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| 1 | Formation mechanisms of megadunes and lakes in the Badain Jaran Desert,Inner Mongolia显示文摘Field observations demonstrate that calc-sinters occurred in the lakes of Badain Jaran Desert. 87Sr/86Sr ratios,14C,δ 13C and mineral com-positions of calc-sinters,and 3He/4He,4He/20Ne,δ 18O,δ D,pH and TDS of water from springs and lakes are analyzed in detail. The results indicate that the lake water is supplied through deep fault zone. The “ker-nel” of stabilized dunes in the Badain Jaran Desert perhaps consists of calc-sinters and calcareous ce-mentation layers. Deep-seated groundwater effuses from this “kernel” and recharges to lakes in desert. Precipitation and snowmelt water from the Qing-hai-Tibet Plateau is fed into the Badain Jaran Desert,Gurinai,Wentougaole and Ejinqi areas through the Xigaze-Langshan Fault zone. The isotopic composi-tions of groundwater in the Alax Plateau are abnor-mal due to the strong evaporation of the Gyaring and Ngoring lake water in the headstream of the Yellow River. Groundwater dissolves dissoluble fractions of rocks during its transportation through the fault zone and flows out of the mouth of spring in the Badan Jaran Desert. The dissoluble fractions are finally de-veloped into calc-sinters and calcareous cementation layers around the spring. Calci-sinters are gradually largened and eventually emerge on the surface of lake water. Eolian sands accumulate on the surfaces of calc-sinters and calcareous cementation layers,and eventually develop into dunes. Invasion of magma causes an increase in the temperature of groundwater within the faults. Groundwater evapora-tion provides water vapor for the formation of humid stabilized dunes during its upwelling. Rhizoconcre-tions found in Yihejigede indicate that the dune was formed and remained immovable 4700 years ago. The height of the megadunes is proportional to thermal quantity carried by the groundwater. | CHEN Jiansheng ZHAO Xia SHENG Xuefen DONG Haizhou RAO Wenbo SU Zhiguo | 2006 | Chinese Science Bulletin2006，51，24： | 19 |
| 2 | Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats显示文摘OBJECTIVE:To evaluate the effects of Xuebijing(XBJ) injection in heat stroke(HS) rats and to investigate the mechanisms underlying these effects.METHODS:Sixty anesthetized rats were randomized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ(XBJ group) or phosphate buffered saline(HS and Sham groups) per kg body weight.HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber(ambient temperature 40 ℃,humidity 60%).Rectal temperature,aterial pressure,and heart rate were monitored and recorded.Time to HS onset and survival were determined,and serum concentrations of tumor necrosis factor(TNF)-α,inRESULTS:Time to HS onset and survival were significantly longer in the XBJ than in the HS group.Moreover,the concentrations of TNF-α,IL-1β,IL-6,ALT and AST were lower and liver injury was milder in the XBJ than in the HS group.Heat-stress induced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α,IL-β and IL-6 secreted by KCs were lower in the XBJ than in the HS group.CONCLUSION:XBJ can alleviate HS-induced systemic inflammatory response syndrome and liver injury in rats,and improve outcomes.These protective effects may be due to the ability of XBJ to inhibit cytokine secretion by KCs. | Yi Chen Huasheng Tong Xingqin Zhang Liqun Tang Zhiguo Pan Zhifeng Liu Pengkai Duan Lei Su | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 14 |
| 3 | Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays显示文摘The coastal area of the East China Sea has experienced rapid urbanization and industrialization in China since 1980 s, resulting in severe pollution of its environments.Antibiotic resistance genes(ARGs) are regarded as a kind of emerging pollutant with potential high risk. The sediment samples were collected from Hangzhou Bay(HB),Xiangshan Bay(XB), and Taizhou Bay(TB) to investigate the spatial occurrence and distribution of 27 ARGs and class I integron–integrase gene(intI1) in the coastal area of the East China Sea. The PCR results showed the frequent presence of 11 ARGs and intI1 in the sediments of the three bays. The qPCR results further showed that sulfonamide resistance was the most prevalent ARG type and antibiotic target replacement and protection were the most important resistance mechanisms in the sediments. Regarding the subtype of ARGs, sulI, tetW, and dfrA13 were the most abundant ARGs, in which sulI was higher in TB(based on both the absolute and relative abundances) and dfrA13 was higher in HB(based on the relative abundances). The network analysis revealed that intI1 had significant correlations with tetC, sulI, sulII, and blaPSE-1. Oil was the key connected factor, which had positive connections with sulI, sulII, and blaPSE-1. In addition, the joint effect of heavy metals and nutrients & organic pollutants might be crucial for the fate of ARGs in the coastal sediments. | Jiayu Chen Zhiguo Su Tianjiao Dai Bei Huang Qinglin Mu Yongming Zhang Donghui Wen | 2019 | Journal of Environmental Sciences2019，31，7： | 13 |
| 4 | Chemical and Isotopic Approach to Groundwater Cycle in Western Qaidam Basin,China显示文摘Due to the extremely arid climate in the western Qaidam Basin,the groundwater almost becomes the single water source for local residents and industrial production.It is necessary to know the reliable information on the groundwater cycle in this region for reasonable and sustainable exploitation of the groundwater resources with the further execution of recycling economy policies.This study focused on the recharge,the flow rate and the discharge of groundwater in the western Qaidam Basin through investigations on water chemistry and isotopes.Hydrological,chemical and isotopic characteristics show that the groundwater in the western Qaidam Basin was recharged by meltwater from new surface snow and old bottom glaciers on the northern slope of the Kunlun Mountains.In addition,the results also prove that the source water is enough and stable,and the rates of the circulation and renewal of the groundwater are relatively quick.Therefore,it can be concluded that the groundwater resources would guarantee the regional requirement if the meltwater volume of the mountains has not a great changes in future,moreover,water exploitation should be limited to the renewable amount of the groundwater reservoir in the western Qaidam Basin. | TAN Hongbing RAO Wenbo CHEN Jiansheng SU Zhiguo SUN Xiaoxu LIU Xiaoyan | 2009 | Chinese Geographical Science2009，19，4： | 10 |
| 5 | Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro显示文摘Human umbilical cord blood was collected from full-term deliveries scheduled for cesarean section.Mononuclear cells were isolated,amplified and induced as mesenchymal stem cells.Isolated mesenchymal stem cells tested positive for the marker CD29,CD44 and CD105 and negative for typical hematopoietic and endothelial markers.Following treatment with neural induction medium containing brain-derived neurotrophic factor for 7 days,the adherent cells exhibited neuron-like cellular morphology.Immunohistochemical staining and reverse transcription-PCR revealed that the induced mesenchymal stem cells expressed the markers for neuron-specific enolase and neurofilament.The results demonstrated that human umbilical cord blood-derived mesenchymal stem cells can differentiate into neuron-like cells induced by brain-derived neurotrophic factor in vitro. | Lei Chen Zhongguo Zhang Bing Chen Xiaozhi Liu Zhenlin Liu Hongliang Liu Gang Li Zhiguo Su Junfei Wang Guozhen Hui | 2011 | Neural Regeneration Research2011，6，13： | 8 |
| 6 | Hybridization of metal–organic framework and monodisperse spherical silica for chromatographic separation of xylene isomers显示文摘Metal–organic frameworks(MOFs) packed in the column have been a promising candidate as the stationary phase for high performance liquid chromatography(HPLC). However, the direct packing of irregular MOF powder could raise some problems like high back pressure and low column efficiency in the HPLC separation. In this work, UiO-66 capable of separating xylenes was supported effectively on the surface of the monodisperse spherical silica microspheres by one-pot method. The hybridization of Ui O-66 and silica microspheres(termed UiO-66@SiO2 shell–core composite) was prepared by stirring the suspension of the precursors of Ui O-66 and\\COOH terminated silica in the N,N-dimethylformamide with heating. The shell–core composite material UiO66@SiO2 was characterized by SEM, TEM, PXRD and FTIR. Then, it was used as a packing material for the chromatographic separation of xylene isomers. Xylene isomers including o-xylene, m-xylene and p-xylene were efficiently separated on the column with high resolution and good reproducibility. Moreover, the Ui O-66@SiO2 shell–core composites packed column still remained reverse shape selectivity as Ui O-66 possessed, and the retention of xylenes was probably ascribed to the hydrophobic effect between analytes and the aromatic rings of the Ui O-66 shell. The Ui O-66@SiO2 shell–core composites obtained in this study have some potential for the separation of structural isomers in HPLC. | Bixuan Gao Minhui Huang Zhiguo Zhang Qiwei Yang Baogen Su Yiwen Yang Qilong Ren Zongbi Bao | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 4 |
| 7 | Study on the mechanism of isotope fractionation in soil water during the evaporation process under equilibrium condition显示文摘In this study, with the method of vacuum extraction, two evaporative processes of soil water and free water under equilibrium condition were simulated. For each sample,water vapor was condensed by liquid nitrogen and was collected in four time intervals. From the analysis of hydrogen and oxygen isotopic compositions of the water collected at different times, it was discovered that the isotope fractionation of soil water also follows the mode, which is just the same as the evaporative process of free water. The relationship between the stable hydrogen and oxygen isotopes in residual water showed that the simulative evaporation line was close to the global meteoric water line (GMWL) under the equilibrium condition at about 20℃. Comparison of the two types of evaporative processes indicated that the isotope fractionation and evaporation velocity of soil water were only slightly modified by the Van der Waals force. | SUN Xiaoxu CHEN Jiansheng TAN Hongbing RAO Wenbo WANG Yongsen LIU Xiaoyan SU Zhiguo | 2009 | Chinese Journal Of Geochemistry2009，28，4： | 4 |
| 8 | Separation and Purification of Thrombin-like Enzymes by Affinity Adsorbents显示文摘An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like enzyme-defibrase was used as a model in order to evaluate the efficiency of this biospecific affinity adsorbent. The homogeneity of the enzyme preparation was comfirmed as one band on sodium dodecyl sulfate polyacrylamide gel electrophoresis. | 杨青 Xu Xiaoming Hu Xuejun Gao Xiaorong Dong Xinyan Su Zhiguo An Lijia | 2001 | High Technology Letters2001，7，4： | 2 |
| 9 | Positional assembly of multi-enzyme cascade reaction in polyelectrolyte doped microcapsule through electrospray and layer-by-layer assembly显示文摘Polyelectrolyte-doped microcapsules(PDM)was fabricated by coaxial electrospray of a mixture of glycerol and water containing 10 mg/mL cationic polyelectrolyte poly(allylamine hydrochloride)(PAH)fed as the core phase solution,and a N,N-dimethylacetylamide solution of 10 wt%polyurethane fed as the shell phase solution.Multienzyme system involving Candida Antarctica lipase B(CALB),glucose oxidase(GOD),and horseradish peroxidase(HRP)for cascade reaction was assembled in the PDM at three different places,namely,surface,shell,and lumen.Placing of enzyme inside aqueous lumen of the PDM was realized by in situ encapsulation through adding the enzyme in the core-phase solution for coaxial electrospray.By ion-pairing of enzyme with cationic surfactant CTAB,an organic soluble enzyme-CTAB complex was prepared,so that in situ embedding of enzyme in the shell of the PDM was realized by adding it into the shell phase solution.Surface attachment of enzymes was achieved by layer-by-layer(LbL)technology,which is based on the ion-exchange interactions between oppositely charged enzymes and PAH that was doped in PDM.The enzyme-decorated microcapsule was then studied as a microbioreactor,in which 1-Oxododecyla-α-glucopyranoside was converted by CALB to glucose,which was oxidised by GOD to gluconolactone in a second step.The hydrogen peroxide produced was then used by HRP to oxidize ABTS to form coloured radical cation ABTS•+for activity analysis.The successful fabrication of the PDM and precise localization of enzymes in the PDM by different strategies were fully characterized.By varying the immobilization strategy,totally six PDM bioreactors with three enzymes precisely positional assembled in different strategies were constructed and their activities for the cascade reaction were investigated and compared.The PDM micro-bioreactor prepared by novel electrospray technologies provide a smart platform for positional assembly of multi-enzyme cascade reaction in a precise and well-controlled manner. | Shiyi Che Jie Wang Xiaoyuan Ji Zhiguo Su Shaomin Wang Songping Zhang | 2020 | Synthetic and Systems Biotechnology2020，5，3： | 2 |
| 10 | A new way of transformation from a-quartz to coesite显示文摘联合高精力的机械球 milling 和高静态的压力的一个实验室方法为在地球的外壳中为 caesite 的合成建模被建议了。milling 时间,石英的一个机械导致碰撞的中间的阶段和它容易在 3.0 GPa 的条件下面结晶进 coesite 的条件的一扇窗户, 923 K, <
1.0 min 被发现了。新方法比以前使用的那些需要许多更短的综合时间和更低的综合批评压力。为 coesite 的拉曼系列由现在的方法综合了论及以前报导的那些自然、综合的 coesites 的所有信息。这个方法在地球科学研究有一个大潜力,这被表明并且在地球的外壳中暗示了 coesite 形成的另外的可能的机制。 | SU Wenhui LIU Shue XU Dapeng WANG Weiran YAO Bin GUO Xingyuan LIU Zhiguo ZHONG Zheng | 2006 | Progress in Natural Science:Materials International2006，16，10： | 2 |
| 11 | Dual gradient ion-exchangechromatography improved refolding yield of lysozyme显示文摘 | Li Ming Zhang Guifeng Su Zhiguo | 2002 | Journalof Chromatography A2002，959，12： | 1 |
| 12 | 显示文摘 | Wu Jie Su Zhiguo Ma Guanghui | 2006 | International Journal of Pharmaceutics2006，315，12： | 1 |
| 13 | Efficient conversion of crop stalk wastes into succinic acid production by Actinobacillus succinogenes显示文摘 | Qiang Li Maohua Yang Dan Wang Wangliang Li Yong Wu Yunjian Zhang Jianmin Xing Zhiguo Su | 2009 | Bioresource Technology2009，，9： | 1 |
| 14 | Disuccinimidyl suberate cross-linked hemoglobin as a novel red blood cell substitute显示文摘Disuccinimidyl suberate (DSS) intramolecularly cross-linked hemoglobin (Hb) was developed as a novel red blood cell substitute. A multi-angle laser light scattering detector coupled with size exclusion HPLC was applied to determine the molecular weight of the modified Hb. SDS-PAGE was also used as a complement. It was proved that 83.8% of the product was intramolecularly cross-linked Hb with weight-average molecular weights (Mw) of 67.5 kD, 12% was dimeric Hb with Mw of 146.6 kD, and 4.2% was trimeric Hb with Mw of 306.4 kD. The tetramer structure of the cross-linked Hb was stable as shown in size-exclusion chromatography using a mobile phase containing 1 mol/L MgCl2. Analysis by LC-MS demonstrated that the reaction of DSS with Hb mainly took place between the twoα subunits within a Hb molecule, resulting in stabilization of the tetramer structure. However, the cross-linking was not site-specific. The P50 of the cross-linked Hb decreased from 21.8 mmHg to 14.3 mmHg, and the Hill coefficient decreased from 2.22 to 1.41. Result of isoelectric focusing showed that the pI of DSS cross-linked Hb was in the range of 4.6-5.2, similar to that of serum albumin. The safety of DSS cross-linked Hb was favored by animal tests on rats and guinea pigs. Exchange transfusion experiment with DSS cross-linked Hb using rats as a model indicated no pressor effect or other significant side effects. The characteristics and properties of DSS cross-linked Hb were also compared with that of diaspirin cross-linked Hb reported in the literature. | LU Xiuling, ZHENG Chunyang, XU Yuhong & SU Zhiguo National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China School of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China | 2005 | Science China(Life Sciences)2005，48，1： | 1 |
| 15 | Cloning and expression of defibrase cDNA from the venom of Gloydius shedaoensis * *显示文摘 | Qing Yang Xiaoming Xu Min Li Xiaodong Yuan Zhiguo Su Jan-Christer Janson Lijia An | 2002 | Biotechnology Letters2002，，2： | 1 |
| 16 | Comparison of high-speed counter-current chromatography and high-performance liquid chromatography on fingerprinting of Chinese traditional medicine显示文摘 | MING GU FAN OUYANG ZHIGUO SU | 2004 | J Chromat A2004，1022，： | 1 |
| 17 | Effects of local mechanical collision with shear stress on the phase transformation from α-quartz to coesite induced by high static pressure显示文摘 | Su Wenhui Liu Shu' e Xu Dapeng Wang Weiran Yao Bin Liu Xiaomei Liu Zhiguo and Zhong Zheng | | 0，，： | 1 |
| 18 | A new way of transformation from alpha-quartz to coesite显示文摘 | Su Wenhui Liu Shu' e Xu Dapeng Wang Weiran) Yao Bin Guo Xingyuan Liu Zhiguo Zhong Zheng | | 0，，10： | 1 |
| 19 | Fluid Mobility Evaluation of Tight Sandstones in Chang 7 Member of Yanchang Formation, Ordos Basin显示文摘Fluid mobility has been important topic for unconventional reservoir evaluation.The tight sandstones in Chang 7 Member of the Ordos Basin has been selected to investigate the fluid mobility based on the application of core flooding-NMR combined method and core centrifugation-NMR combined method,and the porous structure is studied using optical microscope,field emission scanning electron microscope(FE-SEM),CT and mercury injection.Our results include:(i)Feldsparrock fragments dissolution pores,calcite dissolution pores,clay mineral dissolution pores,intergranular dissolution expansion pores,inter-granular pores,intra-kaolinite pores,and intra-illite/smectite mixed layer pores are developed in Chang 7 tight sandstones;3D CT pore structure shows that the pore connectivity is positively related to physical properties,and the overall storage space is connected by the throat with diameter between 0.2 and 0.3μm.The percentage of storage space connected by throats with diameter less than 100 nm can reach more than 35%.(ii)Movable fluid saturation of Chang 7 tight sandstones is between 10%and 70%,and movable oil saturation is between 10%and 50%.Movable fluid saturation may cause misunderstanding when used to evaluate fluid mobility,so it is recommended to use movable fluid porosity in the evaluation of fluid mobility.The porosity ranging from 5%to 8%is the inflection point of the fluidity and pore structure.For samples with porosity less than 8%,the movable fluid porosity is generally less than 5%.Moreover,the movable fluid is mainly concentrated in the storage space with a throat diameter of 0.1 to 1μm.For samples with porosity greater than 8%,the porosity of the movable fluid is more than 5%,and the movable fluid is mainly concentrated in the storage space with a throat diameter of 0.2 to 2μm.(iii)The movable fluid saturation measured by core flooding-NMR combined method is generally higher than that measured by core centrifugation-NMR combined method.The former can evaluate the mobility of the oil-water two-phase fluid in samples,while the latter can better reflect the pore structure and directly evaluate the movable fluid in the pore system controlled by different throat diameters.All these results will provide valuable reference for fluid mobility evaluation in tight reservoirs. | Songtao Wu Shixiang Li Xuanjun Yuan Zhi Yang Aifen Li Jingwei Cui Songqi Pan Zhiguo Mao Ling Su You Zhou | 2021 | Journal of Earth Science2021，32，4： | 1 |
| 20 | In vitro protein refolding by chromatographic procedures显示文摘 | LI Ming SU Zhiguo JANSON J C | 2004 | Protein Expr Puri2004，33，1： | 1 |
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