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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | Nonlinear path-following control of an AUV显示文摘 | Lionel Lapierre Didik Soetanto | 2007 | Ocean Engineering2007，，11： | 2 |
| 3 | Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission显示文摘 | Hanggoro Tri Rinonce Yoshihiko Yano Takako Utsumi Didik Setyo Heriyanto Nungki Anggorowati Dewiyani Indah Widasari Maria Inge Lusida Soetjipto Heru Prasanto Hak Hotta Yoshitake Hayashi | 2013 | J. Med. Virol2013，，8： | 1 |
| 4 | Clinical and virological characteristics of hepatitis B or C virus co‐infection with HIV in Indonesian patients显示文摘 | NungkiAnggorowati YoshihikoYano Didik SetyoHeriyanto Hanggoro TriRinonce TakakoUtsumi Deshinta PutriMulya Yanri WijayantiSubronto YoshitakeHayashi | 2012 | J. Med. Virol2012，，6： | 1 |
| 5 | Conversion of rice husk ash to zeolite beta显示文摘 | DIDIK P ZAINAB R SALASIAH E | 2006 | Waste Management2006，26，10： | 1 |
| 6 | Nonlinear Path-following Control of an AUV 显示文摘 | Lionel L Didik S | 2007 | Ocean Engineering2007，34，1112： | 1 |
| 7 | Nonlinear Path-following Control of an AUV 显示文摘 | Lionel L Didik S | 2007 | Ocean Engineering2007，，34： | 1 |
| 8 | Preparation and swelling of polymeric absorbent containing hydroxamic acid, group from polymer grafted sago starch 显示文摘 | Lutfor M R Didik S Wan Yunus W M Z | 2001 | Carbohy Polym2001，45，： | 1 |
| 9 | Nonlinear path-following control of an AUV显示文摘 | LIONEL L DIDIK S | 2007 | Ocean Engineering2007，34，1： | 1 |
| 10 | Nonlinear path-following control of an AUV 显示文摘 | LIONEL L DIDIK S | 2007 | Ocean Engineering2007，34，2： | 1 |
| 11 | Nonlinear path-following control of an AUV显示文摘 | Lionel Lapierre Didik Soetanto | 2007 | Ocean Engineering2007，34，2： | 1 |
| 12 | Staibiliza- tion of human standing posture using functional neuromuscu- lar stimulation显示文摘 | Didik Soetantoa Chen-Yuan Kuob Darko Babic | 2001 | Journal of Biomeehanics2001，34，12： | 1 |
| 13 | Reengineering for Human Resource Management in Japanese Companies: Is It Important to Be Introduced 显示文摘 | Didik P Kazuo T Masaharu O | 1999 | International Journal of Production Economics1999，，4： | 1 |
| 14 | Preparation and characterization of bifunctional oxidative and acidic catalysts Nb2O5/TS-1 for synthesis of diols显示文摘 | Didik Prasetyoko Zainab Ramli Salasiah Endud | 2005 | Materials Chemistry and Physics2005，93，： | 1 |
| 15 | Nonlinear path-following control of an AUV显示文摘 | Lionel Lapierre Didik Soetanto | 2007 | Ocean Engineering2007，34，11： | 1 |
| 16 | Preparation and swelling of polymeric absorbent containing hydroxamic acid group from polymer grafted sago starch显示文摘 | Lutfor M R Didik S Wan Yunus W M Z | 2001 | Carbohydrate Polymers2001，45，： | 1 |
| 17 | Morphology and Optical Properties of Self-Assembled In_(0.5)Ga_(0.5)As Quantum Dots with Different Spacer Layer Thickness显示文摘Introduction Self-assembled quantum dots (QDs) that are grown using epitaxial techniques have been extensively stud-ied due to their potential for various applications. Self-assembled InxGa1-xAs/GaAs QDs represent | Didik Aryanto Abd. Khamim Ismail Zulkafli Othaman | 2010 | Tsinghua Science and Technology2010，15，5： | 0 |
| 18 | Improvement of Physical and Biological Quality of Soil in a Sugarcane Plantation through the Management of Organic Matter Input显示文摘 | Nurhidayati Endang Arisoesilaningsih Didik Suprayogo Kumiatun Hairiah | 2015 | Journal of Agricultural Science and Technology(A)2015，5，5： | 0 |
| 19 | Human Wharton’s jelly mesenchymal stem cells inhibit cytokine storm in acute respiratory distress syndrome in a rat model显示文摘Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced rats.Methods:The hWJMSCs(5×10^(4)/mL,5×10^(5)/mL,5×10^(6)/mL)were administered to rats on day 1 and day 8 after being induced by LPS(5 mg/kg body weight).TNF-αlevels in the lung and IL-18 and IL-1βlevels in the serum were measured using ELISA.In addition,caspase-1 expression in lung tissues was quantified using qRT-PCR,and NF-κB and IL-6 expressions were assessed using immunohistochemistry.Results:The hWJMSCs decreased TNF-αlevels in the lung and plasma IL-18 and IL-1βlevels.Moreover,the hWJMSCs downregulated the expressions of caspase-1,IL-6,and NF-κB in lung tissues.Conclusions:The hWJMSCs can decrease inflammatory markers of acute respiratory distress syndrome in a rat model and may be further investigated for the treatment of acute respiratory distress syndrome. | Wahyu Widowati Teresa Liliana Wargasetia Fanny Rahardja Rimonta F Gunanegara Didik Priyandoko Marisca Evalina Gondokesumo Ervi Afifah Cahyaning Riski Wijayanti Rizal Rizal | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，8： | 0 |
| 20 | Cultural Influence,Organizational Climate,Ability of Information Technology to Motivation and Satisfaction Employees of Bankaltim显示文摘This research copes to study the relationship between cultural variables of organization,organizational climate,ability of information technology,motivation work to satisfaction of bank employees’performance and activity of BPD in East Kalimantan.This research addressed to analyze the cultural variable of organization,the ability of information technology,motivation and satisfaction.This research of the survey is done by using the approach of pad cross sectional study of 13 sub-provinces and town bank of BPD in East Kalimantan.Technique intake of the sample depends on random proportional sampling.Measurement is conducted with structural equation modeling(SEM)pass courses of AMOS 5 and 150 samples taken by bank employees of BPD in East Kalimantan.Result of examination with technique of SEM,indicated that the model has developed degree of axle.According to research data at moderating storey,result of evaluation of goodness of fit indices indicates result of the moderating to the overalls of constructs in the model.Partially developed constructs evaluate good fit of goodness.In general,all the exogenous variables(cultural of organization,the ability of information technology,and organizational climate)have significant effect on motivation and satisfaction of bank activity of BPD in East Kalimantan.Some hypotheses raised in this research can be accepted.Organizational culture has a significant effect on motivation work employees and satisfaction of activity,and ability of information technology has a significant effect on motivation and satisfaction of activity,while organizational climate does not. | Didik Hadiyatno | 2018 | Management Studies2018，6，4： | 0 |
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