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	题名	作者	年代	出处	被引量
1	RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone.	Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M	2013	中国神经肿瘤杂志2013，11，1：	8
2	Menstrual characteristics of women suffering from insulin-dependent diabetes mellitus显示文摘	Yeshaya A Orvieto R Dicker D	1995	Int J Fertil Menopausal Stud1995，40，5：	1
3	Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes显示文摘	van Harmelen V Dicker A Ryden M	2002	Diabetes2002，51，7：	1
4	Functional studies of mesenchymal stem cells derived from adult human adipose tissue 显示文摘	Dicker A Le Blanc K Astrom G	2005	Exp Cell Res2005，308，2：	1
5	Effects of a high- fat- sucrose diet on enzyme in homocysteine metabolism in the rat 显示文摘	Fonseca V Dicker - Brown A Ranganathan S	2000	Metabolism2000，49，6：	1
6	Relationship between varicocecle size and response to varicocelectomy 显示文摘	STECKEL J DICKER A P GOLDSTEIN M	1993	J Urol1993，149，4：	1
7	Green compo- sites: A review of material attributes and complementary applications 显示文摘	Dicker M P Duckworth P F Baker A B	2014	Composites Part A: Appl Sci Manuf2014，56，：	1
8	Functional characterization of human mesenchymal stem cell-derived adipocytes显示文摘	Ryden M Dicker A Gotherstrom C	2003	Biochem Biophys Res Commun2003，311，2：	1
9	Microsurgical inguinal varicocelectomy with delivery of the testis:an artery and lymphatic sparing technique显示文摘	Goldstein M Gilbert B R Dicker A P	1992	J Urol1992，148，6：	1
10	The global burden of cancer 2013显示文摘	Fitzmaurice C Dicker D Pain A	2015	JAMA Oncol2015，1，4：	1
11	The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase:studies in hepatocytes显示文摘	Fonseca VA Fink Lid	2001	Atheroseleresis2001，158，2：	1
12	Adipocyte lipases and de- fect of lipolysis in human obesity显示文摘	Langin D Dicker A Tavernier G	2005	Diabetes2005，54，11：	1
13	Adipocyte lipases and defect of lipolysis in human obesity 显示文摘	LANGIN D DICKER A TAVERNIER G	2005	Diabetes2005，54，11：	1
14	The global burden of cancer 2013显示文摘	Fitzmaurice C Dicker D Pain A	2015	JAMA oncology2015，1，4：	1
15	Adipocyte lipases and defect of lipolysis in human obesity显示文摘	LANGIN D DICKER A TAVERNIER G ET AL	2005	Diabetes2005，54，11：	1
16	Adipocyte lipases and defect of lipolysis in human obesity显示文摘	Langin D Dicker A Tavernier G	2005	Diabetes JT-Diabetes2005，54，11：	1
17	Effects of a high - fat - sucrose diet on enzymes in homocysteine metabolism in the rat 显示文摘	Fonseca V Dicker - Brown A Ranganathan S	2000	Metabolism2000，49，6：	1
18	Increased Hypoxia Correlates with Increased Expression of the Angiogenesis Marker Vascular Endothelial Growth Factor in Human Prostate Cancer显示文摘	CEVTKOVIC D MOVSAS B DICKER A P	2001	Urology2001，57，4：	1
19	Menstrual characteristics of women suffering from insulin-dependent diabetes mellitus 显示文摘	Yeshaya A Orvieto R Dicker D	1995	Int J Fertil Menopausal Study1995，40，5：	1
20	Efficacy and patterns of failure for locally advanced cancer of the cervix treated with celebrex (celecoxib)and chemoradiotherapy in RTOG 0128显示文摘	Gaffney D K Winter K Dicker A P	2007	Int J Radia Oneol Biol Phys2007，69，1：	1

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