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| 1 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 2 | Adaptive fire- fly algorithm: parameter analysis and its application显示文摘 | Cheung N J Ding Xueming Shen Hongbin | 2014 | PLoS ONE2014，9，11： | 1 |
| 3 | Targeted delivery of doxorubicin using stealth liposomes modified with transferrin显示文摘 | Li Xueming Ding Liyan Xu Yuanlong | 2009 | Intern J Pharmaceut2009，373，12： | 1 |
| 4 | Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells显示文摘 | Yongguo Shi Jianwei Lu Jing Zhou Xueming Tan Ye He Jie Ding Yun Tian Li Wang Keming Wang | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 5 | Parameter estimation of takagi-suge-no fuzzy systemusing heterogeneous cuckoo search algorithm 显示文摘 | Ding Xueming Xu Zhenkai Ngaam J Cheung | 2015 | Neurocomputing2015，，151： | 1 |
| 6 | The influence of alumina dopant on the structural transformation of gel-derived nanometre titania powders显示文摘 | DING Xingzhao LIU Lin MA Xueming | 1994 | Journal of Materials Science Letters1994，13，6： | 1 |
| 7 | Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis显示文摘Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord injury.However,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains unclear.In the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem cells.We found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial scars.In addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway.These results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord injury.Therefore,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury. | Tao Liu Ziqian Ma Liang Liu Yilun Pei Qichao Wu Songjie Xu Yadong Liu Nan Ding Yun Guan Yan Zhang Xueming Chen | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 8 | Robust visual tracking for manipulators withunknown intrinsic and extrinsic parameters显示文摘This paper addresses the robust visual tracking of multi-feature points for a 3D manipulator with unknown intrinsic and extrinsic parameters of the vision system.This class of control systems are highly nonlinear control systems characterized as time-varying and strong coupling in states and unknown parameters.It is first pointed out that not only is the Jacobian image matrix nonsingular,but also its minimum singular value has a positive limit.This provides the foundation of kinematics and dynamics control of manipulators with visual feedback.Second,the Euler angle expressed rotation transformation is employed to estimate a subspace of the parameter space of the vision system.Based on the two results above,and arbitrarily chosen parameters in this subspace,the tracking controllers are proposed so that the image errors can be made as small as desired so long as the control gain is allowed to be large.The controller does not use visual velocity to achieve high and robust performance with low sampling rate of the vision system.The obtained results are proved by Lyapunov direct method.Experiments are included to demonstrate the effectiveness of the proposed controller. | Chaoli WANG Xueming DING | 2007 | 控制理论与应用(英文版)2007，5，4： | 0 |
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