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| 1 | Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells显示文摘Pancreatic cancer(PC) is the most aggressive type of common cancers, and in 2014, nearly 40000 patients died from the disease in the United States. Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is characterized by an intense stromal desmoplastic reaction surrounding the cancer cells. Cancer-associated fibroblasts(CAFs) are the main effector cells in the desmoplastic reaction, and pancreatic stellate cells are the most important source of CAFs. However, other important components of the PC stroma are inflammatory cells and endothelial cells. The aim of this review is to describe the complex interplay between PC cells and the cellular and noncellular components of the tumour stroma. Published data have indicated that the desmoplastic stroma protects PC cells against chemotherapy and radiation therapy and that it might promote the proliferation and migration of PC cells. However, in animal studies, experimental depletion of the desmoplastic stroma and CAFs has led to more aggressive cancers. Hence, the precise role of the tumour stroma in PC remains to be elucidated. However, it is likely that a contextdependent therapeutic modification, rather than pure depletion, of the PC stroma holds potential for the development of new treatment strategies for PC patients. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2016 | World Journal of Gastroenterology2016，22，9： | 20 |
| 2 | Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations显示文摘AIM To determine whether it is possible to identify different immune phenotypic subpopulations of cancer-associated fibroblasts (CAFs) in pancreatic cancer (PC). METHODS We defined four different stromal compartments in surgical specimens with PC: The juxtatumoural, peripheral, lobular and septal stroma. Tissue microarrays were produced containing all pre-defined PC compartments, and the expression of 37 fibroblast (FB) and 8 extracellular matrix (ECM) markers was evaluated by immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization. The compartment-specific mean labelling score was determined for each marker using a four-tiered scoring system. DOG1 gene expression was examined byquantitative reverse transcription PCR (qPCR). RESULTS CD10, CD271, cytoglobin, DOG1, miR-21, nestin, and tenascin C exhibited significant differences in expression profiles between the juxtatumoural and peripheral compartments. The expression of CD10, cytoglobin, DOG1, nestin, and miR-21 was moderate/strong in juxtatumoural CAFs (j-CAFs) and barely perceptible/weak in peripheral CAFs (p-CAFs). The upregulation of DOG1 gene expression in PC compared to normal pancreas was verified by qPCR. Tenascin C expression was strong in the juxtatumoural ECM and barely perceptible/weak in the peripheral ECM. CD271 expression was barely perceptible in j-CAFs but moderate in the other compartments. Galectin-1 was stronger expressed in j-CAFs vs septal fibroblasts, PDGFRβ, tissue transglutaminase 2, and hyaluronic acid were stronger expressed in lobular fibroblasts vs p-CAFs, and plectin-1 was stronger expressed in j-CAFs vs l-FBs. The expression of the remaining 33 markers did not differ significantly when related to the quantity of CAFs/FBs or the amount of ECM in the respective compartments.CONCLUSION Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. Future studies should determine whether CAF subpopulations have different functional properties. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 3 | The education of informationists,from the perspective of a library and information sciences educator显示文摘 | Ellen G Detlefsen D L S | 2002 | Journal of medical library association2002，90，1： | 1 |
| 4 | High-resolution solution structure of siamycin Ⅱ:novel amphipathic character of a 21-residue peptide that inhibits HIV fusion 显示文摘 | Friedrichs MS Detlefsen D | 1995 | J Biomol NMR1995，5，3： | 1 |
| 5 | Fibrosis of the pancreas: the initial tissue damage and the resulting pattern显示文摘 | Günter Kl?ppel S?nke Detlefsen Bernd Feyerabend | 2004 | Virchows Archiv2004，，1： | 1 |
| 6 | Fibrosis of the pancreas: the initial tissue damage and the resulting pattern 显示文摘 | Klppel G Detlefsen S Feyerabend B | 2004 | Virchows Arch2004，445，1： | 1 |
| 7 | A multifonctional neural electrode stimulation ASIC using NeuroTalk interface显示文摘 | Troyk PR Detlefsen DA DeMichele GD | 2006 | Cord Proc IEEE Eng Med Biol Soc2006，1，29： | 1 |
| 8 | Autoimmune pancreatitis 显示文摘 | Detlefsen S Drewes A M | 2009 | Scand J Gastroenterol2009，44，12： | 1 |
| 9 | Pain in chronic pancreatitis: the role of neuropathic pain mechanisms 显示文摘 | Drewes AM Krarup AL Detlefsen S | 2008 | Gut2008，57，11： | 1 |
| 10 | Investigation of variables affecting hot-press formaldehyde and methanol emissions during laboratory production of ureaformaldehyde-bonded particleboard显示文摘 | Wolcott Jeffrey J Motter William K Daisy Nicholas K Tenhaeff Steven C Detlefsen William D | 1996 | Forest Products Journal1996，46，： | 1 |
| 11 | Clinical features and relapse rates after surgery in type 1 autoimmune pancreatitis differ from type 2: A study of 114 surgically treated European patients显示文摘 | S?nke Detlefsen Giuseppe Zamboni Luca Frulloni Bernd Feyerabend Felix Braun Oke Gerke Anna Melissa Schlitter Irene Esposito Günter Kl?ppel | 2012 | Pancreatology2012，，3： | 1 |
| 12 | Condition and dynamic convex risk measures显示文摘 | Detlefsen K Scandolo G | 2005 | Finance and Stochastics2005，9，4： | 1 |
| 13 | The education of informationists,from the perspective of a library and information sciences educator显示文摘 | Ellen G Detlefsen D L S | 2002 | Journal of Medical Library Association2002，90，1： | 1 |
| 14 | Fibrosis of the pancreas; the initial tissue damage and the resulting pattern 显示文摘 | Kloppel G Detlefsen S Feyerabend B | 2004 | Virchows Arch2004，445，： | 1 |
| 15 | Fibrosis of the pancreas: the initial tissue damage and the resulting pattern显示文摘 | Günter Kl?ppel S?nke Detlefsen Bernd Feyerabend | 2004 | Virchows Archiv2004，，1： | 1 |
| 16 | Autoimmune pancreatitis:the clinicopathological characteristics of the subtype with granulocytic epithelial lesions显示文摘 | Kl(o)ppel G Detlefsen S Chari ST | 2010 | J Gastroenterol2010，45，： | 1 |
| 17 | Autoimmune pancreatitis: the clinicopathological characteristics of the subtype with granulocytic epithelial lesions 显示文摘 | K|ppel G Detlefsen S Chari ST | 2010 | J Gastroenterol2010，45，8： | 1 |
| 18 | Autoimmune panereafitis显示文摘 | Detlefsen S Drewes AM | 2009 | Scand J Gastroenterol2009，44，： | 1 |
| 19 | Autoimmune pancreatitis显示文摘 | Detlefsen S Drewes AM | 2009 | Scand J Gastroenterol2009，44，12： | 1 |
| 20 | Fibrogenesis in alcoholic chronic panereatitis:the role of tissue necrosis,macrosis,macrophages,myofibrob iasts and cytokines显示文摘 | Detlefsen S Sipos B Feyerabend B et al | 2006 | Med Pathol2006，19，8： | 1 |
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