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| 1 | Early diabetic neuropathy:Triggers and mechanisms显示文摘Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the most frequent and troublesome complications of diabetes mellitus. It is the major reason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presenta- tions of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glu- cose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has ac- cumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, cor- relation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our un- derstanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on clinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia. | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | World Journal of Gastroenterology2007,13,2: | 55 |
| 2 | Understanding important features of deep learning models for segmentation of high-resolution transmission electron microscopy images显示文摘Cutting edge deep learning techniques allow for image segmentation with great speed and accuracy.However,application to problems in materials science is often difficult since these complex models may have difficultly learning meaningful image features that would enable extension to new datasets.In situ electron microscopy provides a clear platform for utilizing automated image analysis.In this work,we consider the case of studying coarsening dynamics in supported nanoparticles,which is important for understanding,for example,the degradation of industrial catalysts.By systematically studying dataset preparation,neural network architecture,and accuracy evaluation,we describe important considerations in applying deep learning to physical applications,where generalizable and convincing models are required.With a focus on unique challenges that arise in high-resolution images,we propose methods for optimizing performance of image segmentation using convolutional neural networks,critically examining the application of complex deep learning models in favor of motivating intentional process design. | James P.Horwath Dmitri N.Zakharov Rémi Mégret Eric A.Stach | 2020 | npj Computational Materials2020,,1: | 8 |
| 3 | 早期糖尿病神经病变:病因与机制显示文摘外周神经病变,尤其是末梢神经病变,是糖尿病最常见而棘手的并发症之一。它是糖尿病患者发病与死亡的主要原因,还常与衰弱性疼痛相关。遗憾的是,我们对糖尿病末梢神经病变自然史与发病机理的了解仍然有限。本文介绍2007年1月《World J Gastroenterol》杂志上有关该病的早期病因与机制。 | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | 继续医学教育2007,21,5: | 1 |
| 4 | Peak-end rule versus average utility:How utility aggregation affects evaluations of experiences显示文摘 | Cojuharenco I Dmitry R | | 0,,05: | 1 |
| 5 | Resilience and mental health 显示文摘 | Dmitry M Davydov Stewart R | 2010 | Clin Psychol Rev2010,30,1: | 1 |
| 6 | A molecu lar dynamics simulation study of elastic properties of HMX显示文摘 | Sewell T D Menikoff R Dmitry B | 2003 | J Chem Phys2003,119,14: | 1 |
| 7 | Nonliththographic nano-wire arrays:fabrication, physics,and device applications显示文摘 | Dmitri R Tager A A Junji H | 1996 | IEEE Transactions on Electron Devices1996,43,10: | 1 |
| 8 | The effect of rapid thermal processing (RTP) on TiN coatings deposited by PVD and the steel-turning performance of coated cemen- ted carbide 显示文摘 | Anthoy J Perry J N Steve J Bull Dmitri I P Peter C R Trevor F P Daniel E G James T John J V Robert E D Vladinmir R Alexey B M | 1999 | Surface and Coatings Technology1999,120,121: | 1 |
| 9 | The optimal sorting of players in contests between groups显示文摘 | Dmitry R | 2011 | Games and Economic Behavior2011,73,2: | 1 |
| 10 | Contests with doping显示文摘 | DMITRY R | 2013 | Joumal of Sports Economics2013,14,3: | 1 |
| 11 | Optimal sorting in group contests with complementarities显示文摘 | Philip B Lightle J P Dmitry R | 2015 | Journal of Economic Behavior & Organization2015,,: | 1 |
| 12 | The missing memristor found显示文摘 | Dmitri B Strukov Gregory S Snider Duncan R Stewart | | 0,,7191: | 1 |
| 13 | The importance of wax-deposition measurements in the simulation and design of subsea pipelines显示文摘 | KAMRAN A JOHN R J DMITRY E | 2010 | SPE Projects Facilities & Construction2010,5,2: | 1 |
| 14 | In vivo calcium imaging of circuit activity in cerebellar cortex显示文摘 | Megan R Sullivan Axel Nimmerjahn Dmitry V Sarkisov | | 0,,02: | 1 |
| 15 | The path to 'single-component composites':An in situ X-ray study of melting and crystallization of extended-chain polyethylene fibers under pressure显示文摘 | LIRON S H DMITRY M R RAFAIL K | 2005 | Nucl Instrum Methods Phys Res B2005,238,: | 1 |
| 16 | Halloysite Clay Nanotubes for Controlled Release of Protective Agents 显示文摘 | Yuri M L Dmitry G Helmuth M Ronald R P | 2008 | Acs Nano2008,2,5: | 1 |
| 17 | Automatic discovery of similarity relationships through Web mining显示文摘 | Dmitri R Leon Z J | 2003 | Decision Support Systems2003,35,1: | 1 |
| 18 | Ti and Si doping as a way to increase low temperature activity of sulfated Ag/Al 2 O 3 in H 2 -assisted NH 3 -SCR of NO x显示文摘 | Dmitry E. Doronkin Sebastian Fogel P?r Gabrielsson Jan-Dierk Grunwaldt S?ren Dahl | 2014 | Applied Catalysis B: Environmental2014,,: | 1 |
| 19 | Microcoil embolization for acute lower gastrointestinal bleeding显示文摘 | Bertrand J Padmaja S Dmitry R | 2006 | Cardiovasc Intervent Radiol2006,29,: | 1 |
| 20 | 显示文摘 | DMITRI Y B BRIAN Y C WILLIAM R H | 2002 | J Chromatogr B2002,,: | 1 |