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| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 4 | Dynamic PET reconstruction using wavelet regularization with adapted basis functions显示文摘 | Jeroen V Dimitri V D V | 2008 | IEEE Transaction on Medical Imaging2008，27，7： | 1 |
| 5 | Life-cycle cost analysis of reinforced concrete structures in marine environments显示文摘 | Dimitri V Val Mark G Stewart | 2003 | Structural Safety2003，25，： | 1 |
| 6 | Factors Affecting Life-Cycle Cost Analysis of RC Structures in Chloride Contaminated Environments 显示文摘 | Dimitri V | 2007 | Journal of Infrastructure Systems ASCE2007，13，2： | 1 |
| 7 | Reliability evaluation in analysis of reinforced concrete structures显示文摘 | Dimitri V et | 1997 | Structural Safety1997，19，2： | 1 |
| 8 | Doubleblind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering显示文摘 | Singh P Dimitriou V Mahajan RP | 1993 | Br J Anaesth1993，71，： | 1 |
| 9 | Real-time ultrasound-guided subclavian vein cannulation versus the landmark method in critical care patients:a prospective randomized study显示文摘 | Fragou M Gravvanis A Dimitriou V | | 0，，07： | 1 |
| 10 | Genetic variants associated with susceptibility to mother-to-child transmission of hepatitis B virus显示文摘 | Chatzidaki V Choumerianou D Dimitriou H | 2012 | Eur J Gastroenterol Hepatol2012，24，10： | 1 |
| 11 | Early prediction of chronic oxygen dependency by lung function test results 显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Pediatr Pulmonol2000，29，1： | 1 |
| 12 | Discovery and develop-merit of BMP显示文摘 | Dimitriou R Giannoudis P V | 2005 | Injury2005，31，7： | 1 |
| 13 | Current coneepts of molecular as Peets of bone healing显示文摘 | Dimitriou R Tsiridis E Giannoudis P V | | 0，，12： | 1 |
| 14 | Role of load history in reliability-based decision analysis of aging bridges显示文摘 | Mark G Stewart Dimitri V Val | 1999 | Journal of Structural Engineering1999，125，7： | 1 |
| 15 | Production of hydrogen for fuel cell by steam reforming of ethanol over supported noble metal catalysts显示文摘 | DIMITRIS K XENOPHON E V | 2003 | Applied Catalysis B:Environmental2003，43，： | 1 |
| 16 | Role of load history in reliability-based decision analysis of aging bridge显示文摘 | Mark G Stewart Dimitri V Val | 1999 | Journal of Structural Engineering1999，125，7： | 1 |
| 17 | Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes显示文摘 | Dimitris S Sophie Le P Ire'ne V | 2001 | The Journal of Immunology2001，166，2： | 1 |
| 18 | Selective methanation of CO over supported noble metal catalysts : Effects of the nature of the metallic phase on catalytic performance 显示文摘 | Paraskevi P Dimitris I K Xenophon E V | 2008 | Applied Catalysis A: General2008，344，12： | 1 |
| 19 | The PAxpress is an ef-fective ventilatory device but has an 18% failure rate forflexible lightwand-guided tracheal intubation in anesthe-tized paralyzed patients 显示文摘 | Dimitriou V Voyagis GS Iatrou C | 2003 | Can J Anaesth2003，50，5： | 1 |
| 20 | Why is fresh self- compacting concrete shear thickening? 显示文摘 | Dimitri F Ronny V Schutter G D | 2009 | Cement and Concerete Research2009，39，6： | 1 |
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