|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of Astragaloside Ⅳ Derivative on Heart Failure in Rats显示文摘Objective Astragaloside Ⅳ derivative(ASId) is one of Astragaloside Ⅳ(ASI) derivatives with higher water-solubility and may have more druggability than ASI.The present study aims at observing the effects of ASId on cardiovascular parameters in chronic heart failure in rats.Methods Using echocardiographic and haemodynamic measurements,the effects of ASId on congestive heart failure(CHF) induced by ligation of the left coronary artery in rats were investigated.Results ASId iv 0.5,1.0,and 2.0 mg/(kg·d) attenuated the decline of ejection fraction.The peak derivatives of the left ventricle(LV) pressure(dp/dt) in ASId treated groups were significantly increased.Both LV volumes in diastole and in systole were decreased significantly after ASId treatment,accompanied with a trend towards normalization of relative wall thickness at end-systole.ASId 0.5,1.0,and 2.0 mg/(kg·d) attenuated the increase of LV systolic and diastolic wall stress.ASId treatment also inhibited compensatory hypertrophy of depressed heart.Conclusion ASId could improve cardiac functions and inhibite compensatory hypertrophy and LV remodelling,which suggests the possibility of ASId as a new therapeutic drug for the treatment of CHF. | WANG Wei-ting1,ZHAO Zhuan-you1,HAN Ying-mei2,XU Wei-ren2,TANG Li-da1 1.State Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.Tianjin Key Laboratory of Molecular Design & Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China | 2010 | Chinese Herbal Medicines2010，2，1： | 13 |
| 2 | Separation,identification,and quantification of active constituents in Fructus Psoraleae by high-performance liquid chromatography with UV,ion trap mass spectrometry,and electrochemical detection显示文摘The qualitative and quantitative analysis of active constituents in Fructus Psoraleae is presented by high-performance liquid chromatography (HPLC) coupled with different detections.Extracts of Fructus Psoraleae were examined by HPLC with ion trap mass spectrometry (IT-MS) and 18 major compounds of coumarins,benzofuran glycosides,flavonoids,and meroterpene were identified.The determination of four major constituents including bavachin,isobavachalcone,bavachinin,and bakuchiol was accomplished by HPLC with UV,MS,and electrochemical detection (ECD).These methods were evaluated for a number of validation characteristics (repeatability,LOD,calibration range,and recovery).ECD obtained a high sensitivity for analysis of the four components;MS provided a high selectivity and sensitivity for determination of bavachin,isobavachalcone,and bavachinin in negative-ion mode.After optimization of the methods,separation,identification.and quantification of the four components in Fructus Psoraleae were comprehensively tested by HPLC with UV,MS,and ECD. | Qinhua Chen,Yuan Li,Zilin Chen Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University),Ministry of Education,and Wuhan University School of Pharmaceutical Sciences,Wuhan,430071,China | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 7 |
| 3 | A New Triterpene Saponin from Gynostemma pentaphyllum显示文摘Objective To study the triterpene saponins from Gynostemma pentaphyllum with antitumor activities. Methods The 75% EtOH extract of G. pentaphyllum was used for isolation by silica gel column chromatography and preparative HPLC. The structures of pure compounds isolated were identified by the spectral analysis and chemical evidence. Results Two compounds were isolated and identified as 23(S)-3β,20ξ,21ξ-trihydroxy-19-oxo-21,23-epoxydammar-24-ene 3-O-α-L-rhamnopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-arabinopyranoside (1) and 23(S)-21(R)-O-n-butyl-3β,20ξ-dihydroxy-21,23-epoxydammar-24-ene 3-O-α-L-rhamnopyranosyl (1→2)-[β-D-xylo- pyranosyl (1→3)]-β-D-arabinopyranoside (2). Conclusion Compound 2 is a new triterpene saponin with moderate antitumor activities against the HL-60, Colon205, and Du145 cell lines. | SHI Lin1, CAO Jia-qing2, ZHAO Hong3, ZHAO Yu-qing2, 4 1. College of Food Science, Shenyang Agriculture University, Shenyang 110161, China 2. School of Traditional Chinese Materia Madica, Shenyang Pharmaceutical University, Shenyang 110016, China 3. Dalian University, Dalian 116622, China 4. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China | 2010 | Chinese Herbal Medicines2010，2，4： | 7 |
| 4 | Virtual Evaluation on the Activities of Phthalides and Terpenoids from Angelica sinensis显示文摘Objective To elucidate potential activities of phthalides and terpenoids from Angelica sinensis by theoretical docking calculation. Methods Eleven components of phthalides and terpenoids were selected as ligand. The crystalline structures of targets related to common diseases were used as the receptors for calculation. The calculations were conducted with Schr?dinger software package. The grading standard of selectivity was developed according to G-score between ligands and receptors. Results Selective targets of phthalides and terpenoids were related to nevous system diseases, cancer, pain, diabetes, cardiovascular disease, liver cirrhosis, nephrotic syndrome, inflammatory diseases, rheumatoid arthritis, dermatosis, leukemia, microbial inflections, immune diseases, and hypercholesterolemia. In addition to the medical treatments reported in the literature, our research also indicated that these two classes of compounds may be used for tumor, diabetes, rheumatoid arthritis, dermatosis, leukemia, liver cirrhosis, and nephrotic syndrome. According to our research, the effects of phthalides and terpenoids may be not so strong. Conclusion The effects of phthalides and terpenoids on diseases founded through virtual evaluation accord greatly with those reported in experiment and clinic. The combination of computer-aided drug evaluation technique and experiment is definitely an important and fast way to investigate the effects and mechanisms of traditional Chinese medicine. | PEI Yuan1,2, TAN Chu-bing1, XU Wei-ren1, LIU Peng1, LIU Bing-ni1, LIU Wei1, CHEN Cheng-lung3, TANG Li-da1 1. Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 2. Basic Medical College, Tianjin Medical University, Tianjin 300070, China 3. Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, China | 2010 | Chinese Herbal Medicines2010，2，3： | 6 |
| 5 | Smashing Tissue Extraction and GC Analysis of Active Fatty Acids from Oil Cake of Perilla Seeds显示文摘Objective To optimize the extraction technology of perilla seeds oil from the oil cake of perilla seeds(OCPS)by using the contents of active fatty acids as evaluation standard.Methods The fatty acids were extracted from OCPS,the residue of perilla seeds after cold-press,by smashing tissue extraction(STE),the new technology selected through comparing with classical leaching extraction(LE),Soxhlet extraction(SE),ultrasonic extraction(UE),and supercritical-CO2 fluid extraction(SFE).For optimized condition of STE,orthogonal test was designed and completed.The contents of five fatty acids in extracted oil and OCPS were determined by GC.Results The optimized extraction parameters were smashing for 1.5 min under extraction power of 150 W and 1:6 of the material/solvent ratio.The contents of five fatty acids in the oils extracted by five techniques from OCPS and determined by GC were as follows:α-linolenic acid(41.12%-51.81%),linoleic acid(15.38%-16.43%),oleic acid (18.93%-27.28%),stearic acid(2.56%-4.01%),and palmitic acid(7.38%-10.77%).Conclusion The results show that STE is the most efficient technology with the highest yield(LE:0.57%;SE:1.03%;UE:0.61%;SFE:0.80%;STE: 1.17%)and shortest time(LE:720 min;SE:360 min;UE:30 min;SFE:120 min;STE:1.5 min)among five tested extraction technologies.It is first reported using STE to extract herbal oil enriched with active fatty acids. | SUN Yan-ling1,LIU Yan-ze2,3,XIAO Han4,WEI Ying-feng4,ZHAO Yu-qing1,5 1.Shenyang Pharmaceutical University,Shenyang 110006,China 2.Bio-organic and Natural Product Laboratory,MRC 311,McLean Hospital/Harvard Medical School,Belmont,MA 02478,USA 3.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 4.Liaoning Jiashi Nutritional Plant Oil Development Co.Ltd.,Shenyang 110035,China 5.Key Laboratory of Structure-Based Drug Design&Discovery,Shenyang Pharmaceutical University,Ministry of Education,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，1： | 5 |
| 6 | Smashing Tissue Extraction and HPLC Determination of Paclitaxel and 10-Deacetylbaccatin from Taxus x media显示文摘Objective To optimize the extraction technology of Taxus x media by using the contents of Paclitaxel and 10-deacetylbaccatin(10-DAB) ,two representative active diterpene alkaloids of taxane type from T.x media,as evaluation standard.Methods The smashing tissue extraction(STE) of Paclitaxel and 10-DAB from T.x media,was investigated by comparing with ultrasonic extraction(UE) which was one of the modern technologies of extraction.Results STE was more efficient than UE,and the contents of 10-DAB and Paclitaxel in the extracts obtained by STE were higher than those by UE.Conclusion STE is a fast,high-performance,and energy-saving technology for the extraction of diterpene alkaloids of taxane type.STE also provides a simple,component-safe,workable,and highly efficient method for the extraction of active natural product. | LIU Yan-ze1,2,GAO Wen-qin3,WANG Ji-wen4,ZHANG Yu3,ZHAO Yu-qing4,5 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 2.Bio-Organic and Natural Product Laboratory,McLean Hospital/Harvard Medical School,MA 02478,USA 3.Shenyang Pharmaceutical University,Shenyang 110006,China 4.Shenyang Tianfeng Bioengineer Technology Co.,Ltd.,Shenyang 110015,China 5.Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，3： | 4 |
| 7 | Editor’s note显示文摘In recent years, driven by ever-increasing market demand in computing, communication, and multimedia applications, the microelectronics industry has undergone rapid development. Because of technical innovation and advances in almost all aspects of materials, processes, equipment, devices, circuits and systems, siliconbased logic and memory IC technologies using nano-scaling continue to be the industry's major R&D focus. This maintains microelectronics industry adherence to the traditional 'Moore's Law', increasing the | HUANG Ru, Guest Editor Peking University Beijing 100871, China ZHAO Bin, Guest Editor Fairchild Semiconductor 32 Discovery, Irvine, CA 92618, USA WANG RunSheng, Guest Editor Assistant CAI YiMao, Guest Editor Assistant Peking University Beijing 100871, China | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 8 | Virtual Evaluation on Activities of Flavonoids from Scutellaria baicalensis显示文摘Objective To explore the investigation method of complicated and profound traditional Chinese herbal medicine,the potential action mechanisms of flavonoids from Scutellaria baicalensis were studied by docking calculation.Methods In total,eight flavonoids(aglycones and their glicosides) from S.baicalensis were selected as ligands.The crystalline structures of targets related to common diseases were used as the receptors for calculation.The calculations were conducted with Schrdinger software package.The grading standard of selectivity was developed according to G-score between ligands and receptors.Results Twenty-six pharmacologic actions have been reported.Among all effects in literature,nine of them can be deduced from the docking calculation of aglycone.From glycosides with grade ++,25 reported effects can be estimated by calculation.Apparently,the target selectivity of aglycones and their glycosides are different form the virtual evaluation.The virtual evaluation results of glycosides were closer to the reported effects.Conclusion Our proposed virtual evaluation method seems an effective way to investigate the complicated system of traditional Chinese herbal medicine.It suggests that aglycones may be effective as the form of glucoside in vivo,and metabolism is a very important factor for virtual evaluation. | SHANG Qian1,2,LIU Wei2,XU Wei-ren2,LIU Peng2,HAN Ying-mei2,CHEN Cheng-lung3,TANG Li-da2 1.Basic Medical College,Tianjin Medical University,Tianjin 300070,China 2.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 3.Department of Chemistry,National Sun Yat-sen University,Kaohsiung 80424,China | 2010 | Chinese Herbal Medicines2010，2，2： | 3 |
| 9 | New developments in small molecular compounds for anti-hepatitis C virus(HCV) therapy显示文摘Infection with hepatitis C virus(HCV) affects approximately 170 million people worldwide.However,no vaccine or immunoglobulin is currently available for the prevention of HCV infection.The standard of care(SOC) involving pegylated interferon-α(PEG-IFN α) plus ribavirin(RBV) for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis C genotype 1,the most prevalent type of HCV in North America and Europe.Recently,reliable in vitro culture systems have been developed for accelerating antiviral therapy research,and many new specifically targeted antiviral therapies for hepatitis C(STAT-C) and treatment strategies are being evaluated in clinical trials.These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration.The aim of this review is to summarize the current developments in new anti-HCV drugs. | Jing TONG1,2,You-wei WANG2,Yuan-an LU1,2(1Department of Public Health Sciences,University of Hawaii,Honolulu,Hawaii 96822,USA)(2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Institute of Traditional Chinese Medicine & Natural Products,School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071,China) | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 2 |
| 10 | Analgesic and Anti-inflammatory Effects of Ginger Oil显示文摘Objective Ginger(Zingiber officinale) is widely used as a spice in cooking and as a medicinal herb in traditional herbal medicine.The present study was to investigate the analgesic and anti-inflammatory activities of ginger oil in experimental animal models.Methods The analgesic effect of the oils was evaluated by the 'acetic acid' and 'hot-plate' test models of pain in mice.The anti-inflammatory effect of the oil was investigated in rats,using rat paw edema induced by carrageenan,adjuvant arthritis,and vascular permeability induced by bradykinin,arachidonic acid,and histamine.Indomethacin(1 mg/kg),Aspirin(0.5 g/kg) and Dexamethasone(2.5 mg/kg) were used respectively as reference drugs for comparison.Results The ginger oil(0.25-1.0 g/kg) produced significant analgesic effect against chemically-and thermally-induced nociceptive pain stimuli in mice(P < 0.05,0.01).And the ginger oil(0.25-1.0 g/kg) also significantly inhibited carrageenan-induced paw edema,adjuvant arthritis,and inflammatory mediators-induced vascular permeability in rats(P < 0.05,0.001).Conclusion These findings confirm that the ginger oil can be used to treat pain and chronic inflammation such as rheumatic arthritis. | JIA Yong-liang1,ZHAO Jun-ming2,ZHANG Lin-hui1,SUN Bao-shan2,BAO Meng-jing1,LI Fen-fen1,SHEN Jian1,SHEN Hui-jun1,ZHAO Yu-qing3,4,XIE Qiang-min11.Department of Pharmacology,Medical College of Zhejiang University,Hangzhou 310031,China 2.Liaoning Xinzhong Modern Medicine Co.,Ltd.,Shenyang 110041,China 3.College of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China 4.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China | 2011 | Chinese Herbal Medicines2011，3，2： | 2 |
| 11 | 显示文摘 | Adrian Burton Andrew Treloar Deputy Directors Australian NationalData Service Designing for Discovery and Re-Use: the 4ANDS DataSharing Verbs’ Abroach to Service Deconqjosition | 2009 | The InternationalJournal of Digital2009，2009，3： | 1 |
| 12 | Tumor Homing Peptides as Molecular Probes for Cancer Therapeutics, Diagnostics and Theranostics显示文摘 | A. Gautam P. Kapoor K. Chaudhary R. Kumar Open Source Drug Discovery Consortium G.P.S. Raghava | 2014 | Current Medicinal Chemistry2014，，21： | 1 |
| 13 | 7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models 显示文摘 | Yang S Xiao Y Kang D Liu J Li Y Undheim EA et aL Discovery of a selective Nav1 | 2013 | Proc Natl Acad Sci USA2013，110，43： | 1 |
| 14 | A- chieving lipid goals in real Life: the Dutch DISCOVERY study 显示文摘 | Bots AF Kastelein J J Discovery Netherlands Investigators | 2005 | lnt J Clin Pract2005，59，12： | 1 |
| 15 | Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation显示文摘 | Kastelein R Hunter C Discovery DC | 2007 | Immunology2007，25，： | 1 |
| 16 | A genome-wide linkage and association scan reveals novel loci for autism 显示文摘 | Weiss L A Arking D E Gene Discovery Project of Johns Hopkins & the Autism Consortium | 2009 | Nature2009，461，7265： | 1 |
| 17 | Sonoluminescence and cold fusion显示文摘Sonoluminescenceandcoldfusion￥TVPrevenslik(2EGreeneryCourt,DiscoveryBay,HongKong)Abstract:Atheoryofsonoluminescence(SL)propos... | T V Prevenslik(2E Greenery Court, Discovery Bay, Hong Kong) | 1996 | Nuclear Science and Techniques1996，7，1： | 1 |
| 18 | ARoughSet Ap- Classification Rules in Spa- tial Data 显示文摘 | Fung T Mi J proach to The Discovery of S etc | 2007 | International Journal of Geographical In- formation Science2007，21，9： | 1 |
| 19 | Biology and therapeutic po- tential of RNA interference, microRNA and antagomirs 显示文摘 | Yang M Mattes J Discovery | 2008 | Pharmacol Ther2008，117，： | 1 |
| 20 | Search strategies for biotechnology and the paradigm shift显示文摘 | Bull AT discovery Ward AC Goodfellow M | 2000 | Microbiology and Molecular Biology Reviews2000，64，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员