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| 1 | On the improved tensile strength and ductility of Mg-Sn-Zn-Mn alloy processed by aging prior to extrusion显示文摘This study investigated the influence of aging prior to extrusion(APE)on the tensile strength and ductility of as-extruded Mg-8.32Sn-1.85Zn-0.17Mn alloy.Results demonstrated that APE treatment dramatically increased the volume fraction of recrystallized grains,thereby decreasing the grain size of the as-extruded alloy.This phenomenon was primarily attributed to the particle-stimulated nucleation and pinning effect induced by large amounts of small Mg 2 Sn precipitates produced by the APE treatment and dynamic precipitation.The tensile yield strength increased from 242.4 MPa to 256.5 MPa after APE treatment.The improved tensile strength can be attributed to the enhanced grain boundary strengthening and precipitation strengthening.The ductility of the as-extruded alloy also markedly increased from 7.1%to 13.5%after the APE treatment.The improved ductility of APE alloy was attributed to the texture randomization,the activity of pyramidalslip and the suppressed formation of{10-11}contraction twins and coarse Mg 2 Sn phases. | Liping Zhong Yongjian Wang Yuchen Dou | 2019 | Journal of Magnesium and Alloys2019，7，4： | 8 |
| 2 | Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy显示文摘Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy.In the present study,a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid.Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly increased,which was associated with retinal ganglion cell death in diabetic retinas.The C/ERB homologous protein pathway directly contributed to glial reactivity,and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy.Our experimental findings indicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neuronal loss and vascular abnormalities,and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy. | Liping Yang Lemeng Wu Dongmei Wang Ying Li Hongliang Dou Mark O.M.Tso Zhizhong Ma | 2013 | Neural Regeneration Research2013，8，33： | 7 |
| 3 | Preparation of YSZ solid electrolyte by slip casting and its properties显示文摘Fully stabilized YSZ solid electrolyte was prepared by slip casting. The density was measured according to the Archimedes principle and the linear shrinkage was calculated from measuring the sizes of samples before and after sintering. XRD analysis was conducted to verify the phase structure of both the starting YSZ powder and the prepared YSZ electrolyte. The microstructure of fracture surface and the electrical properties of the samples sintered at different temperatures were investigated via SEM and a complex impedance method, respectively. By comparison of the properties and features among the samples, a slip casting method was established to be a simple way to manufacture high-quality YSZ electrolyte at the sintering temperature of 1550°C for 3 h, which provides a new approach for YSZ electrolyte with complex shapes and mass production. | DOU Jinga LI Heping XU Liping ZHANG Lei WANG Guangwei | 2009 | Rare Metals2009，28，4： | 5 |
| 4 | Preparation of CuCr alloys by thermit-reduction electromagnetic stirring显示文摘The influences of the additive CaF2, different molds, mold pre-heating temperature, electromagnetic stirring, and alloying elements on CuCr have been investigated respectively during the preparation of CuCr alloys by thermit-reduction electromagnetic stirring. The results indicate that the reasonable reactant mass ratio of CuO: Cr2O3: Al is 100:140:160; CaF2 can reduce the solidifica- tion point of slags to improve the metal separating efficiency from slags; the crystal particles become thinner because of the high cooling velocity in the metal mold; while casting in the graphite mold, the casting properties of CuCr improve with the increase of pre-heating temperature; the compact alloys are prepared at 500°C; electromagnetic stirring can prevent the growth of dendrite crys- tal into refine crystal particles, as well as homogenize Cu and Cr to improve the CuCr properties; the optimal stirring time is 7 min; when the alloying elements Ni and Co are added to the reactants, elements Cu and Cr can distribute evenly but the crystal particles become thick. | Zhihe Dou Tingan Zhang Haien Yu Liping Niu Xiaoli Jiang Huan Yang | 2007 | Journal of University of Science and Technology Beijing2007，14，6： | 4 |
| 5 | Outcomes of peripheral blood stem cell transplantation in patients from human leukocyte antigen matched or mismatched unrelated donors显示文摘 | Cao Tingting Li Yanfen Wang Quanshun Li Honghua Bo Jian Zhao Yu Jing Yu Wang Shuhong Zhu Haiyan Dou Liping Jia Bojun Gao Chunji Yu Li Huang Wenrong | 2014 | Chinese Medical Journal2014，，14： | 2 |
| 6 | Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment-specific factors involved in the regulation of MSC plasticity显示文摘Mesenchymal stem cells(MSCs),multipotent stromal cells,have attracted exten-sive attention in the field of regenerative medicine and cell therapy due to the capacity of self-renewal,multilineage differentiation,and immune regulation.MSCs have different cellular effects in different diseases,and even have markedly different curative effects with different tissue sources,indicating the plasticity of MSCs.The phenotypes,secreted factors,and proliferative,migratory,differentiating,and immunomodulatory effects of MSCs depend on certain mediators present in their microenvironment.Understanding microenvironmental factors and their internal mechanisms in MSC responses may help in subsequent prediction and improvement of clinical benefits.This review highlighted the recent advances in MSC plas-ticity in the physiological and pathological microenvironment and multiple microenviron-mental factors regulating MSC plasticity.It also highlighted some progress in the underlying molecular mechanisms of MSC remodeling in the microenvironment.It might provide refer-ences for the improvement in vitro culture of MSCs,clinical application,and in vivo induction.Copyrightª2020,Chongqing Medical University.Production and hosting by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh6owwbcc66fp569up.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Liping Tan Xuan Liu Huan Dou Yayi Hou | 2022 | Genes & Diseases2022，9，2： | 2 |
| 7 | Determine locking range of coherently combined fiber lasers joined by fiber couplers显示文摘 | Dou Ruhai Zhou Xia Zhang Liping | 2008 | Opt Int J Light Electron Opt2008，120，7： | 1 |
| 8 | Comparative Identification between Kadsura coccinea and Kadsura heteroclite显示文摘[Objectives]The purpose was to provide scientific basis for the identification and application of Kadsura coccinea and its chief adulterant Kadsura heteroclite.[Methods]The botanical characteristics,traits and microscopic morphology of the two plants were compared.[Results]K.coccinea was clearly distinguished from K.heteroclite in botanical characteristics,traits and microscopic morphology.[Conclusions]This study is of great significance to the identification and development of K.coccinea. | Xincheng QU Qimin HU Yunfeng HUANG Liping DOU | 2020 | Medicinal Plant2020，11，2： | 1 |
| 9 | Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer显示文摘Dear Editor,Early diagnosis is critical for successful treatment of gastric adenocarcinoma(GA).However,the sensitivities of tumor markers carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and CA72-4 for GA detection are approximately 20%[1],and the sensitivities of all markers combined for early gastric cancer detection is still very low[2].DNA methylation plays a major role in tumorigenesis and therefore has obvious potential as a non-invasive biomarker for cancer detection[3].Through genome-wide methylation analysis and histological verification,we previously identified ring finger protein 180(RNF180)as a novel preferentially methylated gene in GA[4,5]. | Yongzhan Nie Xianchun Gao Xiqiang Cai Zhen Wu Qiaoyi Liang Guobing Xu Na Liu Peng Gao Jingyu Deng Hongzhi Xu Zhanlong Shen Changqi Cao Fenrong Chen Nannan Zhang Yongxi Song Mingjun Sun Chengyin Liu Guangpeng Zhou Weili Han Jianhua Dou Huahong Xie Liping Yao Zhiguo Liu Gang Ji Xin Wang Qingchuan Zhao Lei Shang Daiming Fan Xiaoliang Han Jianlin Ren Han Liang Zhenning Wang Jinhai Wang Qi Wu Jun Yu Kaichun Wu the MAGIS Study Group | 2023 | Cancer Communications2023，43，11： | 0 |
| 10 | Next-generation sequencing revealed factors associated with cumulative incidence of relapse and leukemia-free survival in patients with newly diagnosed acute myeloid leukemia显示文摘BackgroundSeveral prognostic biomarkers have been validated for acute myeloid leukemia(AML),a heterogeneous hematopoietic malignancy.However,the factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in real-world patients with AML have not been well defined.MethodsThis study examined clinical and mutational data of 246 patients with newly diagnosed AML who received the traditional“3+7”regimen in PLA General Hospital from January 2008 to August 2020.Factors associated with CIR and LFS in patients newly diagnosed with AML were analyzed using next-generation sequencing.ResultsAdditional sex combs-like 1(ASXL1)and Serine/arginine-rich splicing factor 2(SRSF2)mutations were found to be associated with an increased risk of CIR and a reduced LFS in univariate analysis,while only SRSF2 mutations were associated with these factors in the multivariate analysis.Hyperleukocytosis maintained an independent effect on LFS in the multivariate analysis.Hematopoietic stem cell transplantation conferred a significant prognostic benefit on both CIR and LFS in our cohort.Furthermore,we validated the risk classification of patients with AML receiving traditional induction regimens across a broad age range.Based on next-generation sequencing results,we concluded that SRSF2 mutations were predictive of an increased risk of relapse,inferior LFS rates,and non-relapse mortality in patients with newly diagnosed AML.ConclusionThese findings indicate that patients with SRSF2 mutations might not benefit from the conventional“3+7”regimen.Our results may help in developing molecular stratification strategies and could guide treatment decisions for patients with newly diagnosed AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Mingyu Jia Jing Chen Nan Wang Fei Li Lixia Liu Jiayue Qin Chengcheng Wang Shanbo Cao Liping Dou Daihong Liu | 2023 | Cancer Pathogenesis and Therapy2023，1，1： | 0 |
| 11 | Characterization of germline development and identification of genes associated with germline specification in pineapple显示文摘Understanding germline specification in plants could be advantageous for agricultural applications.In recent decades,substantial efforts have been made to understand germline speci fication in several plant species,including Arabidopsis,rice,and maize.However,our knowledge of germline speci fication in many agronomically important plant species remains obscure.Here,we characterized the female germline speci fication and subsequent female gametophyte development in pineapple using callose staining,cytological,and whole-mount immunolocalization analyses.We also determined the male germline speci fication and gametophyte developmental timeline and observed male meiotic behavior using chromosome spreading assays.Furthermore,we identi fied 229 genes that are preferentially expressed at the megaspore mother cell(MMC)stage during ovule development and 478 genes that are preferentially expressed at the pollen mother cell(PMC)stage of anther development using comparative transcriptomic analysis.The biological functions,associated regulatory pathways and expression patterns of these genes were also analyzed.Our study provides a convenient cytological reference for exploring pineapple germline development and a molecular basis for the future functional analysis of germline speci fi cation in related plant species. | Lihua Zhao Liping Liu Yanhui Liu Xianying Dou Hanyang Cai Mohammad Aslam Zhimin Hou Xingyue Jin Yi Li Lulu Wang Heming Zhao Xiaomei Wang Adrien Sicard Yuan Qin | 2021 | Horticulture Research2021，8，1： | 0 |
| 12 | Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine显示文摘Background:Acute myeloid leukemia(AML)is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers.Decitabine,a deoxyribonucleic acid(DNA)methyltransferase(DNMT)in-hibitor,combined with cytarabine,aclarubicin hydrochloride,and granulocyte colony-stimulating factor(DCAG),has been used in patients newly diagnosed with AML.This regimen has been especially used in older and fragile patients who are immunocompromised or have co-morbidities,as well as those with specific gene mutations.However,the integration of molecular risk stratification and treatment guidance for the DCAG regimen has not been well defined.Therefore,this study aimed to investigate the genetic mutations associated with AML and establish appropriate treatment strategies for patients newly diagnosed with AML.Methods:This study analyzed the clinical data and genetic mutations based on next-generation sequencing(NGS)in 124 newly diagnosed patients with AML who received the DCAG regimen at the People's Liberation Army(PLA)General Hospital from January 2008 to August 2020.Factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in patients newly diagnosed with AML were analyzed.Results:The most adverse prognosis of DCAG-treated patients was observed in those with FLT3-ITD,KIT,PTPN11,GATA2,or IDH1 mutations during univariable analysis,whereas PTPN11 mutation was solely significant in multivariable analysis,with an increased likelihood of CIR(P=0.001)and reduced LFS duration(P=0.077).Hyperleukocytosis was maintained as an independent risk factor for increased CIR risk(P=0.044)and decreased LFS duration(P=0.042)in multivariable analysis.In this study,we validated the risk classification of patients with AML receiving an epigenetic modifier-based induction regimen across a broad age range.Conclusion:NGS demonstrated a dismal overall outcome in patients with the rare PTPN11 mutations,indicating the need for new therapies that target this high-risk subtype of AML.These results offer a potential molecular stratification and treatment guidance for patients with AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Nan Wang Fei Li Liping Dou Daihong Liu | 2024 | Cancer Pathogenesis and Therapy2024，2，2： | 0 |
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