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| 1 | 应用微型剪切试验评定焊接接头的力学性能显示文摘该文介绍一种研究金属材料机械性能的新型试验方法——微型剪切试验方法在焊接技术中的应用.该方法简单、省料、试验数据重现性好,尤其适用于定量测定不均匀材料各狭窄区域的性能参数或性能梯度.该文着重研究用微型剪切法评定CO_2焊接接头各区域性能,并将有关试验结果与常规Charpy冲击试验结果相比较.对上述两种方法的试验结果经过回归处理,表明剪切强度与Charpy冲击功之间有较好的对应关系.试验结果初步认为,可以通过微型剪切试验测定材料剪切强度来估算材料的冲击韧性. | 周丽霞 王士元 Lutz Dorn | 1993 | 西安交通大学学报1993，27，5： | 5 |
| 2 | American Gastroenterological Association Medical Position Statement on Constipation显示文摘 | Adil E. Bharucha Spencer D. Dorn Anthony Lembo Amanda Pressman | 2013 | Gastroenterology2013，，1： | 3 |
| 3 | Stem cell autotomy and niche interaction in different systems显示文摘The best known cases of cell autotomy are the formation of erythrocytes and thrombocytes(platelets) from progenitor cells that reside in special niches. Recently, autotomy of stem cells and its enigmatic interaction with the niche has been reported from male germline stem cells(GSCs) in several insect species. First described in lepidopterans, the silkmoth, followed by the gipsy moth and consecutively in hemipterans, foremost the milkweed bug. In both, moths and the milkweed bug, GSCs form finger-like projections toward the niche, the apical cells(homologs of the hub cells in Drosophila). Whereas in the milkweed bug the projection terminals remain at the surface of the niche cells, in the gipsy moth they protrude deeply into the singular niche cell. In both cases, the projections undergo serial retrograde fragmentation with progressing signs of autophagy. In the gipsy moth, the autotomized vesicles are phagocytized and digested by the niche cell. In the milkweed bug the autotomized vesicles accumulate at the niche surface and disintegrate. Autotomy and sprouting of new projections appears to occur continuously. The significance of the GSC-niche interactions, however, remains enigmatic. Our concept on the signaling relationship between stem cell-niche in general and GSC and niche(hub cells and cyst stem cells) in particular has been greatly shaped by Drosophila melanogaster. In comparing the interactions of GSCs with their niche in Drosophila with those in species exhibiting GSC autotomy it is obvious that additional or alternative modes of stem cell-niche communication exist. Thus, essential signaling pathways, including niche-stem cell adhesion(E-cadherin) and the direction of asymmetrical GSC division- as they were found in Drosophila- can hardly be translated into the systems where GSC autotomywas reported. It is shown here that the serial autotomy of GSC projections shows remarkable similarities with Wallerian axonal destruction, developmental axon pruning and dying-back degeneration in neurodegenerative diseases. Especially the hypothesis of an existing evolutionary conserved 'autodestruction program' in axons that might also be active in GSC projections appears attractive. Investigations on the underlying signaling pathways have to be carried out. There are two other well known cases of programmed cell autotomy: the enucleation of erythroblasts in the process of erythrocyte maturation and the segregation of thousands of thrombocytes(platelets) from one megakaryocyte. Both progenitor cell types- erythroblasts and megakaryocytes- are associated with a niche in the bone marrow, erythroblasts with a macrophage, which they surround, and the megakaryocytes with the endothelial cells of sinusoids and their extracellular matrix. Although the regulatory mechanisms may be specific in each case, there is one aspect that connects all described processes of programmed cell autotomy and neuronal autodestruction: apoptotic pathways play always a prominent role. Studies on the role of male GSC autotomy in stem cell-niche interaction have just started but are expected to reveal hitherto unknown ways of signal exchange. Spermatogenesis in mammals advance our understanding of insect spermatogenesis. Mammal and insect spermatogenesis share some broad principles, but a comparison of the signaling pathways is difficult. We have intimate knowledge from Drosophila, but of almost no other insect, and we have only limited knowledge from mammals. The discovery of stem cell autotomy as part of the interaction with the niche promises new general insights into the complicated stem cell-niche interdependence. | David C Dorn August Dorn | 2015 | World Journal of Stem Cells2015，7，6： | 3 |
| 4 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 5 | Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow显示文摘 | Ralf L Schild Christine Knobloch Christoph Dorn Rolf Fimmers Hans van der Ven Manfred Hansmann | 2001 | Fertility and Sterility2001，，2： | 2 |
| 6 | Determination of coefficients of friction for laminated veneer lumber on steel under high pressure loads显示文摘In this study,static coefficients of friction for laminated veneer lumber on steel surfaces were determined experimentally.The focus was on the frictional behaviors at different pressure levels,which were studied in combination with other influencing parameters:fiber orientation,moisture content,and surface roughness.Coefficients of friction were obtained as 0.10–0.30 for a smooth steel surface and as high as 0.80 for a rough steel surface.Pressure influenced the measured coefficients of friction,and lower normal pressures yielded higher coefficients.The influence of fiber angle was observed to be moderate,although clearly detectable,thereby resulting in a higher coefficient of friction when sliding perpendicular rather than parallel to the grain.Moist specimens contained higher coefficients of friction than oven-dry specimens.The results provide realistic values for practical applications,particularly for use as input parameters of numerical simulations where the role of friction is often wrongfully considered. | Michael DORN Karolína HABROVÁ Radek KOUBEK Erik SERRANO | 2021 | Friction2021，9，2： | 2 |
| 7 | Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support显示文摘 | Scot J. Matkovich Derek J. Van Booven Keith A. Youker Guillermo Torre-Amione Abhinav Diwan William H. Eschenbacher Lisa E. Dorn Mark A. Watson Kenneth B. Margulies Gerald W. Dorn | 2009 | Circulation2009，，： | 2 |
| 8 | MicroRNAs in heart disease : putative novel therapeutic targets? 显示文摘 | Condorelli G Latronico MV Dorn GW | 2010 | Eur Heart J2010，31，6： | 1 |
| 9 | Studies on nodal integral methods for the convec- tion-diffusion heat equation显示文摘 | MICHAEL E P E DORNING J J RIZWAN U | 2001 | Nuclear Science and Engineering2001，137，3： | 1 |
| 10 | The relationship be- tween motor proficiency and physical activity in children 显示文摘 | WROTNIAK BH EPSTEIN LH DORN JM | 2006 | Pediat- rics2006，118，6： | 1 |
| 11 | Recoil-ion and electron momentum spectroscopy:reaction-microscopes显示文摘 | ULLRICH J MOSHAMMER R DORN A | 2003 | Reports on Progress in Physics2003，66，9： | 1 |
| 12 | Costs of dairy cow diseases to producers in Ohio显示文摘 | Miller G Y Dorn C R | 1990 | Prev Vet Med1990，8，： | 1 |
| 13 | Host specificity and comparative foraging behaviour of Aenasius vexans and Acerophagus coccois, two endoparasitoids of the cassava mealybug显示文摘 | Dorn B Mattiacci L Bellotti A C et ol | 2001 | Entomologia Experimentalis et Applicata2001，99，3： | 1 |
| 14 | Experimental study of multiple steady states in homogeneous azeotropic distillation显示文摘 | Thomas E Gu1ttinger Cornelius Dorn Manfred Morari | 1997 | Ind Eng Chem Res1997，36，： | 1 |
| 15 | American Gastroenterological Association medical position statement on constipation显示文摘 | Bharucha AE Dorn SD | 2013 | Gastroenterology2013，144，6： | 1 |
| 16 | Induced emissions of apple fruit volatiles by the codling moth: changing patterns with different time periods after infestation and different larval instars显示文摘 | ALAN HERN SILVIA DORN | 2001 | Phytochemistry2001，57，： | 1 |
| 17 | Low and high adrenergic receptors differentially affect cardiac hypertrophy and function in Gaq overexpressing mice显示文摘 | DORN G W Ⅱ TEPE N M LORENZ J N | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 18 | Manipulating cardiac contractility in heart failure: Data from mice and men 显示文摘 | Dorn G Molkentin JD | 2004 | Circulation2004，109，2： | 1 |
| 19 | Response of Cydia pomonella to se- lection on mobility:laboratory evaluation and field verification 显示文摘 | Keil S Gu H N Dorn S | 2001 | Ecological Entomology2001，26，： | 1 |
| 20 | Tobacco consumption and mortality from cancer and other diseases 显示文摘 | Dorn HF | 1959 | Public Health Rep1959，74，7： | 1 |
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