique design method hands-on. | Fabian Duerr Hugo Thienpont | 2021 | Light(Science & Applications)2021，10，6： | 5 |
| 2 | Projected effectiveness of HIV detection during early infection and rapid ART initiation among MSM and transgender women in Peru: A modeling study显示文摘Background:The Sabes study,a treatment as prevention intervention in Peru,tested the hypothesis that initiating antiretroviral therapy(ART)early in HIV infection when viral load is high,would markedly reduce onward HIV transmission among high-risk men who have sex with men(MSM)and transgender women(TW).We investigated the potential population-level benefits of detection of HIV early after acquisition and rapid initiation of ART.Methods:We designed a transmission dynamic model to simulate the HIV epidemic among MSM and TW in Peru,calibrated to data on HIV prevalence and ART coverage from 2004 to 2011.We assessed the impact of an intervention starting in 2018 in which up to 50%of the new infections were diagnosed within three months of acquisition and initiated on ART within 1 month of diagnosis.We estimated the impact of the intervention over 20 years using the cumulative prevented fraction of new HIV infections compared to scenarios without intervention.Findings:Our model suggests that only 19%of the infected MSM and TW are virally suppressed in 2018 and 35%e40%of the new HIV infections are transmitted from contacts with acutely-infected partners.An intervention reaching 10%of all acutely infected MSM and TW is projected to prevent 13.3%[Uncertainty interval:11.9%e14.3%]of the new infections over 20 years and reduce HIV incidence in 2038 by 24%.Reaching 50%of all acutely infected MSM and TWwill increase the prevalence of viral suppression in 2038 to 59%and prevent 41%of expected infections over 20 years.Reaching 50%of the high-risk MSM and TW in acute phase would reduce HIV incidence in 2038 by 60%and prevent 36%of new infections between 2018 and 2038.Conclusions:Early detection of HIV infections and rapid initiation of ART among MSM is desirable as it would increase the effectiveness of the HIV prevention program in Peru.Targeting high-risk MSM and TW will be highly efficient. | Dobromir Dimitrov Daniel Wood Angela Ulrich David A.Swan Blythe Adamson Javier R.Lama Jorge Sanchez Ann Duerr | 2019 | Infectious Disease Modelling2019，4，1： | 2 |
| 3 | Neutrophil autoantibodies in ulcerative colitis familial aggregation and genetic heterogeneity 显示文摘 | Shanahan F Duerr R H Rotter J I | 1992 | Gastroenterology1992，103，2： | 1 |
| 4 | Water quanlity and microbial dynamics in shirmp ponds receiving bagasse-based feed 显示文摘 | VISSER P T DUERR E O | 1991 | World Aquaculture Soc1991，22，1： | 1 |
| 5 | PTEN mutations in gliomas and glioneuronal tumors 显示文摘 | Duerr EM Rollbrocker B Hayashi Y | 1998 | Oncogene1998，16，17： | 1 |
| 6 | A genome - wide association study identifies IL23R as an inflamma- tory bowel disease gene 显示文摘 | Duerr RH Taylor KD Brant SR | 2006 | Science2006，314，： | 1 |
| 7 | Manufactur- ing energy use in eight OECD countries 显示文摘 | HOWARTH R B SCHIPPER L DUERR P A | 1991 | Energy Economics1991，13，2： | 1 |
| 8 | The acceptability of the female and male condom:a randomized crossover trial显示文摘 | Kulczycki A Kim DJ Duerr A | 2004 | Perspect Sex Reprod Health2004，36，3： | 1 |
| 9 | Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai,Thailand显示文摘 | Cohen CR Duerr A Pruithithada N | 1995 | AIDS1995，9，9： | 1 |
| 10 | Comprehensive Allelotype and Genetic Analysis of 466 Human Nervous System Tumors显示文摘 | ANDREAS VON DEIMLING ROLF FIMMERS MATTHIAS C. SCHMIDT BERNHARD BENDER FRANK FASSBENDER JUDITH NAGEL ROLF JAHNKE PETER KASKEL EVA-MARIA DUERR JENS KOOPMANN DAVID MAINTZ STEPHANIE STEINBECK WOLFGANG WICK MICHAEL PLATTEN DANIEL J. MüLLER RENé PRZKORA ANDREAS | 2000 | JNEN: Journal of Neuropathology & Experimental Neurology2000，，6： | 1 |
| 11 | Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study) : a double blind, randomised, placebo-controlled, test-of-concept trial显示文摘 | Buchbinder S P Mehrotra D V Duerr A | 2008 | Lancet2008，372，9653： | 1 |
| 12 | PTEN mutations in gliomas and glioneuronal tumors显示文摘 | Duerr EM Rollbrocker B Hamashi Y | 1998 | Oncogene1998，16，17： | 1 |
| 13 | O-antigen delays lipopolysaccharide recognition and impairs antibacterial host defense in murine intestinal epithelial cells显示文摘 | Duerr CU Zenk SF Chassin C | 2009 | PLoS Pathogens2009，5，10： | 1 |
| 14 | PTEN mutations in gliomas and glioneuronal tumors显示文摘 | Rollbrocker B Hayashi Y | 1998 | Oncogene1998，16，17： | 1 |
| 15 | Phenolic compounds in apple juice-positive and negative effects显示文摘 | BARBIC I DUERR P | 1995 | Fruit Process1995，5，6： | 1 |
| 16 | Designating User Communities for Scientific Data:Challenges and Solutions显示文摘 | Parsons M A Duerr R | 2005 | Data Science Journal2005，，4： | 1 |
| 17 | A Genome-wide association study identiies lL23R as an inflammatory bowel disease gene显示文摘 | Duerr RH Taylor KD Brant SR | 2006 | Science2006，314，5804： | 1 |
| 18 | Complication of interval Laparoscopic tub',d sterilization: findings from the United States Collaboration Review of Sterilization 显示文摘 | Jamieson DJ Hillis SD Duerr A | 2000 | Obstetrics Gynecology2000，96，6： | 1 |
| 19 | Lares developments in the open-die forging industry显示文摘 | Duerr Oliver Frank Arno Grimm Walter | 2000 | Stahl un( Eisen2000，，： | 1 |
| 20 | An evaluation of sirolimus in renal transplantation显示文摘 | Halleck F Duerr M Waiser J | 2012 | Expert Opin Drug Metab Toxicol2012，8，： | 1 |
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