|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Outcome of Patients with Colorectal Liver Metastasis: Analysis of 1,613 Consecutive Cases显示文摘 | Zhu Dexiang Ren Li Wei Ye Wu Haifu Zhong Yunshi Ye Qinghai Zhai Shenyong Xu Bo Liang Li Pan Xiangou Li Haohao Ye Lechi Liu Tianshu Fan Jia Qin Xinyu Xu Jianmin | 2012 | Annals of Surgical Oncology2012，，9： | 3 |
| 2 | Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine derivatives显示文摘A new series of 4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine derivatives have been designed and synthesized.The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 (human alveolar adenocarcinoma cell) and H460 (human lung cancer) by MTT assay.Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines.The most potent compound 4-(benzo[d][1,3]dioxol5-yl)-8,9-difluoro-2-(4-methylpiperazin-1-yl)-4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine (CH05) (IC50=0.44 M,3.07 M) was 2.0 and 8.4 times more active than gefitinib (IC50=0.89 M,16.81 M) against A549 and H460 cell lines,respectively. | GUO DeXiang LIU YaJing LI Ting WANG Nan ZHAI Xin HU Chun GONG Ping | 2012 | Science China Chemistry2012，55，3： | 2 |
| 3 | A study on the mutagenlclty of 102 raw pharmaceuticals used in Chinese traditional medicine显示文摘 | Yin Xuejun Liu Dexiang Wang Hechuan | 1991 | Mutation Res1991，260，： | 1 |
| 4 | Least squares finite element method with high continuity NURBS ba- sis for incompressible Navier-Stokes equations 显示文摘 | CHEN Dexiang XU Zili LIU Shi | 2014 | Journal of Computational Physics2014，260，： | 1 |
| 5 | Saturated fatty acids activate nficroglia via Toll - like receptor 4/ NF - kB signaling 显示文摘 | Wang Zhen Liu Dexiang Wang Fuwu | 2012 | British Journal of Nutrition2012，107，： | 1 |
| 6 | Responses of soil CH_(4) fluxes to nitrogen addition in two tropical montane rainforests in southern China显示文摘Background:Atmospheric nitrogen(N)deposition is projected to increase in the next few decades,which may have a marked impact on soil-atmosphere CH_(4) fluxes.However,the impacts of increased atmospheric N depositions on soil CH_(4) flux in tropical rainforests are still poorly understood.From January 2015 to December 2018,a field experiment was conducted in a primary tropical montane rainforest(PTMR)and a secondary tropical montane rainforest(STMR)in southern China to quantify the impact of N additions at four levels(N0:0 kg N⋅ha^(-1)⋅year^(-1);N25:25 kg N⋅ha^(-1)⋅year^(-1);N50:50 kg N⋅ha^(-1)⋅year^(-1);N100:100 kg N⋅ha^(-1)⋅year^(-1)on soil CH_(4) flux.Results:Four years of measurements showed clear seasonal variations in CH_(4) flux in all treatment plots for both forest types(PTMR and STMR),with lower rates of soil CH_(4) uptake during the wet season and higher rates of soil CH_(4) uptake during the dry season.Soil CH_(4) uptake rates were significantly and negatively correlated with both soil temperature and soil moisture for both forest types.Annual CH_(4) uptake for the N0 plots from the PTMR and STMR soils were2.20 and1.98 kg N⋅ha^(-1)⋅year^(-1),respectively.At the PTMR site,mean CH_(4) uptake compared with the N0 treatment was reduced by 19%,29%,and 36%for the N25,N50,and N100 treatments,respectively.At the STMR site,mean CH_(4) uptake compared with the N0 treatment was reduced by 15%,18%,and 38%for the N25,N50,and N100 treatments,respectively.High level N addition had a stronger inhibitory impact on soil CH_(4) uptake than did the low level N addition.Conclusion:Our data suggest that soil CH_(4) uptake in tropical rainforests is sensitive to N deposition.If atmospheric N deposition continues to increase in the future,the soil CH_(4) sink strength of tropical rainforests may weaken further. | Fangtao Wu Changhui Peng Chuanyao Wang Huai Chen Weiguo Liu Zhihao Liu Hui Wang Hong Li Dexiang Chen Yide Li Shirong Liu | 2022 | Forest Ecosystems2022，9，3： | 1 |
| 7 | Rodent-mediated plant community competition:what happens to the seeds after entering the adjacent stands?显示文摘Background:Seed dispersal by scatter-hoarding animals can affect the developmental dynamics of plant communities.However,how animals might participate in plant inter-community competition has rarely been investigated.Forest community junction is an area where the competition between plant communities is most prominent and animal activity is more frequent.At present,little is known about how scatter-hoarding animals might assist competitions by adjacent plant communities.Thus,for 3 years(2015–2017),we tracked the fate of 2880 tagged seeds(Quercus aliena var.acuteserrata,Pinus tabuliformis,and P.armandii seed)placed near an edge where the forest composition changes from a pine forest to an oak forest in northwestern China.Results:We found that the seed fates differed when Quercus and Pinus seeds entered adjacent stands.In contrast to Pinus seeds,acorns that entered pine forests were characterized by higher caching rates and longer dispersal distances.Pinus seeds had the highest probability of being predated(85%)by rodents,and eleven Q.aliena var.acuteserrata seedlings were established in pine forests,although none survived in the later stages.In addition,rodents exhibited obvious selectivity in terms of the microhabitats for the seed caching sites.Conclusions:Seed fates differed when Quercus and Pinus seeds entered adjacent stands.The predation pressure by rodents on the seeds of Pinus species limited the germination of seeds and seedling establishment in oak forests.The different seed fates after their bidirectional dispersal could affect the differences in natural regeneration between pine and oak forests,and they might increase the recruitment rates for oak at the edge of an adjacent community.Rodent-mediated seed dispersal could potential unintentionally affect the competition between plant communities. | Haibin Kang Mingjie Chang Shutong Liu Zhi Chao Xinping Zhang Dexiang Wang | 2020 | Forest Ecosystems2020，7，4： | 1 |
| 8 | Region-of-interest micro-focus computed tomography based on an all-optical inverse Compton scattering source显示文摘Micro-focus computed tomography(CT),which allows the hyperfine structure within objects to be reconstructed,is a powerful nondestructive testing tool in many fields.However,current x-ray sources for micro-focus CT are typically limited by their relatively low photon energy and low flux.An all-optical inverse Compton scattering source(AOCS)based on laser wakefield acceleration can generate intense quasi-monoenergetic x/gamma-ray pulses in the kilo-to megaelectronvolt range with micrometer-level source size,and its potential application for micro-focus CT has become very attractive in recent years because of the rapid progress made in laser wakefield acceleration.Reported here is a successful experimental demonstration of high-fidelity micro-focus CT using an AOCS(∼70 keV)by imaging and reconstructing a test object with complex inner structures.A region-of-interest CT method is adopted to utilize the relatively small field of view of the AOCS to ensure high spatial resolution.This demonstration of AOCS-based region-of-interest micro-focus CT is a key step toward its application in the field of hyperfine nondestructive testing. | Yue Ma Jianfei Hua Dexiang Liu Yunxiao He Tianliang Zhang Jiucheng Chen Fan Yang Xiaonan Ning Zhongshan Yang Jie Zhang Chih-Hao Pai Yuqiu Gu Wei Lu | 2020 | Matter and Radiation at Extremes2020，5，6： | 1 |
| 9 | Risk Management Model of a Micro-Grid Wind Farm显示文摘 | Jicheng Liu Suhua Wang Dexiang Wu CuiCui Luo Yajuan Yang | 2013 | Human and Ecological Risk Assessment: An International Journal2013，，5： | 1 |
| 10 | A study on the mutagenlchy of 102 raw pharmaceuticals used in Chinese traditional medicine 显示文摘 | Yin Xuejun Liu Dexiang Wang Hechuan | 1991 | Mutation Research1991，260，： | 1 |
| 11 | Cell-free DNA derived from cancer cells facilitates tumor malignancy through Toll-like receptor 9 signaling-triggered interleukin-8 secretion in colorectal cancer显示文摘 | Zhengchuan Niu Wentao Tang Tianyu Liu Pingping Xu Dexiang Zhu Meiling Ji Wenbai Huang Li Ren Ye Wei Jianmin Xu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 1 |
| 12 | Impact of climate warming on crop planting and production in Northwest China显示文摘 | Deng Zhenyong Zhang Qiang Pu Jinyong Liu Dexiang Guo Hui Wang Quanfu Zhao Hong Wang Heling | 2008 | Acta Ecologica Sinica2008，，8： | 1 |
| 13 | Tribological Mechanism of Graphene and Ionic Liquid Mixed Fluid on Grinding Interface under Nanofluid Minimum Quantity Lubrication显示文摘Graphene has superhigh thermal conductivity up to 5000 W/(m·K),extremely thin thickness,superhigh mechanical strength and nano-lamellar structure with low interlayer shear strength,making it possess great potential in mini-mum quantity lubrication(MQL)grinding.Meanwhile,ionic liquids(ILs)have higher thermal conductivity and better thermal stability than vegetable oils,which are frequently used as MQL grinding fluids.And ILs have extremely low vapor pressure,thereby avoiding film boiling in grinding.These excellent properties make ILs also have immense potential in MQL grinding.However,the grinding performance of graphene and ionic liquid mixed fluid under nano-fluid minimum quantity lubrication(NMQL),and its tribological mechanism on abrasive grain/workpiece grinding interface,are still unclear.This research firstly evaluates the grinding performance of graphene and ionic liquid mixed nanofluids(graphene/IL nanofluids)under NMQL experimentally.The evaluation shows that graphene/IL nanofluids can further strengthen both the cooling and lubricating performances compared with MQL grinding using ILs only.The specific grinding energy and grinding force ratio can be reduced by over 40%at grinding depth of 10μm.Work-piece machined surface roughness can be decreased by over 10%,and grinding temperature can be lowered over 50℃at grinding depth of 30μm.Aiming at the unclear tribological mechanism of graphene/IL nanofluids,molecular dynamics simulations for abrasive grain/workpiece grinding interface are performed to explore the formation mechanism of physical adsorption film.The simulations show that the grinding interface is in a boundary lubrication state.IL molecules absorb in groove-like fractures on grain wear flat face to form boundary lubrication film,and graphene nanosheets can enter into the grinding interface to further decrease the contact area between abrasive grain and workpiece.Compared with MQL grinding,the average tangential grinding force of graphene/IL nanofluids can decrease up to 10.8%.The interlayer shear effect and low interlayer shear strength of graphene nanosheets are the principal causes of enhanced lubricating performance on the grinding interface.EDS and XPS analyses are further carried out to explore the formation mechanism of chemical reaction film.The analyses show that IL base fluid happens chemical reactions with workpiece material,producing FeF_(2),CrF_(3),and BN.The fresh machined surface of workpiece is oxidized by air,producing NiO,Cr_(2)O_(3) and Fe_(2)O_(3).The chemical reaction film is constituted by fluorides,nitrides and oxides together.The combined action of physical adsorption film and chemical reaction film make graphene/IL nano-fluids obtain excellent grinding performance. | Dexiang Wang Yu Zhang Qiliang Zhao Jingliang Jiang Guoliang Liu Changhe Li | 2023 | Chinese Journal of Mechanical Engineering2023，36，4： | 0 |
| 14 | Study on Extraction of Zirconium,Niobium and Ruthenium with Di(1-methyl-heptyl)methyl Phosphonate from Nitric Acid显示文摘At present,most of the spacecrafts used for outer space exploration use(238)^Pu as heat source.The main production route was solvent extraction method using tributyl phosphate(TBP)as the extractant to separate and purify(238)^Pu from the irradiated neptunium target solution.However,there were some defects of TBP in the process of separation and purification of neptunium and plutonium.For example,high concentration HNO3 should be used for achieving high distribution ratio of Np in TBP,but that will cause severe acid hydrolysis to TBP.Therefore,it is necessary to choose an extractant with better extraction ability than TBP. | REN Bing TANG Hongbin JIANG Dexiang LIU Jinping HE Hui | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 15 | DIFFRACTION OF SOLITARY WATER WAVES AROUND THREE-DIMENSIONAL FLOATING BODIES显示文摘By using the matched asymptotic expansion method and the idea of edge layer, a mathematicmodel for describing the interaction between weakly nonlinear shallow-water waves and three-dimensional floatingbodies is formed in the paper. As a numerical example, the diffraction of a solitary wave around a vertically floating cir-cular cylinder has been investigated and the results are presented. The present method can further be extended to thestudy of wave diffraction around floating bodies of general shape. | Liu Yingzhong Zhu Dexiang Miao Guoping, Shanghai Jiao Tong Univ. | 1990 | Acta Mechanica Sinica1990，6，1： | 0 |
| 16 | Microbiome-metabolome analysis reveals cervical lesion alterations显示文摘Cervical cancer(CC)continues to be one of the most common cancers among females worldwide.It takes a few years or even decades for CC to arise in a minority of women with cervical precancers.An increasing corpus of studies today indicates that local microecology and carcinogenesis are intimately related.To investigate the changes in cericovaginal microecology with the development of cervical cancer,we performed 16S rDNA sequencing and metabolomic analysis in cericovaginal fluid from 10 LSIL patients,10 HSIL patients,10 CC patients and 10 healthy controls to reveal the differential flora and metabolites during cervical carcinogenesis.Carcinogenesis is associated with alterations in microbiome diversity,individual taxa,and functions with notable changes in Lactobacillus,Prevotella and Aquabacterium,as well as in cervicovaginal metabolites that correlate with cervicovaginal microbial patterns.Increased bacterial diversity and a decline in the relative abundance of Lactobacillus,the dominant species in the cericovaginal flora,are observed when cervical lesions advance.According to KEGG pathway enrichment analysis,lipids and organic acids change as cervical cancer progresses,and the phenylalanine,tyrosine,and tryptophan biosynthesis pathway is essential for the development of cervical cancer.Our results reveal that microbic and metabolomic profiling is capable of distinguishing CC from precancer and highlights potential biomarkers for the early detection of cervical dysplasia.These differential microorganisms and metabolites are expected to become a potential tool to assist in the diagnosis of cervical cancer. | Hanjie Xu Lou Liu Feng Xu Min Liu Yuexiao Song Jiale Chen Huiying Zhan Ye Zhang Dexiang Xu Yu Chen Mudan Lu Daozhen Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 17 | Liver dysfunction on admission worsens clinical manifestations and outcomes of coronavirus disease 2019显示文摘Background:Liver dysfunction was common in coronavirus disease 2019(COVID-19),but its association with clinical features and poor prognosis has not been fully delineated.Our study aimed to determine the role of liver dysfunction in COVID-19 and understand the predictors for worse outcomes in patients with liver injury.Methods:We conducted this multicenter,retrospective study in five designated hospitals for COVID-19 manage-ment.Laboratory-confirmed COVID-19 patients were enrolled and classified into the normal live function group and liver dysfunction group according to liver enzymes,bilirubin,and albumin on admission,respectively.Data of baseline,clinical manifestations,and outcomes were collected and compared in the paired groups.Results:Of the 649 included COVID-19 patients,200(30.8%),69(10.6%),and 267(41.1%)patients had elevated liver enzymes,increased bilirubin,and low-level albumin,respectively.Fever,cough,and dyspnea were the most common symptoms and showed an increased proportion in the liver dysfunction group.Compared with patients in the normal liver function group,patients with liver dysfunction manifested decreased lymphocytes,higher level of leukocytes,neutrophils,inflammatory indicators,and cytokines,as well as more severe impairment in kidney function and myocardium.They were more likely to show bilateral involvement and more pulmonary lobes involved according to chest images.With increased proportion of patients who developed severe/critical conditions and needed mechanical ventilation and systemic glucocorticoid therapy,patients with liver dysfunc-tion on admission showed significantly higher in-hospital mortality.Moreover,cardiac troponin I≥1.5 ng/mL was identified as an independent mortality predictor in the elevated liver enzymes group.Conclusion:Patients with liver dysfunction on admission had worse clinical manifestation,and resulted in higher rate of severe/critical type,receiving mechanical ventilation and in-hospital mortality. | Fangying Lu Rong Chen Kandi Xu Jie Huang Dexiang Yang Tao Bai Yusang Xie Yun Ling Kui Liu Wei Du Jiayang Yan Huihuang Lin Jian Li Yun Feng Min Zhou Yi Guo | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，3： | 0 |
| 18 | Study on fluid inclusions of Qiangsheng gold deposit in Fushun of Liaoning显示文摘The Qiangsheng gold deposit belongs to quartz vein type. The fluid inclusions consist of four types:aqueous single-phase inclusions,aqueous two-phase inclusions,carbonated two-phase inclusions and carbonated three-phase inclusions. The fluid inclusions are characterized by low salinity( 5%-9% Na Cl eqv),low density( 0. 66--0. 72 g / cm^3) and medium temperature( 210℃--250℃). The pressure of ore-forming is 60--95 MPa and the metallogenic depth is about 5. 49--7. 56 km. During the mineralizing process,ore-forming fluid underwent fluid unmixing in CO_2-H_2O-Na Cl system. The stable isotope results indicate that the ore-forming fluids mainly generated from mantle,with the participation of a small amount of atmospheric water. Comprehensive studies have suggested that Qiangsheng gold deposit belongs to the type of mesothermal hydrotherm with mantlederived fluid participating in mineralization. | CHEN Yang WANG Li ZHANG Yajing XU Chunliang JU Mingshen LIU Kuoliang LI Qiang SUN Dexiang ZHAO Chenghui | 2015 | Global Geology2015，18，4： | 0 |
| 19 | 热带森林优势种青冈叶片气孔、解剖和形态性状与气候、土壤因子的关联显示文摘了解优势树种叶片多水平的功能性状沿海拔梯度的变化及其内在关联,有助于预测优势种应对气候变化的响应与适应。本文研究了青冈属树种叶片气孔、解剖和形态性状沿海拔梯度的变化及其与环境调控因子的关联,探究了其生态策略是否随海拔发生改变。在海南尖峰岭热带森林,沿海拔梯度(400–1400 m)采集了6种常绿青冈:竹叶青冈(Cyclobalanopsis bambusaefolia)、雷公青冈(C.hui)、托盘青冈(C.patelliformis)、饭甄青冈(C.fleuryi)、吊罗山青冈(C.tiaoloshanica)和亮叶青冈(C.phanera)叶片,用于气孔、解剖和形态性状的测定。研究结果表明,随海拔升高,青冈树种叶片气孔密度、气孔孔隙度指数和叶面积显著增加,但海绵组织厚度比和干物质含量则显着降低。叶片气孔、解剖和形态性状沿海拔梯度的变化主要受年均温、年降水量和土壤pH值调控。在低海拔和高海拔处,青冈属采取“耐受”和“竞争”策略,而在中海拔处,则是“竞争”策略。土壤磷含量和土壤pH值随海拔的变化可能是驱动其生态策略转变的主要原因。该结果揭示,热带森林优势树种青冈可通过从气孔细胞-组织解剖结构-叶片水平功能性状的改变来响应环境变化。 | Yutong Lin Luhui Kuang Songbo Tang Zhijian Mou Oliver LPhillips Hans Lambers Zhanfeng Liu Jordi Sardans Josep Penelas Yuan Lai Mingxian Lin Dexiang Chen Yuanwen Kuang | 2021 | Journal of Plant Ecology2021，14，6： | 0 |
| 20 | The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury显示文摘We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation remains unclear.In this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal cortex.We also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ischemia.Furthermore,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these changes.These findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury. | Yijing Zhao Tong Li Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang | 2024 | Neural Regeneration Research2024，19，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员