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| 1 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 2 | Divergence of renal vascular endothelial growth factor mRNA expression and protein level in post- ischaemic rat kidneys 显示文摘 | Vannay A Fekete A dori C | 2004 | Experimental Physiology2004，89，4： | 1 |
| 3 | Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca 2+ signaling显示文摘 | Michael Kühl Karin Geis Laird C Sheldahl Tobias Pukrop Randall T Moon Doris Wedlich | 2001 | Mechanisms of Development2001，，1： | 1 |
| 4 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 5 | A Modular Software ProcessMini-Assessment Method显示文摘 | Karl E Wiegers Doris C Sturzenberger | 2000 | JEEE Software2000，2000，： | 1 |
| 6 | Hypoxia links ATR and p53 through replication Arrest显示文摘 | DENKO N C DORIE M J | 2002 | Mol Cell Biol2002，22，6： | 1 |
| 7 | Relation between macular morphology and visual function in patients with choroidal neovascularisation of age related macular degeneration显示文摘 | Doris N Hart PM Chakravarthy U McCleland J Stevenson M Hudson C | 2001 | Br J Ophthalmol2001，85，： | 1 |
| 8 | Development of a quantitative Real -Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs 显示文摘 | Marois C Dory D Fablet C | 2010 | J Appl Microbiol2010，108，5： | 1 |
| 9 | Identification of a Drosophila melanogaster glutamate - gated chloride channel sensitive to the antiparasitic agent avermec- tin显示文摘 | Doris F C | 1996 | J of biology chemistry1996，271，20： | 1 |
| 10 | Hepatitis B virus e antigen specific epitopes and limitations of commercial anti-HBe immunoassays显示文摘 | Mark AB Angelica MS Doris C | 2000 | J Med Virol2000，60，： | 1 |
| 11 | Blends of cross-linked high amylose starch/pectin loaded with diclofenac 显示文摘 | Grazielle A S Doris A C Beatriz S F C | 2013 | Carbohydrate Polymers2013，91，： | 1 |
| 12 | Sens Actuators B显示文摘 | Guidi V Cardinali G C Dori L | 1998 | 49(1-2):88-921998，49，12： | 1 |
| 13 | Development of a quantitative Real-Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs显示文摘 | Marois C Dory D Fablet C | | 0，，05： | 1 |
| 14 | Anaerobic capacity of elite taiwanese taekwondo athletes显示文摘 | LIN W L YEN K T LU C Y DORIS | 2006 | Sci Sports2006，21，12： | 1 |
| 15 | Self-transcendence and well-being in women with newly diagnosed breast cancer following a support group intervention显示文摘 | Doris C | 2004 | Oncol Nurs Forum2004，31，2： | 1 |
| 16 | Antibiotic prophylaxis in clean surgery : vascular surgery 显示文摘 | PRATESI C RUSSO D DORI W | 2001 | J Chemother2001，1，： | 1 |
| 17 | Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates显示文摘 | Anna C David B Doris H | 2001 | Toxicological Science2001，63，1： | 1 |
| 18 | Regioselective,Borinic Acid-Catalyzed Monoacylation,Sulfonylation and Alkylation of Diols and Carbohydrates:Expansion of Substrate Scope and Mechanistic Studies显示文摘 | Doris L Caitlin L W Lina C | 2012 | J Am Chem Soc2012，134，19： | 1 |
| 19 | Develop-ment of a quantitative Real-Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain116required to induce pneumo-nia in SPF pigs显示文摘 | MAROIS C DORY D FABLET C | 2010 | J Appl Microbiol2010，108，5： | 1 |
| 20 | Primary adenocarcinoma of the duodenum analysis of survival显示文摘 | Lai EC Dory JE Irving C | 1988 | World J Surg1988，12，： | 1 |
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