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| 1 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 2 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 3 | Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double- blind, placebo-controlled pilot study显示文摘 | Devlin J W A1-Qadheeb N S Chi A | 2014 | Chest2014，145，6： | 1 |
| 4 | Is there a case for using visual analogue scale valuations in cost-utility analysis? 显示文摘 | Parkin D Devlin N | 2006 | Health Econ2006，15，7： | 1 |
| 5 | Aftermath of surgery for anorectal cancer显示文摘 | Devlin HB Plant JA Griffin N | 1971 | Br Med J1971，3，5： | 1 |
| 6 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 7 | Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure: a randomized, double- blind, placebo-controlled pilot study显示文摘 | Devlin J W AI-Qadheeb N S Chi A | 2014 | Chest2014，145，6： | 1 |
| 8 | Evidence for an inverse relationship between the differentiation of adipocytic andosteogenic cells in rat marrow stromal cell cultures显示文摘 | Beresford J N Bennett J H Devlin C | 1992 | J Cell Sci1992，102，2： | 1 |
| 9 | Assessment of potential donors for living related liver transplantation显示文摘 | BAKER A Dhawan A Devlin J Mieli-Vergani G. O Grady J. Williams R Rela M. Heaton N | | 0，，： | 1 |
| 10 | STAT 3 phosphorylation in injured axons before sensory and motor neuron nuclei:potential role for STAT 3 as a retrograde signaling transcription factor显示文摘 | LEE N NEITZEL K L DEVLIN B K | 2004 | J Comp Neurol2004，474，4： | 1 |
| 11 | Vagifemvs Premarin vaginal creama-comparative evaluation 显示文摘 | Devlin C Gelfan MM Nanavati N | 1997 | Maturitas1997，27，1： | 1 |
| 12 | Continuity through change:the rhetoric and reality of health reform in New Zealand显示文摘 | Ashton T Mays N Devlin N | 2005 | Social Science & Medicine2005，61，2： | 1 |
| 13 | Fractional paternity assign-ment,theoretical development and comparision to other methods显示文摘 | DEVLIN B ROEDER K ELLSTRAND N C | 1988 | The-oretical and Applied Genetics1988，76，： | 1 |
| 14 | The development and application of a re-fined method for estimating gene flow from angiosperm paternity analysis显示文摘 | DEVLIN B ELLSTRAND N C | 1990 | Evolution1990，44，2： | 1 |
| 15 | Mutation of the 9q34 gene TSC1 in sporadic bladder cancer显示文摘 | Devlin J Davies AM | 1999 | Oncogene1999，18，16： | 1 |
| 16 | Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic ceils in rat marrow stromal cell cultures 显示文摘 | BERESFORD J N BENNETT J H DEVLIN C | 1992 | J Cell Sci1992，102，3： | 1 |
| 17 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE3rd Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A McLean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 18 | Searching for cost effec-tiveness thresholds in the NHS显示文摘 | Appleby J Devlin N Parkin D | 2009 | Health Policy2009，91，3： | 1 |
| 19 | Does NICE have a cost-effctiveness thre-shold and what other factors influence its decisions?A binary choice analysis显示文摘 | Devlin N Parkin D | 2004 | Health Economics2004，13，5： | 1 |
| 20 | New Zealand's new health sector reforms: Back to the Future显示文摘 | Devlin N Maynard A Mays | 2005 | BMJ2005，，322： | 1 |
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